Tatsushi Onaka

Last updated: Nov 30, 2018 at 14:15

Name	Tatsushi Onaka

Research Interests

Social behavior(17)

Awards & Honors

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2011

Mortyn Jones Lecturers, British Society for Neuroendocrinology

Published Papers

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Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice.

Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T

Nature communications 9(1) 4604 Nov 2018 [Refereed]

Upregulation of hypothalamic arginine vasopressin by peripherally administered furosemide in transgenic rats expressing arginine vasopressin-enhanced green fluorescent protein.

Ueno H, Yoshimura M, Tanaka K, Nishimura H, Nishimura K, Sonoda S, Motojima Y, Saito R, Maruyama T, Miyamoto T, Serino R, Tamura M, Onaka T, Otsuji Y, Ueta Y

Journal of neuroendocrinology e12603 Apr 2018 [Refereed]

Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.

Nakamura S, Muramatsu SI, Takino N, Ito M, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T, Osaka H

The journal of gene medicine 20(4) e3013 Apr 2018 [Refereed]

Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice.

Nasanbuyan N, Yoshida M, Takayanagi Y, Inutsuka A, Nishimori K, Yamanaka A, Onaka T

Endocrinology 159(2) 763-775 Feb 2018 [Refereed]

Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

Nakamura S, Osaka H, Muramatsu SI, Takino N, Ito M, Aoki S, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T

Molecular genetics and metabolism reports 10 67-74 Mar 2017 [Refereed]

Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition.

Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T

Biological psychiatry 81(3) 243-251 Feb 2017 [Refereed]

Activation of hypothalamic oxytocin neurons following tactile stimuli in rats.

Okabe S, Yoshida M, Takayanagi Y, Onaka T

Neuroscience letters 600 22-27 Jul 2015 [Refereed]

Effects of a subconvulsive dose of kainic acid on the gene expressions of the arginine vasopressin, oxytocin and neuronal nitric oxide synthase in the rat hypothalamus.

Yoshimura M, Ohkubo JI, Hashimoto H, Matsuura T, Maruyama T, Onaka T, Suzuki H, Ueta Y

Neuroscience research 99 62-68 May 2015 [Refereed]

Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds.

Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T

Science (New York, N.Y.) 348(6232) 333-336 Apr 2015 [Refereed]

Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors.

Onaka T, Okabe S, Takayanagi Y, Yoshida M

Interdisciplinary Information Sciences 21(3) 189-195 2015 [Refereed]

The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents.

Yoshida M, Takayanagi Y, Onaka T

Endocrinology 155(8) en20131411-3004 May 2014 [Refereed]

Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.

Ikeda K, Satake S, Onaka T, Sugimoto H, Takeda N, Imoto K, Kawakami K

The Journal of physiology 591(Pt 13) 3433-3449 Jul 2013 [Refereed]

Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake.

Yamashita M, Takayanagi Y, Yoshida M, Nishimori K, Kusama M, Onaka T

Journal of neuroendocrinology 25 455-465 May 2013 [Refereed]

Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders.

Tachibana M, Kagitani-Shimono K, Mohri I, Yamamoto T, Sanefuji W, Nakamura A, Oishi M, Kimura T, Onaka T, Ozono K, Taniike M

Journal of child and adolescent psychopharmacology 23(2) 123-127 Mar 2013 [Refereed]

Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour.

Onaka T, Takayanagi Y, Yoshida M

Journal of neuroendocrinology 24 587-598 Apr 2012 [Refereed]

Expression of exocytosis proteins in rat supraoptic nucleus neurones.

Tobin V, Schwab Y, Lelos N, Onaka T, Pittman QJ, Ludwig M

Journal of neuroendocrinology 24 629-641 Apr 2012 [Refereed]

Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats.

Katoh A, Fujihara H, Ohbuchi T, Onaka T, Hashimoto T, Kawata M, Suzuki H, Ueta Y

Endocrinology 152(7) 2768-2774 Jul 2011 [Refereed]

Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats.

Kaewwongse M, Takayanagi Y, Onaka T

Journal of neuroendocrinology 23(1) 20-27 Jan 2011 [Refereed]

Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake.

Takayanagi Y, Onaka T

The FEBS journal 277(24) 4998-5005 Dec 2010 [Refereed]

Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.

Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, Onaka T, Dezaki K, Nakata M, Mori M, Yada T

Aging 2(11) 775-784 Nov 2010 [Refereed]

Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotrophin-releasing hormone pathway in the paraventricular nucleus of the hypothalamus.

