論文

査読有り 国際誌
2020年4月29日

Empagliflozin attenuates acute kidney injury after myocardial infarction in diabetic rats.

Scientific reports
  • Atsushi Kuno
  • Yukishige Kimura
  • Masashi Mizuno
  • Hiroto Oshima
  • Tatsuya Sato
  • Norihito Moniwa
  • Marenao Tanaka
  • Toshiyuki Yano
  • Masaya Tanno
  • Takayuki Miki
  • Tetsuji Miura
  • 全て表示

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1
開始ページ
7238
終了ページ
7238
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-64380-y

Acute kidney injury (AKI) predicts poor prognosis in patients with acute myocardial infarction (MI) and diabetes mellitus (DM) is an independent risk factor of AKI. Recent clinical studies have shown the beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cardiovascular and renal outcomes in patients with DM. We recently reported that canagliflozin normalized susceptibility of diabetic rats to AKI after acute MI via β-hydroxybutyrate-mediated suppression of NOX expression. Here we examined whether the same renoprotective effect is shared by empagliflozin. Serum creatinine levels were not changed by MI induced by coronary artery occlusion in LETO, non-diabetic control rats, and OLETF, obese type 2 diabetic rats. However, immunohistochemistry revealed that MI increased renal expression of NGAL and KIM-1, early markers of tubular injury, by 3.2-fold and 2.6-fold, respectively, in OLETF. These increases in injury markers were not observed in LETO. Pretreatment with empagliflozin of OLETF for 2 weeks improved hyperglycemia, increased blood β-hydroxybutyrate level, and suppressed MI-induced expression of NGAL and KIM-1. Empagliflozin suppressed upregulation of NOX2 and NOX4 in the kidney of OLETF. Taken together with the results of our previous study, it was concluded that treatment with the SGLT2 inhibitor protects the diabetic kidney from MI-induced AKI.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-64380-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32350374
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190820
ID情報
  • DOI : 10.1038/s41598-020-64380-y
  • PubMed ID : 32350374
  • PubMed Central 記事ID : PMC7190820

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