2017年9月12日
Synthetic Analogues of Nitrogenase Metallocofactors: Challenges and Developments.
Chemistry (Weinheim an der Bergstrasse, Germany)
- ,
- ,
- ,
- 巻
- 23
- 号
- 51
- 開始ページ
- 12425
- 終了ページ
- 12432
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.201702496
Nitrogenase is the only known biological system capable of reducing N2 to NH3 , which is a critical component of bioavailable nitrogen fixation. Since the discovery of discrete iron-sulfur metalloclusters within the nitrogenase MoFe protein, synthetic inorganic chemists have sought to reproduce the structural features of these clusters in order to understand how they facilitate the binding, activation and hydrogenation of N2 . Through the decades following the initial identification of these clusters, significant progress has been made to synthetically replicate certain compositional and functional aspects of the biogenic clusters. Although much work remains to generate synthetic iron-sulfur clusters that can reduce N2 to NH3 , the insights borne from past and recent developments are discussed in this concept article.
- ID情報
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- DOI : 10.1002/chem.201702496
- PubMed ID : 28726330