Toriya M, Maekawa F, Maejima Y, Onaka T, Fujiwara K, Nakagawa T, Nakata M, Yada T

Journal of neuroendocrinology 22 987-995 Sep 2010 [Refereed]

Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake.

Otsubo H, Onaka T, Suzuki H, Katoh A, Ohbuchi T, Todoroki M, Kobayashi M, Fujihara H, Yokoyama T, Matsumoto T, Ueta Y

Peptides 31(6) 1124-1130 Jun 2010 [Refereed]

Impairment of social and emotional behaviors in Cadm1-knockout mice.

Takayanagi Y, Fujita E, Yu Z, Yamagata T, Momoi MY, Momoi T, Onaka T

Biochemical and biophysical research communications 396(3) 703-708 Jun 2010 [Refereed]

Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland.

Suzuki H, Onaka T, Dayanithi G, Ueta Y

Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 17(2) 135-140 Apr 2010 [Refereed]

An intrinsic vasopressin system in the olfactory bulb is involved in social recognition.

Tobin VA, Hashimoto H, Wacker DW, Takayanagi Y, Langnaese K, Caquineau C, Noack J, Landgraf R, Onaka T, Leng G, Meddle SL, Engelmann M, Ludwig M

Nature 464(7287) 413-417 Mar 2010 [Refereed]

Specific expression of an oxytocin-enhanced cyan fluorescent protein fusion transgene in the rat hypothalamus and posterior pituitary.

Katoh A, Fujihara H, Ohbuchi T, Onaka T, Young WS 3rd, Dayanithi G, Yamasaki Y, Kawata M, Suzuki H, Otsubo H, Suzuki H, Murphy D, Ueta Y

The Journal of endocrinology 204(3) 275-285 Mar 2010 [Refereed]

Metabolic and stress-related roles of prolactin-releasing peptide.

Onaka T, Takayanagi Y, Leng G

Trends in endocrinology and metabolism: TEM 21(5) 287-293 Jan 2010 [Refereed]

Participation of the prolactin-releasing peptide-containing neurones in caudal medulla in conveying haemorrhagic stress-induced signals to the paraventricular nucleus of the hypothalamus.

Uchida K, Kobayashi D, Das G, Onaka T, Inoue K, Itoi K

Journal of neuroendocrinology 22 33-42 Jan 2010 [Refereed]

Central endogenous vasopressin induced by central salt-loading participates in body fluid homeostasis through modulatory effects on neurones of the paraventricular nucleus in conscious rats.

Kato K, Kannan H, Ohta H, Kemuriyama T, Maruyama S, Tandai-Hiruma M, Sato Y, Nakazato M, Nishimori T, Ishida Y, Onaka T, Nishida Y

Journal of neuroendocrinology 21 921-934 Nov 2009 [Refereed]

Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway.

Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh-I S, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T

Cell metabolism 10(5) 355-365 Nov 2009 [Refereed]

Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats.

Suzuki H, Onaka T, Kasai M, Kawasaki M, Ohnishi H, Otsubo H, Saito T, Hashimoto H, Yokoyama T, Fujihara H, Dayanithi G, Murphy D, Nakamura T, Ueta Y

Journal of neuroendocrinology 21 183-190 Mar 2009 [Refereed]

Dog's gaze at its owner increases owner's urinary oxytocin during social interaction.

Nagasawa M, Kikusui T, Onaka T, Ohta M

Hormones and behavior 55(3) 434-441 Mar 2009 [Refereed]

Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice.

Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K

The Journal of neuroscience : the official journal of the Society for Neuroscience 29(7) 2259-2271 Feb 2009 [Refereed]

Endogenous prolactin-releasing peptide regulates food intake in rodents.

Takayanagi Y, Matsumoto H, Nakata M, Mera T, Fukusumi S, Hinuma S, Ueta Y, Yada T, Leng G, Onaka T

The Journal of clinical investigation 118(12) 4014-4024 Dec 2008 [Refereed]

The single-prolonged stress paradigm alters both the morphology and stress response of magnocellular vasopressin neurons.

Yoshii T, Sakamoto H, Kawasaki M, Ozawa H, Ueta Y, Onaka T, Fukui K, Kawata M

Neuroscience 156 466-474 Oct 2008 [Refereed]

Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress.

