TAKAHIRO NII - My portal

Profile Information

Affiliation: Assistant Professor, Faculty of Applied Biological Science, Hiroshima University

Researcher number: 90804873
J-GLOBAL ID: 202101013249849950
researchmap Member ID: R000031670

I work on the research about enhancement of mucosal barrier function and improvement of egg production for health and secure poultry production of chickens. In particular, I focus on the intestinal environment and the network between intestine and surrounding organs such asliver, brain and reproductive organs.

Research Interests

Research History

Apr, 2017 - Mar, 2019

Assistant Professor, Academy of Agricultural Science Unit, Graduate School of Biosphere Science, Hiroshima University
Apr, 2015 - Mar, 2017

Researcher, R&D Center, Nippon-ham Foods Ltd.
Apr, 2013 - Mar, 2015

Research Fellow of the Japan Society for the Promotion of Science (DC2), Gradate School of Biosphere Science, Hiroshima University

Education

Apr, 2012 - Mar, 2015

Department of Bioresource Science, Ph.D. Agriculture, Graduate School of Biosphere Science, Hiroshima University
Apr, 2010 - Mar, 2012

Department of Bioresource Science, M.Sc. Agriculture, Graduate School of Biosphere Science, Hiroshima University
Apr, 2006 - Mar, 2010

B.Sc. Agriculture, Faculty of Applied Life Science, Nippon Veterinary and Life Science University

Committee Memberships

Apr, 2021 - Present

Chairman, Japanese Society of Animal Science, Young Researcher Committee
Apr, 2020 - Present

Chairman, Japan Poultry Science Association, Young Rsearchers Committee
May, 2020

Reviewer Board, Biology — Open Access Journal
Apr, 2020

Editorial Board, Japan Poultry Science Association

Awards

Papers

Effects of Newcastle disease and infectious bronchitis vaccine and yeast products feeding on the innate immune system in the proventriculus and ileum of broiler chicks.

Yoshimura Y, Nii T, Isobe N

Journal of Poultry Science, 60, Jan 5, 2023 Peer-reviewed
Effect of temporary cessation of milking and estradiol combination on the antimicrobial components in goat milk

Fika Yuliza Purba, Yoshihisa Ishimoto, Takahiro Nii, Naoki Suzuki, Naoki Isobe

Research in Veterinary Science, 152 387-394, Dec, 2022
Effect of repeated intrauterine infusion of lipopolysaccharides on mastitis in goats

Jirapat Jaisue, Takahiro Nii, Naoki Suzuki, Yusaku Tsugami, Naoki Isobe

Theriogenology, Sep, 2022
Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs

Yusaku Tsugami, Sayaka Nakayama, Naoki Suzuki, Takahiro Nii, Naoki Isobe

Frontiers in Immunology, 13, Aug 10, 2022
Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats

Yusaku Tsugami, Naoki Suzuki, Takahiro Nii, Naoki Isobe

Journal of Mammary Gland Biology and Neoplasia, Jun 9, 2022 Peer-reviewed
Modulation of the innate immune system by lipopolysaccharide in the proventriculus of chicks inoculated with or without Newcastle disease and infectious bronchitis vaccine.

Yoshimura Y, Kondo H, Takamatsu K, Tsugami Y, Nii T, Isobe N

Poultry Science, 2022 Peer-reviewed
Relationship between mucosal barrier function of the oviduct and intestine and egg productive system of laying hens.

Takahiro Nii

The Journal of Poultry Science, 2022 Peer-reviewed
Local Heat Treatment of Goat Udders Influences Innate Immune Functions in Mammary Glands

Tsugami, Yusaku, Ishiba, Yuki, Suzuki, Naoki, Nii, Takahiro, Kobayashi, Ken, Isobe, Naoki

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 26(4) 387-397, Dec, 2021 Peer-reviewed
Slight Disruption in Intestinal Environment by Dextran Sodium Sulfate Reduces Egg Yolk Size Through Disfunction of Ovarian Follicle Growth

Nii, Takahiro, Bungo, Takashi, Isobe, Naoki, Yoshimura, Yukinori

FRONTIERS IN PHYSIOLOGY, 11, Jan 15, 2021 Peer-reviewed
Effect of temporary cessation of milking on the innate immune components in goat milk.

Purba FY, Ishimoto Y, Nii T, Yoshimura Y Isobe N

Journal of Dairy Science, 104(9) 10374-10381, 2021 Peer-reviewed
Effects of avian infectious bronchitis with Newcastle disease and Marek's disease vaccinations on the expression of toll-like receptors and avian beta-defensins in the kidneys of broiler chicks

Shimizu, Masahiro, Nii, Takahiro, Isobe, Naoki, Yoshimura, Yukinori

POULTRY SCIENCE, 99(12) 7092-7100, Dec, 2020 Peer-reviewed
Effects of Probiotics Lactobacillus reuteri and Clostridium butyricum on the Expression of Toll-like Receptors, Pro- and Anti-inflammatory Cytokines, and Antimicrobial Peptides in Broiler Chick Intestine

Terada, Takumi, Nii, Takahiro, Isobe, Naoki, Yoshimura, Yukinori

JOURNAL OF POULTRY SCIENCE, 57(4) 310-318, Oct, 2020 Peer-reviewed
Effects of Toll-like Receptor Ligands on the Expression of Proinflammatory Cytokines and Avian beta-defensins in Cultured Chick Intestine

Terada, Takumi, Nii, Takahiro, Isobe, Naoki, Yoshimura, Yukinori

JOURNAL OF POULTRY SCIENCE, 57(3) 210-222, Jul, 2020 Peer-reviewed
Effect of antibiotic treatment on microbial composition and expression of antimicrobial peptides and cytokines in the chick cecum

Terada, T., Nii, T., Isobe, N., Yoshimura, Y.

