2012年3月
Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- 巻
- 50
- 号
- 2
- 開始ページ
- 152
- 終了ページ
- 157
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3164/jcbn.11-29
- 出版者・発行元
- JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid beta-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.
- リンク情報
- ID情報
-
- DOI : 10.3164/jcbn.11-29
- ISSN : 0912-0009
- eISSN : 1880-5086
- PubMed ID : 22448097
- Web of Science ID : WOS:000302525900009