論文

査読有り
2019年1月8日

Long-term management and postmortem examination in a diabetic cat with acromegaly treated with two courses of radiation therapy.

The Journal of veterinary medical science
  • Harumi Sawada
  • ,
  • Akihiro Mori
  • ,
  • Masaki Michishita
  • ,
  • Hitomi Oda
  • ,
  • Toshinori Sako

81
1
開始ページ
71
終了ページ
76
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.17-0289

A 12-year-old, castrated male cat with diabetes mellitus was diagnosed with acromegaly and examined with magnetic resonance imaging (enlarged pituitary gland, 8 mm); serum hormone concentrations were measured. After the first course of radiation therapy (4 Gy, 12 fractions), insulin administration was not required from day 420 after diagnosis. Enlarged pituitary tumor (8 mm) recurred, and insulin dosage amount of the cat was increased on day 1,065. The second course of radiation therapy (6 Gy, 4 fractions) was performed on day 1,201 and insulin administration was again discontinued. However, the cat died from lymphoma on day 1,397. Postmortem examination revealed pituitary adenoma. Most tumor cells were positive for chromogranin A, synaptophysin, and growth hormone immunohistochemistry. The pancreatic islet cells revealed diffuse hyperplasia. We achieved long-term successful management of an acromegalic cat with two courses of RT. However, a protocol for a second course of RT for feline recurrent pituitary tumor should be further discussed.

リンク情報
DOI
https://doi.org/10.1292/jvms.17-0289
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30449819
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361652
ID情報
  • DOI : 10.1292/jvms.17-0289
  • ISSN : 0916-7250
  • PubMed ID : 30449819
  • PubMed Central 記事ID : PMC6361652

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