POULTRY SCIENCE, 99(7) 3385-3392, Jul, 2020 Peer-reviewed
Lactobacillus reuteri Enhances the Mucosal Barrier Function against Heat-killed Salmonella Typhimurium in the Intestine of Broiler Chicks

Nii, Takahiro, Kakuya, Haruna, Isobe, Naoki, Yoshimura, Yukinori

JOURNAL OF POULTRY SCIENCE, 57(2) 148-159, Apr, 2020 Peer-reviewed
Intestinal inflammation induced by dextran sodium sulphate causes liver inflammation and lipid metabolism disfunction in laying hens

Nii, T., Bungo, T., Isobe, N., Yoshimura, Y.

POULTRY SCIENCE, 99(3) 1663-1677, Mar, 2020 Peer-reviewed
Translocation of intrauterine-infused bacterial lipopolysaccharides to the mammary gland in dexamethasone-treated goats.

Purba FY, Nii T, Yoshimura Y, Isobe N

Reproduction in Domestic Animals, 55(12) 1688-1697, 2020 Peer-reviewed
Effects of oral administration of colostrum whey in peripartum goat on antimicrobial peptides in postpartum milk

Isobe, Naoki, Matsukawa, Shoko, Kubo, Kota, Ueno, Kazutoshi, Sugino, Toshihisa, Nii, Takahiro, Yoshimura, Yukinori

ANIMAL SCIENCE JOURNAL, 91(1), 2020 Peer-reviewed
Effects of intrauterine infusion of bacterial lipopolysaccharides on the mammary gland inflammatory response in goats

Purba, Fika Yuliza, Ueda, Jo, Nii, Takahiro, Yoshimura, Yukinori, Isobe, Naoki

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 219 109972-109972, Jan, 2020 Peer-reviewed
Effects of Oral Administration of Lactobacillus reuteri on Mucosal Barrier Function in the Digestive Tract of Broiler Chicks

Nii, Takahiro, Jirapat, Jirapat, Isobe, Naoki, Yoshimura, Yukinori

JOURNAL OF POULTRY SCIENCE, 57(1) 67-76, Jan, 2020 Peer-reviewed

Books and Other Publications

SDGsに向けた生物生産学入門

(Role: Joint author)

共立出版株式会社, Nov 30, 2021
養鶏の友2021年10月号

日本畜産振興会, Oct 1, 2021
つくると食べるをつなぐサイエンス

(Role: Joint author)

恒星社厚生閣
養鶏の友2022年12月号

新居隆浩

Presentations

Establishment of primary culture system of chicken Peyer's patch cells and its IgA production ability.

Takahiro Nii, Anis Zaid, Yoshinari Yamamoto

Mar 29, 2023
Lactobacillus johnsoniiの経口投与によるニワトリ卵管粘膜のバリア機能強化に関する研究.

新小田太郎、津上優作、磯部直樹、新居隆浩

第46回鳥類内分泌研究会, Dec 11, 2022
Lactobacillus johnsonii の経口投与が産卵鶏の卵管および腸管の粘膜バリア機能に及ぼす影響.

新小田太郎, 津上優作, 磯部直樹, 吉村幸則, 新居隆浩

日本家禽学会2022年度春季大会, Mar 29, 2022
産卵鶏の加齢が腸管および卵管粘膜の細菌叢と炎症反応に及ぼす影響.

杉浦拓己, 鈴木直樹, 津上優作, 磯部直樹, 吉村幸則, 新居隆浩

日本家禽学会2022年度春季大会, Mar 29, 2022
Effects of intra-vaginal administration of lactic acid bacteria on the oviductal mucosal barrier function of the laying hens.

Shinkoda T, Isobe N, Yoshimura Y, Nii T

The 9th International Seminar on Tropical Animal Production, Sep 21, 2021
Effects of Partially Hydrolyzed Guar Gum Feeding on Intestinal Environment of Laying Hens.

Takahiro Nii

The 9th International Seminar on Tropical Animal Production (ISTAP), Sep 21, 2021
Lactobacillus johnsonii の経腟投与が卵管の粘膜バリア機能に及ぼす影響.

新小田太郎, 磯部直樹, 吉村幸則, 新居隆浩

日本家禽学会2021年度秋季大会, Sep 16, 2021
グァーガム分解物給与が腸内環境悪化モデル産卵鶏の産卵機能に及ぼす影響

新居隆浩

日本畜産学会第129回大会, Sep 14, 2021

Professional Memberships

Research Projects

Improvement of gut health to make chickens strong against stress

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
Prediction of mastitis using antimicrobial components.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Enhancement of hen and chick mucosal barrier function focused on oviductal microbiota.

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
家禽飼料用DHA・EPAサプリメントの植物性食品廃棄物からの製造

研究開発事業, 特定非営利活動法人広島循環型社会推進機構, Apr, 2021 - Mar, 2022

中井智司
スラウストキトリッドの脂質生産特性の評価と食品残渣のエコフィード化促進への応用

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

中井智司, 西嶋渉, 新居隆浩
Study of the network among the intestine, brain and reproductive organs focused on the intestinal environment in hens.

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021
Strategy for enhancing the egg production by probiotics based on the network among the brain, intestine and reproductive organs in hens

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2017 - Mar, 2019
ニワトリ卵管のナチュラルキラー細胞を介する免疫機構の解明

科学研究費助成事業特別研究員奨励費, 日本学術振興会, Apr, 2013 - Mar, 2015

新居隆浩