2009年6月
Reversible signal regulation system of F-19 NMR by redox reactions using a metal complex as a switching module
BIOORGANIC & MEDICINAL CHEMISTRY
- ,
- ,
- ,
- 巻
- 17
- 号
- 11
- 開始ページ
- 3818
- 終了ページ
- 3823
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmc.2009.04.039
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We present here the reversible signal regulation of F-19 NMR using the transition metal complex as a switching module. Water-soluble fluorinated dendrimers containing ferrocene were synthesized as a probe, and the signal intensities of F-19 NMR of the probes were monitored by changing the valence state of the ferrocene moiety. By oxidation of the ferrocene moiety, the relaxation of the nearby fluorine atoms was accelerated via the paramagnetic relaxation enhancement, as a result the 19F NMR signal from the probe was significantly decreased. The reduction of the ferrocenium cation of the probe recovered the signal intensity. Finally, in combination with the difference of the fluorescence quenching ability between ferrocene and ferrocenium cation, we constructed the multimodal F-19 NMR/fluorescence probe based on the redox switching system. (C) 2009 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmc.2009.04.039
- ISSN : 0968-0896
- eISSN : 1464-3391
- Web of Science ID : WOS:000266117400010