論文

査読有り 国際誌
2019年9月

Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma.

Cancer science
  • Taichiro Yoshimoto
  • Daisuke Matsubara
  • Manabu Soda
  • Toshihide Ueno
  • Yusuke Amano
  • Atsushi Kihara
  • Takashi Sakatani
  • Tomoyuki Nakano
  • Tomoki Shibano
  • Shunsuke Endo
  • Koichi Hagiwara
  • Masashi Fukayama
  • Kaori Denda-Nagai
  • Tatsuro Irimura
  • Hiroyuki Mano
  • Toshiro Niki
  • 全て表示

110
9
開始ページ
3006
終了ページ
3011
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.14129

Decreased cell adhesion has been reported as a significant negative prognostic factor of lung cancer. However, the molecular mechanisms responsible for the cell incohesiveness in lung cancer have not yet been elucidated in detail. We herein describe a rare histological variant of lung adenocarcinoma consisting almost entirely of individual cancer cells spreading in alveolar spaces in an incohesive pattern. A whole exome analysis of this case showed no genomic abnormalities in CDH1 or other genes encoding cell adhesion molecules. However, whole mRNA sequencing revealed that this case had an extremely high expression level of mucin 21 (MUC21), a mucin molecule that was previously shown to inhibit cell-cell and cell-matrix adhesion. The strong membranous expression of MUC21 was found on cancer cells using mAbs recognizing different O-glycosylated forms of MUC21. An immunohistochemical analysis of an unselected series of lung adenocarcinoma confirmed that the strong membranous expression of MUC21 correlated with incohesiveness. Thus, MUC21 could be a promising biomarker with potential diagnostic and therapeutic applications for lung adenocarcinoma showing cell incohesiveness.

リンク情報
DOI
https://doi.org/10.1111/cas.14129
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31301084
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726699
ID情報
  • DOI : 10.1111/cas.14129
  • ISSN : 1347-9032
  • PubMed ID : 31301084
  • PubMed Central 記事ID : PMC6726699

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