論文

査読有り
2018年12月1日

Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS): first analysis on survival

International Journal of Clinical Oncology
  • Kazuto Ito
  • Shiro Saito
  • Atsunori Yorozu
  • Shinsuke Kojima
  • Takashi Kikuchi
  • Satoshi Higashide
  • Manabu Aoki
  • Hirofumi Koga
  • Takefumi Satoh
  • Toshio Ohashi
  • Katsumasa Nakamura
  • Norihisa Katayama
  • Nobumichi Tanaka
  • Masahiro Nakano
  • Naoyuki Shigematsu
  • Takushi Dokiya
  • Masanori Fukushima
  • Yutaka Takahashi
  • Iwao Tsukiyama
  • Yasutomo Nasu
  • Masaoki Harada
  • Takashi Fukagai
  • Takashi Yamashita
  • Akio Matsubara
  • Mikio Igawa
  • Shin Egawa
  • Yoshiyuki Kakehi
  • Youji Katsuoka
  • Hiroshi Kanetake
  • Yoshinobu Kubota
  • Hiromi Kumon
  • Ichiro Yamasaki
  • Kazuhiro Suzuki
  • Takashi Deguchi
  • Munehisa Ueno
  • Seiji Naito
  • Mikio Namiki
  • Shiro Baba
  • Kazushige Hayakawa
  • Yoshihiko Hirao
  • Tomoaki Fujioka
  • Shigeo Horie
  • Tsuneharu Miki
  • Masaru Murai
  • Hideki Yoshida
  • Jun Itami
  • Toshihiko Inoue
  • Yutaka Imai
  • Masaaki Kataoka
  • Atsushi Kubo
  • Hitoshi Shibuya
  • Masamichi Nishio
  • Hiroyoshi Tanaka
  • Yoshiaki Tanaka
  • Satoshi Teramukai
  • Chikako Harada
  • Kouichi Yamashiro
  • Takayoshi Kiba
  • Shin ichi Kitagawa
  • Emiko Uno
  • Tsutomu Nishimura
  • Fumie Kinoshita
  • Shinya Iida
  • Shinichiro Maruo
  • Keiko Miyakoda
  • Takashi Daimon
  • Atsuhiko Kawamoto
  • Hideaki Kaneda
  • Mikio Yoshidomi
  • Toru Nishiyama
  • Yasuto Yagi
  • Ryo Namitome
  • Kazuhito Toya
  • Naoyoshi Koike
  • Kayo Yoshida
  • Kenichi Tabata
  • Hideyasu Tsumura
  • Masaki Kimura
  • Hiromichi Ishiyama
  • Shouko Kotani
  • Hideaki Kondo
  • Kiyohide Fujimoto
  • Masatoshi Hasegawa
  • Tetsuro Tamamoto
  • Isao Asakawa
  • Shuji Nishizawa
  • Iwao Hashida
  • Yutaka Takezawa
  • Kousaku Harada
  • Susumu Tanji
  • Kensuke Sato
  • Tomohiko Matsuura
  • Hisanori Ariga
  • Shigeru Ehara
  • Ryuji Nakamura
  • Shinya Hayashi
  • Kazuhiro Ohtakara
  • Kazunori Kihara
  • Keiji Hayashi
  • Keisei Okamoto
  • 全て表示

23
6
開始ページ
1148
終了ページ
1159
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10147-018-1309-0

© 2018, Japan Society of Clinical Oncology. Background: Investigating oncological outcomes in patients registered in the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS) in terms of biochemical relapse-free survival (bRFS) by the Phoenix and the newly developed J-POPS definitions, exploration of predictive factors for bRFS, and preliminary verification of pitfalls of prostate-specific antigen (PSA) failure definitions. Methods: Between July 2005 and June 2007, 2316 clinically localized patients underwent permanent seed implantation. The primary endpoint was bRFS. One of the secondary endpoints was overall survival (OS). Results: The median age was 69 and performance status was 0 in 99.1% of participants. The median biologically effective dose (BED) was about 180 Gy 2 . During a median follow-up of 60.0 months, 8.4 and 5.9% had PSA failure by the Phoenix and the J-POPS definitions, respectively. The 5-year bRFSs based on the Phoenix and the J-POPS definitions were 89.1 and 91.6%, respectively. The 5-year OS was 97.3%. According to multivariate analyses, only age affected bRFS based on the Phoenix definition, whereas the risk group and BED independently affected bRFS based on the J-POPS definition. A spontaneous PSA decrease was seen in 91.1% of participants after PSA failure based on the Phoenix definition alone, but in only 22.2% after PSA failure based on the J-POPS definition alone. Conclusion: The world’s largest registration study, J-POPS, consisted of patients with longevity, and a highly quality-controlled BED resulted in excellent bRFS and OS. The high likelihood of PSA bounce by the Phoenix definition should be taken into account, especially in younger patients. Clinical trial information: NCT00534196.

リンク情報
DOI
https://doi.org/10.1007/s10147-018-1309-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29934842
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048863471&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85048863471&origin=inward
ID情報
  • DOI : 10.1007/s10147-018-1309-0
  • ISSN : 1341-9625
  • eISSN : 1437-7772
  • PubMed ID : 29934842
  • SCOPUS ID : 85048863471

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