田中明人 (Akito Tanaka) - マイポータル

基本情報

所属: 兵庫医科大学薬学部教授

研究者番号: 30454789
J-GLOBAL ID: 202401013265031129
researchmap会員ID: R000072977

研究キーワード

huhs015

研究分野

論文

Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug.

Tadashi Shimizu, Keiko Yamaguchi, Momoka Yamamoto, Rina Kurioka, Yukari Kino, Wataru Matsunaga, Syuhei Nakao, Hiroshi Fukuhara, Akito Tanaka, Akinobu Gotoh …

Bioorganic & medicinal chemistry letters 30(1) 126744-126744 2020年1月1日
Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo.

Masahiro Ueda, Tadashi Shimizu, Miyuki Mabuchi, Kota Horiike, Kaori Kitae, Hiroaki Hase, Yuko Ueda, Kazutake Tsujikawa, Akito Tanaka

Anticancer research 38(1) 211-218 2018年1月
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.

Syuhei Nakao, Miyuki Mabuchi, Shenglan Wang, Yoko Kogure, Tadashi Shimizu, Koichi Noguchi, Akito Tanaka, Yi Dai

Bioorganic & medicinal chemistry letters 27(14) 3167-3172 2017年7月15日
Selective degradation of splicing factor CAPERα by anticancer sulfonamides.

Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi, Kaoru Ogawa Mitsuhashi, Noboru Yamamoto, Hiroshi Kamiyama, Kentaro Takahashi, Yoshihiko Kotake, Mai Uesugi …

Nature chemical biology 13(6) 675-680 2017年6月
Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model.

Miyuki Mabuchi, Masahiro Ueda, Yuri Yoshida, Kota Horiike, Kenta Yamaoka, Syuhei Nakao, Tadashi Shimizu, Yuko Ueda, Kazutake Tsujikawa, Akito Tanaka

Anticancer research 37(4) 1665-1676 2017年4月
Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.

Takeshi Kanno, Ayako Tsuchiya, Akito Tanaka, Tomoyuki Nishizaki

Molecular neurobiology 53(7) 4787-97 2016年9月
The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling.

Tomoyuki Nishizaki, Akinobu Gotoh, Tadashi Shimizu, Akito Tanaka

Scientific reports 6 27267-27267 2016年6月2日
HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.

Yoshiko Kaku, Ayako Tsuchiya, Tadashi Shimizu, Akito Tanaka, Tomoyuki Nishizaki

Anticancer research 36(1) 39-48 2016年1月
Phosphatidylinositol Derivatives Induce Gastric Cancer Cell Apoptosis by Accumulating AIF and AMID in the Nucleus.

Masato Ohyama, Ayako Tsuchiya, Yoshiko Kaku, Takeshi Kanno, Tadashi Shimizu, Akito Tanaka, Tomoyuki Nishizaki

Anticancer research 35(12) 6563-71 2015年12月
Identification and purification of target protein using affinity resin bearing a photo-labile linker.

Miyuki Mabuchi, Tadashi Shimizu, Masayuki Haramura, Akito Tanaka

Bioorganic & medicinal chemistry letters 25(16) 3373-7 2015年8月15日
Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506.

Miyuki Mabuchi, Tadashi Shimizu, Masahiro Ueda, Kuniko Mitamura, Shigeo Ikegawa, Akito Tanaka

Bioorganic & medicinal chemistry letters 25(14) 2788-92 2015年7月15日
Linoleic acid derivative DCP-LA ameliorates stress-induced depression-related behavior by promoting cell surface 5-HT1A receptor translocation, stimulating serotonin release, and inactivating GSK-3β.

Takeshi Kanno, Akito Tanaka, Tomoyuki Nishizaki

Molecular neurobiology 51(2) 523-32 2015年4月
The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.

Yoshiko Kaku, Ayako Tsuchiya, Takeshi Kanno, Shuhei Nakao, Tadashi Shimizu, Akito Tanaka, Tomoyuki Nishizaki

Cancer chemotherapy and pharmacology 75(3) 527-35 2015年3月
Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.

Miyuki Mabuchi, Tadashi Shimizu, Masahiro Ueda, Yuka Sasakawa, Syuhei Nakao, Yuko Ueda, Akio Kawamura, Kazutake Tsujikawa, Akito Tanaka

In vivo (Athens, Greece) 29(1) 39-43 2015年
DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain.

Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Miyuki Mabuchi, Akito Tanaka, Tomoyuki Nishizaki

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 37(1) 193-200 2015年
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1- yloxy)propan-2-ol may be a promising anticancer drug.

Tomoyuki Nishizaki, Takeshi Kanno, Ayako Tsuchiya, Yoshiko Kaku, Tadashi Shimizu, Akito Tanaka

Molecules (Basel, Switzerland) 19(12) 21462-72 2014年12月19日
Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma.

Yoshiko Kaku, Hisao Nagaya, Ayako Tsuchiya, Takeshi Kanno, Akinobu Gotoh, Akito Tanaka, Tadashi Shimizu, Syuhei Nakao, Chiharu Tabata, Takashi Nakano …

Cancer science 105(7) 883-9 2014年7月
A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity.

Ayako Tsuchiya, Takeshi Kanno, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Chiharu Tabata, Takashi Nakano, Tomoyuki Nishizaki

Cancer letters 347(1) 123-8 2014年5月28日
Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs.

Syuhei Nakao, Miyuki Mabuchi, Tadashi Shimizu, Yoshihiro Itoh, Yuko Takeuchi, Masahiro Ueda, Hiroaki Mizuno, Naoko Shigi, Ikumi Ohshio, Kentaro Jinguji …

Bioorganic & medicinal chemistry letters 24(4) 1071-4 2014年2月15日
DCP-LA-phosphatidylinositol and its enantiomer exhibit different bioactivities.

Ayako Tsuchiya, Takeshi Kanno, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 33(2) 300-9 2014年

もっとみる

共同研究・競争的資金等の研究課題

ＰＣＡ－１阻害薬の臨床応用に向けた創薬研究

日本学術振興会科学研究費助成事業基盤研究(C) 2015年4月 - 2018年3月

所美雪, 辻川和丈, 田中明人
ホルモン非依存的前立腺がんにも有効な新規PCA-1阻害剤の探索合成

日本学術振興会科学研究費助成事業基盤研究(C) 2014年4月 - 2017年3月

田中明人, 辻川和丈, 所美雪, 井上豪