Kawakami A, Okada N, Rokkaku K, Honda K, Ishibashi S, Onaka T

Stress (Amsterdam, Netherlands) 11(5) 363-369 Sep 2008 [Refereed]

Oxytocin receptor-deficient mice developed late-onset obesity.

Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K

Neuroreport 19(9) 951-955 Jun 2008 [Refereed]

Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding.

Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Yoshida N, Dezaki K, Onaka T, Mori M, Yada T

Endocrinology 149(3) 1295-1301 Mar 2008 [Refereed]

Chronic osmotic stimuli increase salusin-beta-like immunoreactivity in the rat hypothalamo-neurohypophyseal system: possible involvement of salusin-beta on [Ca2+]i increase and neurohypophyseal hormone release from the axon terminals.

Saito T, Dayanithi G, Saito J, Onaka T, Urabe T, Watanabe TX, Hashimoto H, Yokoyama T, Fujihara H, Yokota A, Nishizawa S, Hirata Y, Ueta Y

Journal of neuroendocrinology 20 207-219 Feb 2008 [Refereed]

Oxytocin and appetite.

Leng G, Onaka T, Caquineau C, Sabatier N, Tobin VA, Takayanagi Y

Progress in brain research 170 137-151 2008 [Refereed]

The differential effect of cyclosporine on hypnotic response and pain reaction in mice.

Sato Y, Onaka T, Kobayashi E, Seo N

Anesthesia and analgesia 105(5) 1489-93, table of contents Nov 2007 [Refereed]

Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats.

Mera T, Fujihara H, Saito J, Kawasaki M, Hashimoto H, Saito T, Shibata M, Onaka T, Tanaka Y, Oka T, Tsuji S, Ueta Y

Peptides 28(8) 1596-1604 Aug 2007 [Refereed]

Impact of cyclosporine upon emotional and social behavior in mice.

Sato Y, Takayanagi Y, Onaka T, Kobayashi E

Transplantation 83(10) 1365-1370 May 2007 [Refereed]

Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway.

Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T

Endocrinology 148(5) 2251-2263 May 2007 [Refereed]

Effects of the short chain sugar acid 2-buten-4-olide on the hypothalamo-pituitary-adrenal axis in normal and adjuvant-induced arthritic rats.

Kawasaki M, Onaka T, Saito J, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Okimoto N, Ohnishi H, Nakamura T, Ueta Y

Journal of neuroendocrinology 19 54-65 Jan 2007 [Refereed]

Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress.

Ohiwa N, Chang H, Saito T, Onaka T, Fujikawa T, Soya H

American journal of physiology. Regulatory, integrative and comparative physiology 292(1) R497-504 Jan 2007 [Refereed]

Exaggerated response of arginine vasopressin-enhanced green fluorescent protein fusion gene to salt loading without disturbance of body fluid homeostasis in rats.

Fujio T, Fujihara H, Shibata M, Yamada S, Onaka T, Tanaka K, Morita H, Dayanithi G, Kawata M, Murphy D, Ueta Y

Journal of neuroendocrinology 18 776-785 Oct 2006 [Refereed]

Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus.

Mera T, Fujihara H, Kawasaki M, Hashimoto H, Saito T, Shibata M, Saito J, Oka T, Tsuji S, Onaka T, Ueta Y

Neuroscience 141 1069-1086 Aug 2006 [Refereed]

Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats.

Kawasaki M, Onaka T, Nakazato M, Saito J, Mera T, Hashimoto H, Fujihara H, Okimoto N, Ohnishi H, Nakamura T, Ueta Y

The Journal of endocrinology 190(2) 213-223 Aug 2006 [Refereed]

The short chain sugar acid, 2-buten-4-olide, activates oxytocin-secreting neurons but not arginine vasopressin-secreting neurons in the hypothalamus of rats.

Kawasaki M, Yamaga C, Onaka T, Saito J, Mera T, Hashimoto H, Fujihara H, Okimoto N, Ohnishi H, Nakamura T, Ueta Y

Brain research 1086(1) 133-141 May 2006 [Refereed]

Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat.

Kuramochi M, Onaka T, Kohno D, Kato S, Yada T

Endocrinology 147(4) 1744-1752 Apr 2006 [Refereed]

Salt loading reduces hypothalamic noradrenaline release after noxious stimuli.

Takayanagi Y, Nishimori K, Onaka T

Neuroscience letters 391(1-2) 22-27 Dec 2005 [Refereed]

Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice.

Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM, Young LJ, Nishimori K

Proceedings of the National Academy of Sciences of the United States of America 102(44) 16096-16101 Nov 2005 [Refereed]

Hyperphagia and obesity in Na,K-ATPase alpha2 subunit-defective mice.

Kawakami K, Onaka T, Iwase M, Homma I, Ikeda K

Obesity research 13(10) 1661-1671 Oct 2005 [Refereed]

Cannabinoids modulate synaptic activity in the rat supraoptic nucleus.

Soya A, Serino R, Fujihara H, Onaka T, Ozaki Y, Saito T, Nakamura J, Ueta Y

Journal of neuroendocrinology 17 609-615 Sep 2005 [Refereed]

Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor.

Hashimoto H, Onaka T, Kawasaki M, Chen L, Mera T, Soya A, Saito T, Fujihara H, Sei H, Morita Y, Ueta Y

Autonomic neuroscience : basic & clinical 121(1-2) 16-25 Aug 2005 [Refereed]

Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormone-releasing hormone in the arcuate nucleus.

Kuramochi M, Kohno D, Onaka T, Kato S, Yada T

Regulatory peptides 126(1-2) 85-89 Mar 2005 [Refereed]

Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats.

Onaka T, Kuramochi M, Saito J, Ueta Y, Yada T

Neuroreport 16(3) 243-247 Feb 2005 [Refereed]

Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons.

Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, Toyoda H, Arata A, Ishikawa TO, Taketo MM, Fukuda A, Kawakami K

The Journal of neuroscience : the official journal of the Society for Neuroscience 24(47) 10693-10701 Nov 2004 [Refereed]

Neural pathways controlling central and peripheral oxytocin release during stress.

Onaka T

Journal of neuroendocrinology 16 308-312 Apr 2004 [Refereed]

Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus.

Onaka T, Ikeda K, Yamashita T, Honda K

The European journal of neuroscience 18(11) 3018-3026 Dec 2003 [Refereed]

Involvement of novel feeding-related peptides in neuroendocrine response to stress.

Ueta Y, Ozaki Y, Saito J, Onaka T

Experimental biology and medicine (Maywood, N.J.) 228(10) 1168-1174 Nov 2003 [Refereed]

Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors.

Rokkaku K, Onaka T, Okada N, Ideno J, Kawakami A, Honda K, Yada T, Ishibashi S

Neuroreport 14(15) 1997-2000 Oct 2003 [Refereed]

Intermittent footshock facilitates dendritic vasopressin release but suppresses vasopressin synthesis within the rat supraoptic nucleus.

Onaka T, Serino R, Ueta Y

Journal of neuroendocrinology 15 629-632 Jul 2003 [Refereed]

Effects of novelty stress on neuroendocrine activities and running performance in thoroughbred horses.

Hada T, Onaka T, Takahashi T, Hiraga A, Yagi K

Journal of neuroendocrinology 15 638-648 Jul 2003 [Refereed]

Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice.

Ikeda K, Onaka T, Yamakado M, Nakai J, Ishikawa TO, Taketo MM, Kawakami K

The Journal of neuroscience : the official journal of the Society for Neuroscience 23(11) 4667-4676 Jun 2003 [Refereed]

Facilitative role of prolactin-releasing peptide neurons in oxytocin cell activation after conditioned-fear stimuli.

Zhu LL, Onaka T

Neuroscience 118 1045-1053 2003 [Refereed]

Involvement of medullary A2 noradrenergic neurons in the activation of oxytocin neurons after conditioned fear stimuli.

Zhu L, Onaka T

The European journal of neuroscience 16(11) 2186-2198 Dec 2002 [Refereed]

Centrally administered neuromedin U activates neurosecretion and induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat.

Ozaki Y, Onaka T, Nakazato M, Saito J, Kanemoto K, Matsumoto T, Ueta Y

Endocrinology 143(11) 4320-4329 Nov 2002 [Refereed]

Activation of orexin neurones after noxious but not conditioned fear stimuli in rats.

Zhu L, Onaka T, Sakurai T, Yada T

Neuroreport 13(10) 1351-1353 Jul 2002 [Refereed]

Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus.

Yamashita T, Liu X, Onaka T, Honda K, Saito T, Yagi K

Neuroreport 12 3509-3511 Nov 2001 [Refereed]

Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus.

Liu X, Onaka T, Yagi K

Journal of neuroendocrinology 13 894-904 Oct 2001 [Refereed]

Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: an experimental and theoretical analysis.

