論文

査読有り
2015年9月

Structural, functional, and evolutionary aspects of galectins in aquatic mollusks: From a sweet tooth to the Trojan horse

FISH & SHELLFISH IMMUNOLOGY
  • G. R. Vasta
  • ,
  • C. Feng
  • ,
  • M. A. Bianchet
  • ,
  • T. R. Bachvaroff
  • ,
  • S. Tasumi

46
1
開始ページ
94
終了ページ
106
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.fsi.2015.05.012
出版者・発行元
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Galectins constitute a conserved and widely distributed lectin family characterized by their binding affinity for beta-galactosides and a unique binding site sequence motif in the carbohydrate recognition domain (CRD). In spite of their structural conservation, galectins display a remarkable functional diversity, by participating in developmental processes, cell adhesion and motility, regulation of immune homeostasis, and recognition of glycans on the surface of viruses, bacteria and protozoan parasites. In contrast with mammals, and other vertebrate and invertebrate taxa, the identification and characterization of bona fide galectins in aquatic mollusks has been relatively recent. Most of the studies have focused on the identification and domain organization of galectin-like transcripts or proteins in diverse tissues and cell types, including hemocytes, and their expression upon environmental or infectious challenge. Lectins from the eastern oyster Crassostrea virginica, however, have been characterized in their molecular, structural and functional aspects and some notable features have become apparent in the galectin repertoire of aquatic mollusks. These including less diversified galectin repertoires and different domain organizations relative to those observed in vertebrates, carbohydrate specificity for blood group oligosaccharides, and up regulation of galectin expression by infectious challenge, a feature that supports their proposed role(s) in innate immune responses. Although galectins from some aquatic mollusks have been shown to recognize microbial pathogens and parasites and promote their phagocytosis, they can also selectively bind to phytoplankton components, suggesting that they also participate in uptake and intracellular digestion of microalgae. In addition, the experimental evidence suggests that the protozoan parasite Perkinsus marinus has co-evolved with the oyster host to be selectively recognized by the oyster hemocyte galectins over algal food or bacterial pathogens, thereby subverting the oyster's innate immune/feeding recognition mechanisms to gain entry into the host cells. (C) 2015 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 36

リンク情報
DOI
https://doi.org/10.1016/j.fsi.2015.05.012
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25982395
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509915
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000358805300010&DestApp=WOS_CPL
URL
http://europepmc.org/abstract/med/25982395
URL
http://orcid.org/0000-0003-3047-6942