谷村奈津子 (Natsuko TANIMURA) - マイポータル

Cleavage of toll-like receptor 9 ectodomain is required for in vivo responses to single strand DNA

Ryutaro Fukui, Chikako Yamamoto, Fumi Matsumoto, Masahiro Onji, Takuma Shibata, Yusuke Murakami, Atsuo Kanno, Takuto Hayashi, Natsuko Tanimura, Nobuaki Yoshida …

Frontiers in Immunology 9 1491 2018年6月27日査読有り

TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Shin-Ichiroh Saitoh, Fumiko Abe, Atsuo Kanno, Natsuko Tanimura, Yoshiko Mori Saitoh, Ryutaro Fukui, Takuma Shibata, Katsuaki Sato, Takeshi Ichinohe, Mayumi Hayashi …

NATURE COMMUNICATIONS 8(1) 1592 2017年11月査読有り

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

Naoki Okamoto, Keisuke Mizote, Hiroe Honda, Akinori Saeki, Yasuharu Watanabe, Tomonni Yamaguchi-Miyamoto, Ryutaro Fukui, Natsuko Tanimura, Yuji Motoi, Sachiko Akashi-Takamura …

JOURNAL OF BIOLOGICAL CHEMISTRY 292(37) 15378-15394 2017年9月査読有り

Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes

Xiaobing Li, Shin-ichiroh Saitoh, Takuma Shibata, Natsuko Tanimura, Ryutaro Fukui, Kensuke Miyake

INTERNATIONAL IMMUNOLOGY 27(2) 83-94 2015年2月査読有り

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

Atsuo Kanno, Natsuko Tanimura, Masayuki Ishizaki, Kentaro Ohko, Yuji Motoi, Masahiro Onji, Ryutaro Fukui, Takaichi Shimozato, Kazuhide Yamamoto, Takuma Shibata …

NATURE COMMUNICATIONS 6 6119 2015年2月査読有り

Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing

Yusuke Murakami, Ryutaro Fukui, Yuji Motoi, Atsuo Kanno, Takuma Shibata, Natsuko Tanimura, Shin-ichiroh Saitoh, Kensuke Miyake

JOURNAL OF IMMUNOLOGY 193(10) 5208-5217 2014年11月査読有り

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane

Natsuko Tanimura, Shin-ichiroh Saitoh, Umeharu Ohto, Sachiko Akashi-Takamura, Yukari Fujimoto, Koichi Fukase, Toshiyuki Shimizu, Kensuke Miyake

INTERNATIONAL IMMUNOLOGY 26(6) 307-314 2014年6月査読有り

Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner.

Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y

Journal of immunology (Baltimore, Md. : 1950) 191(4) 1856-1864 2013年8月15日査読有り

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A

Natsuko Yamakawa, Umeharu Ohto, Sachiko Akashi-Takamura, Koichiro Takahashi, Shin-Ichiroh Saitoh, Natsuko Tanimura, Takayoshi Suganami, Yoshihiro Ogawa, Takuma Shibata, Toshiyuki Shimizu …

INTERNATIONAL IMMUNOLOGY 25(1) 45-52 2013年1月査読有り

PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells

Takuma Shibata, Naoki Takemura, Yuji Motoi, Yoshiyuki Goto, Thangaraj Karuppuchamy, Kumi Izawa, Xiaobing Li, Sachiko Akashi-Takamura, Natsuko Tanimura, Jun Kunisawa …

INTERNATIONAL IMMUNOLOGY 24(10) 613-623 2012年10月査読有り

Chemical Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures and their Selective Proinflammatory Responses

Atsushi Shimoyama, Akinori Saeki, Natsuko Tanimura, Hiroko Tsutsui, Kensuke Miyake, Yasuo Suda, Yukari Fujimoto, Koichi Fukase

CHEMISTRY-A EUROPEAN JOURNAL 17(51) 14464-14474 2011年12月査読有り

Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes

Takuma Shibata, Yuji Motoi, Natsuko Tanimura, Natsuko Yamakawa, Sachiko Akashi-Takamura, Kensuke Miyake

INTERNATIONAL IMMUNOLOGY 23(8) 503-510 2011年8月査読有り

High-Density Lipoprotein Suppresses the Type I Interferon Response, a Family of Potent Antiviral Immunoregulators, in Macrophages Challenged With Lipopolysaccharide

Masashi Suzuki, David K. Pritchard, Lev Becker, Andrew N. Hoofnagle, Natsuko Tanimura, Theo K. Bammler, Richard P. Beyer, Roger Bumgarner, Tomas Vaisar, Maria C. de Beer …

CIRCULATION 122(19) 1919-U77 2010年11月査読有り

Palmitoylation-Dependent Plasma Membrane Transport but Lipid Raft-Independent Signaling by Linker for Activation of T Cells

Matthias Hundt, Yohsuke Harada, Lauren De Giorgio, Natsuko Tanimura, Weiguo Zhang, Amnon Altman

JOURNAL OF IMMUNOLOGY 183(3) 1685-1694 2009年8月査読有り

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

Natsuko Tanimura, Shinichiroh Saitoh, Fumi Matsumoto, Sachiko Akashi-Takamura, Kensuke Miyake

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 368(1) 94-99 2008年3月査読有り

Cathepsins are required for Toll-like receptor 9 responses

Matsumoto F, Saitoh S, Fukui R, Kobayashi T, Tanimura N, Konno K, Kusumoto Y, Akashi-Takamura S, Miyake K

BBRC 368(3) 693-699 2008年3月査読有り

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

Koichiro Takahashi, Takuma Shibata, Sachiko Akashi-Takamura, Takashi Kiyokawa, Yasutaka Wakabayashi, Natsuko Tanimura, Toshihiko Kobayashi, Fumi Matsumoto, Ryutaro Fukui, Taku Kouro …

JOURNAL OF EXPERIMENTAL MEDICINE 204(12) 2963-2976 2007年11月査読有り

A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4

Yasutaka Wakabayashi, Makiko Kobayashi, Sachiko Akashi-Takamura, Natsuko Tanimura, Kazunori Konno, Koichiro Takahashi, Takashi Ishii, Taketoshi Mizutani, Hideo Iba, Taku Kouro …

JOURNAL OF IMMUNOLOGY 177(3) 1772-1779 2006年8月査読有り

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

M Kobayashi, SI Saitoh, N Tanimura, K Takahashi, K Kawasaki, M Nishijima, Y Fujimoto, K Fukase, S Akashi-Takamura, K Miyake

JOURNAL OF IMMUNOLOGY 176(10) 6211-6218 2006年5月査読有り

Agonistic antibody to TLR4/MD-2 protects mice from acute lethal hepatitis induced by TNF-alpha

Sachiko Akashi-Takamura, Takahisa Furuta, Koichiro Takahashi, Natsuko Tanimura, Yutaka Kusumoto, Toshihiko Kobayashi, Shin-ichiroh Saitoh, Yoshiyuki Adachi, Takahiro Doi, Kensuke Miyake

JOURNAL OF IMMUNOLOGY 176(7) 4244-4251 2006年4月査読有り

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