Leng G, Brown CH, Bull PM, Brown D, Scullion S, Currie J, Blackburn-Munro RE, Feng J, Onaka T, Verbalis JG, Russell JA, Ludwig M

The Journal of neuroscience : the official journal of the Society for Neuroscience 21 6967-6977 Sep 2001 [Refereed]

Involvement of N-methyl-D-aspartic acid receptor activation in oxytocin and vasopressin release after osmotic stimuli in rats.

Onaka T, Yagi K

Journal of neuroendocrinology 13 166-174 Feb 2001 [Refereed]

Effects of novel environmental stimuli on neuroendocrine activity in thoroughbred horses.

Hada T, Onaka T, Kusunose R, Yagi K.

J Equine Sci, 12(2) 33-38 2001 [Refereed]

Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: an experimental and theoretical analysis.

Leng G, Brown CH, Bull PM, Brown D, Scullion S, Currie J, Blackburn-Munro RE, Feng J, Onaka T, Verbalis JG, Russell JA, Ludwig M.

J Neurosci 21 6967-6977 2001 [Refereed]

Involvement of N-methyl-D-aspartic acid receptor activation in oxytocin and vasopressin release after osmotic stimuli in rats.

Onaka T, Yagi K

J Neuroendocrinol 13 166-174 2001 [Refereed]

Medullary A1 noradrenergic neurones may mediate oxytocin release after noxious stimuli.

Onaka T, Yamashita T, Liu X, Honda K, Saito T, Yagi K.

Neuroreport 12 2499-2502 2001 [Refereed]

Facilitation of Ca2+ store-dependent noradrenaline release after an NMDA receptor antagonist in the rat supraoptic nucleus.

Xiu L, Onaka T, Yagi K.

J Neuroendocrinol 13 894-904 2001 [Refereed]

Nicotine facilitates noradrenaline release in the rat supraoptic nucleus.

Xiu L, Onaka T, Yagi K

Neuroreport 12 641-643 2001 [Refereed]

Vasopressin regulation of noradrenaline release within the supraoptic nucleus.

Ludwig M, Onaka T, Yagi K

Journal of neuroendocrinology 12 477-479 Jun 2000 [Refereed]

Catecholaminergic mechanisms underlying neurohypophysial hormone responses to unconditioned or conditioned aversive stimuli in rats.

Onaka T

Experimental physiology 85 Spec No 101S-110S Mar 2000 [Refereed]

Vasopressin regulation of noradrenaline release within the supraoptic nucleus.

Ludwig M, Onaka T, Yagi K

J Neuroendocrinol 12 477-479 2000 [Refereed]

Catecholaminergic mechanisms underlying neurohypophysial hormone responses to unconditioned or conditioned aversive stimuli

Onaka T

Exp Physiol 85S 101S-110S 2000 [Refereed][Invited]

Does the pineal gland play a role in neuroendocrine fear responses?

Yagi K, Onaka T

Neuroreport 10 771-774 Mar 1999 [Refereed]

Role of adrenoceptors in vasopressin, oxytocin and prolactin responses to conditioned fear stimuli in the rat.

Zou CJ, Onaka T, Yagi K

Journal of neuroendocrinology 10 905-910 Dec 1998 [Refereed]

Oxytocin release from the neurohypophysis after the taste stimuli previously paired with intravenous cholecystokinin in anaesthetized rats.

Onaka T, Yagi K

Journal of neuroendocrinology 10 309-316 Apr 1998 [Refereed]

Effects of suramin on neuroendocrine and behavioural responses to conditioned fear stimuli.

Zou CJ, Onaka TO, Yagi K

Neuroreport 9 997-999 Apr 1998 [Refereed]

Role of NMDA receptors in the emotional memory associated with neuroendocrine responses to conditioned fear stimuli in the rat.

Yagi K, Onaka T, Yoshida A

Neuroscience research 30 279-286 Mar 1998 [Refereed]

Role of noradrenergic projections to the bed nucleus of the stria terminalis in neuroendocrine and behavioral responses to fear-related stimuli in rats.

Onaka T, Yagi K

Brain research 788 287-293 Mar 1998 [Refereed]

Role of N-methyl-D-aspartate (NMDA) receptors in vasopressin and oxytocin responses to emotional stimuli.

Yagi K, Onaka T, Yoshida A

Advances in experimental medicine and biology 449 131-134 1998 [Refereed]

The role of afferent inputs to supraoptic nucleus oxytocin neurons during naloxone-precipitated morphine withdrawal in the rat.

