2010年7月
A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- 巻
- 107
- 号
- 30
- 開始ページ
- 13408
- 終了ページ
- 13413
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.1005475107
- 出版者・発行元
- NATL ACAD SCIENCES
Adaptive immunity in jawless vertebrates is mediated by leucine-rich repeat proteins called "variable lymphocyte receptors" (VLRs). Two types of VLR (A and B) are expressed by mutually exclusive lymphocyte populations in lamprey. VLRB lymphocytes resemble the B cells of jawed vertebrates; VLRA lymphocytes are similar to T cells. We determined the structure of a high-affinity VLRA isolated from lamprey immunized with hen egg white lysozyme (HEL) in unbound and antigen-bound forms. The VLRA-HEL complex demonstrates that certain VLRAs, like gamma delta T-cell receptors (TCRs) but unlike alpha beta TCRs, can recognize antigens directly, without a requirement for processing orantigen-presenting molecules. Thus, these VLRAs feature the nanomolar affinities of antibodies, the direct recognition of unprocessed antigens of both antibodies and gamma delta TCRs, and the exclusive expression on the lymphocyte surface that is unique to alpha beta and gamma delta TCRs.
- リンク情報
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- DOI
- https://doi.org/10.1073/pnas.1005475107
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20616002
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922149
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000280602800041&DestApp=WOS_CPL
- URL
- http://europepmc.org/abstract/med/20616002
- URL
- http://orcid.org/0000-0003-3047-6942
- ID情報
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- DOI : 10.1073/pnas.1005475107
- ISSN : 0027-8424
- ORCIDのPut Code : 31795792
- PubMed ID : 20616002
- PubMed Central 記事ID : PMC2922149
- Web of Science ID : WOS:000280602800041