2016年3月
Claudin-21 Has a Paracellular Channel Role at Tight Junctions
MOLECULAR AND CELLULAR BIOLOGY
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- 巻
- 36
- 号
- 6
- 開始ページ
- 954
- 終了ページ
- 964
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/MCB.00758-15
- 出版者・発行元
- AMER SOC MICROBIOLOGY
Claudin protein family members, of which there are at least 27 in humans and mice, polymerize to form tight junctions (TJs) between epithelial cells, in a tissue-and developmental stage-specific manner. Claudins have a paracellular barrier function. In addition, certain claudins function as paracellular channels for small ions and/or solutes by forming selective pores at the TJs, although the specific claudins involved and their functional mechanisms are still in question. Here we show for the first time that claudin-21, which is more highly expressed in the embryonic than the postnatal stages, acts as a paracellular channel for small cations, such as Na+, similar to the typical channel-type claudins claudin-2 and -15. Claudin-21 also allows the paracellular passage of larger solutes. Our findings suggest that claudin-21-based TJs allow the passage of small and larger solutes by both paracellular channel-based and some additional mechanisms.
- リンク情報
- ID情報
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- DOI : 10.1128/MCB.00758-15
- ISSN : 0270-7306
- eISSN : 1098-5549
- PubMed ID : 26729464
- Web of Science ID : WOS:000372330700009