論文

査読有り 国際誌
2020年8月12日

Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study

Scientific Reports
  • Ichiro Wakabayashi
  • ,
  • Ryoji Eguchi
  • ,
  • Yoko Sotoda
  • ,
  • Dirk von Lewinski
  • ,
  • Harald Sourij
  • ,
  • Takashi Daimon
  • ,
  • Klaus Groschner
  • ,
  • Peter P. Rainer

10
1
開始ページ
13628
終了ページ
13628
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-69332-0
出版者・発行元
Springer Science and Business Media LLC

Mortality from ischemic heart disease (IHD) is significantly lower in Japan than in Western countries. The purpose of this study was to investigate differences in circulating microRNA (miRNA) levels related to IHD in Austrians and Japanese. Participants were middle-aged healthy male Austrians (n = 20) and Japanese (n = 20). Total miRNAs in serum from each participant were analyzed using the 3D-Gene miRNA Oligo chip. Twenty-one miRNAs, previously reported as associated with IHD, were compared between Austrians and Japanese. The expression levels of miR-106a-5p, miR-135a-3p, miR-150-3p, miR-16-5p, miR-17-5p. miR-191-5p, miR-320b, miR-451a, miR-486-5p, miR-663b, and miR-92a-3p were significantly higher, while the miR-2861 expression level was significantly lower in Austrians as compared to Japanese. Both in Austrians and Japanese, there were significant positive correlations between serum expression levels of each pair of the above miRNAs except for miR-2861. The expression level of miR-2861 showed significant positive correlations with the expression levels of miR-106a-5p, miR-150-3p, miR-17-5p, miR-486-5p, miR-663b and miR-92a-3p in Austrians but not in Japanese. In pathway analysis, proinflammatory cytokine production in foam cells and collagen synthesis in vascular smooth muscle cells were associated with differentially expressed miRNAs. Difference in miRNA levels may contribute to lower cardiovascular risk in Japan than in Western countries.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-69332-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32788621
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423897
URL
http://www.nature.com/articles/s41598-020-69332-0.pdf
URL
http://www.nature.com/articles/s41598-020-69332-0
ID情報
  • DOI : 10.1038/s41598-020-69332-0
  • eISSN : 2045-2322
  • PubMed ID : 32788621
  • PubMed Central 記事ID : PMC7423897

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