Murphy NP, Onaka T, Brown CH, Leng G

Neuroscience 80 567-577 Sep 1997 [Refereed]

A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat.

Onaka T, Palmer JR, Yagi K

Neuroscience research 25 67-75 May 1996 [Refereed]

Norepinephrine depletion impairs neuroendocrine responses to fear but not novel environmental stimuli in the rat.

Onaka T, Palmer JR, Yagi K

Brain research 713 261-268 Mar 1996 [Refereed]

A benzodiazepine, chlordiazepoxide, blocks vasopressin and oxytocin release after footshocks but not osmotic stimulus in the rat.

Yagi K, Onaka T

Neuroscience letters 203 49-52 Jan 1996 [Refereed]

Chlordiazepoxide discriminates between the neural circuits mediating neuroendocrine responses to fear- and anxiety-producing stimuli in the rat.

Yagi K, Onaka T

Neuroscience research 24 151-158 Jan 1996 [Refereed]

Involvement of the noradrenergic afferents from the nucleus tractus solitarii to the supraoptic nucleus in oxytocin release after peripheral cholecystokinin octapeptide in the rat.

Onaka T, Luckman SM, Antonijevic I, Palmer JR, Leng G

Neuroscience 66 403-412 May 1995 [Refereed]

Presynaptic actions of morphine: blockade of cholecystokinin-induced noradrenaline release in the rat supraoptic nucleus.

Onaka T, Luckman SM, Guevara-Guzman R, Ueta Y, Kendrick K, Leng G

The Journal of physiology 482 ( Pt 1) 69-79 Jan 1995 [Refereed]

Opioid-noradrenergic interactions in the control of oxytocin cells.

Leng G, Brown CH, Murphy NP, Onaka T, Russell JA

Advances in experimental medicine and biology 395 95-104 1995 [Refereed]

Effects of novelty stress on vasopressin and oxytocin secretion by the pituitary in the rat.

Onaka T, Yagi K

Journal of neuroendocrinology 5 365-369 Aug 1993 [Refereed]

Misc

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肥満・肥満症の調節,発症に関わる因子摂食調節因子とその作用機序摂食抑制因子脳由来オキシトシンとウロコルチンによる摂食制御

高柳友紀, 尾仲達史

日本臨床 72 224-230 May 2014

Research Grants & Projects

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nvestigation of the neuroendocrinological basis involved in the human paternal and maternal behaviors

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))

Project Year: 2009 - 2012 Investigator(s): Kazuyuki SHINOHARA

The purpose of the present study is to determine the biological basis for paternal and maternal behavior and to clarify the characteristics of their specific brain and hormone functions. We examined whether the brain activation patterns in respons...

Physiological function of Na pumpα3 subunit gene and involvement in pathophysiology of dystonia parkinsonism.

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))

Project Year: 2009 - 2011 Investigator(s): Kiyoshi KAWAKAMI

Dystonia is characterized by excessive involuntary and prolonged simultaneous contractions of both agonist and antagonist muscles. One hereditary form of dystonia, DYT12, is caused by loss of function mutations of the gene forα3 isoform of Na pump...

Roles of the PrRP-oxytocin pathway in the control of stress and social behaviour

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))

Project Year: 2008 - 2010 Investigator(s): Tatsushi ONAKA

Not only stressful stimuli but also food intake activated PrRP-synthesizing neurons and oxytocin-synthesizing neurons. Social stimuli activated oxytocin-synthesizing neurons. PrRP-synthesizing neurons were suggested to have stress-modulating and a...

Role of PrRP neurons in the control of food intake and emotional responses

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))

Project Year: 2006 - 2007 Investigator(s): Tatsushi ONAKA

Prolactin-releasing peptide (PrRP) is synthesized in the noradrenergic neurons of the medulla oblongata. We have previously shown that both a peripheral satiety signal, cholecystokinin octapeptide (CCK) and stressful stimuli activate noradrenergic...

Role of newly found brain stem neuropeptide on exercise-induced stress response and performance.

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))

Project Year: 2006 - 2007 Investigator(s): Hideaki SOYA

Running stimulates ACTH release when speed is beyond the lactate threshold (LT), the breakpoint for blood lactate accumulation appears to be around 50-60% of maximal oxygen uptake, defined as running stress. Although the exact brain mechanism unde...