論文

査読有り
2013年10月

High Dietary Fat Intake during Lactation Promotes Development of Diet-Induced Obesity in Male Offspring of Mice

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
  • Tsuyoshi Tsuduki
  • ,
  • Yasuna Kitano
  • ,
  • Taro Honma
  • ,
  • Ryo Kijima
  • ,
  • Ikuo Ikeda

59
5
開始ページ
384
終了ページ
392
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3177/jnsv.59.384
出版者・発行元
CENTER ACADEMIC PUBL JAPAN

The maternal nutritional status during pregnancy and lactation influences the risk of obesity in offspring, but the details of this phenomenon are unclear. In particular, there is little information on the influence on the offspring of the maternal nutritional status during lactation only. Therefore, in this study, we examined the influence of high dietary fat intake in dams during lactation on the risk of obesity in offspring, using C57BL/6J mice. The mice were fed a control diet (CD) during pregnancy. After birth, dams were fed a CD or a high-fat diet (HD) during lactation (3 wk). Fat and energy were significantly increased in milk from dams fed a HD during lactation. Male offspring were weaned at 3 wk old and fed a CD for 4 wk, which resulted in no significant difference in their physique. Four weeks after weaning, the offspring (7 wk old) were fed a CD or HD for 4 wk to induce obesity. High dietary fat intake in dams and offspring promoted lipid accumulation in white adipose tissue and adipocyte hypertrophy in male offspring. The underlying mechanism may involve an increase in expression of Lpl and a decrease in expression of Hsl in white adipose tissue of offspring. In conclusion, our results show that high dietary fat intake during lactation promotes development of diet-induced obesity in male offspring.

リンク情報
DOI
https://doi.org/10.3177/jnsv.59.384
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24418872
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000326487400003&DestApp=WOS_CPL
ID情報
  • DOI : 10.3177/jnsv.59.384
  • ISSN : 0301-4800
  • eISSN : 1881-7742
  • PubMed ID : 24418872
  • Web of Science ID : WOS:000326487400003

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