2016年9月
Crystal structure of a [NiFe] hydrogenase maturation protease HybD from Thermococcus kodakarensis KOD1
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
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- 巻
- 84
- 号
- 9
- 開始ページ
- 1321
- 終了ページ
- 1327
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/prot.25070
- 出版者・発行元
- WILEY-BLACKWELL
A [NiFe] hydrogenase maturation protease HybD from Thermococcus kodakarensis KOD1 (TkHybD) is involved in the cleavage of the C-terminal residues of [NiFe] hydrogenase large subunits by Ni recognition. Here, we report the crystal structure of TkHybD at 1.82 angstrom resolution to better understand this process. TkHybD exhibits an // sandwich fold with conserved residues responsible for the Ni recognition. Comparisons of TkHybD with homologous proteins also reveal that they share a common overall architecture, suggesting that they have similar catalytic functions. Our results including metal binding site prediction provide insight into the substrate recognition and catalysis mechanism of TkHybD. Proteins 2016; 84:1321-1327. (c) 2016 Wiley Periodicals, Inc.
- リンク情報
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- DOI
- https://doi.org/10.1002/prot.25070
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27192667
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382812900013&DestApp=WOS_CPL
- URL
- http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=DRCI_CEL&KeyUT=DRCI:DATA2016189009730498&KeyUID=DRCI:DATA2016189009730498
- URL
- http://orcid.org/0000-0003-3537-2114
- ID情報
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- DOI : 10.1002/prot.25070
- ISSN : 0887-3585
- eISSN : 1097-0134
- ORCIDのPut Code : 37333881
- PubMed ID : 27192667
- Web of Science ID : WOS:000382812900013