Tatsuya Suzuki

Profile Information

Affiliation: Assistant Professor, Graduate School of Medicine Department of Microbiology, Juntendo University

Degree: 医学博士(大阪大学)

J-GLOBAL ID: 201801003264494203
researchmap Member ID: B000347231

Research Areas

Life sciences / Virology /

Papers

A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo

Brandon Havranek, Graeme Walker Lindsey, Yusuke Higuchi, Yumi Itoh, Tatsuya Suzuki, Toru Okamoto, Atsushi Hoshino, Erik Procko, Shahidul M. Islam

Communications Biology, 6(1), May 12, 2023
Stimulation of IFN-β responses by aberrant SARS-CoV-2 small viral RNAs acting as RIG-I agonists.

Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tatsuya Suzuki, Tomo Daidoji, Takao Ono, Takaaki Nakaya …

iScience, 105742-105742, Dec 7, 2022
SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.

Masako Kohyama, Tatsuya Suzuki, Wataru Nakai, Chikako Ono, Sumiko Matsuoka, Koichi Iwatani, Yafei Liu, Yusuke Sakai, Atsushi Nakagawa, Keisuke Tomii …

International immunology, 35(1) 43-52, Sep 2, 2022 Peer-reviewed
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo.

Nariko Ikemura, Shunta Taminishi, Tohru Inaba, Takao Arimori, Daisuke Motooka, Kazutaka Katoh, Yuhei Kirita, Yusuke Higuchi, Songling Li, Tatsuya Suzuki …

Science translational medicine, 14(650) eabn7737, Jun 22, 2022 Peer-reviewed
Cell response analysis in SARS-CoV-2 infected bronchial organoids.

Emi Sano, Tatsuya Suzuki, Rina Hashimoto, Yumi Itoh, Ayaka Sakamoto, Yusuke Sakai, Akatsuki Saito, Daisuke Okuzaki, Daisuke Motooka, Yukiko Muramoto …

Communications biology, 5(1) 516-516, May 30, 2022 Peer-reviewedLead author
SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication.

Yoichi Miyamoto, Yumi Itoh, Tatsuya Suzuki, Tomohisa Tanaka, Yusuke Sakai, Masaru Koido, Chiaki Hata, Cai-Xia Wang, Mayumi Otani, Kohji Moriishi …

Communications biology, 5(1) 483-483, May 19, 2022 Peer-reviewed
Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus.

He Zhang, Yumi Itoh, Tatsuya Suzuki, Kan-Ichiro Ihara, Tomohisa Tanaka, Saori Haga, Hajime Enatsu, Maho Yumiya, Mari Kimura, Akira Takada …

Microbiology and immunology, 66(4) 179-192, Apr 1, 2022 Peer-reviewed
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.

Tomohisa Tanaka, Akatsuki Saito, Tatsuya Suzuki, Yoichi Miyamoto, Kazuo Takayama, Toru Okamoto, Kohji Moriishi

Antiviral research, 199 105268-105268, Mar 1, 2022 Peer-reviewed
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Shunya Tsuji, Shohei Minami, Rina Hashimoto, Yusuke Konishi, Tatsuya Suzuki, Tamae Kondo, Miwa Sasai, Shiho Torii, Chikako Ono, Shintaro Shichinohe …

Nature Aging, 2(2) 115-124, Feb, 2022
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Yafei Liu, Wai Tuck Soh, Jun ichi Kishikawa, Mika Hirose, Emi E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa …

Cell, 184(13) 3452-3.47E+21, Jun 24, 2021 Peer-reviewed
Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.

Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Emiko Mihara, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura …

Nature communications, 12(1) 3802-3802, Jun 21, 2021 Peer-reviewedLead author
Hepatitis C virus modulates signal peptide peptidase to alter host protein processing

Junki Hirano, Sachiyo Yoshio, Yusuke Sakai, Li Songling, Tatsuya Suzuki, Yumi Itoh, He Zhang, David Virya Chen, Saori Haga, Hiroko Oomori …

Proceedings of the National Academy of Sciences of the United States of America, 118(22), Jun 1, 2021 Peer-reviewed
Deneddylation by SENP8 restricts hepatitis B virus propagation

David Virya Chen, Tatsuya Suzuki, Yumi Itoh, Yusuke Maeda, Junki Hirano, Saori Haga, He Zhang, Daiki Ito, Yoshiharu Matsuura, Toru Okamoto

Microbiology and Immunology, 65(3) 125-135, Mar 1, 2021 Peer-reviewedLead author
High affinity modified ACE2 receptors prevent SARS-CoV-2 infection

Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Yuhei Kirita, Eriko Ohgitani, Osam Mazda, Daisuke Motooka, Shota Nakamura, Yoshiharu Matsuura …

Sep 16, 2020
Generation of human bronchial organoids for SARS-CoV-2 research

Tatsuya Suzuki, Yumi Itoh, Yusuke Sakai, Akatsuki Saito, Daisuke Okuzaki, Daisuke Motooka, Shohei Minami, Takeshi Kobayashi, Takuya Yamamoto, Toru Okamoto …

May 26, 2020 Peer-reviewed
Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein

Makoto Tokunaga, Yoichi Miyamoto, Tatsuya Suzuki, Mayumi Otani, Shinsuke Inuki, Tsuyoshi Esaki, Chioko Nagao, Kenji Mizuguchi, Hiroaki Ohno, Yoshihiro Yoneda …

Virology, 541 41-51, Feb, 2020 Peer-reviewed
In vivo dynamics of reporter flaviviridae viruses

Tomokazu Tamura, Manabu Igarashi, Bazarragchaa Enkhbold, Tatsuya Suzuki, Masatoshi Okamatsu, Chikako Ono, Hiroyuki Mori, Takuma Izumi, Asuka Sato, Yuzy Fauzyah …

Journal of Virology, 93(22), Nov 1, 2019 Peer-reviewed
USP15 participates in hepatitis C virus propagation through regulation of viral RNA translation and lipid droplet formation

Shinji Kusakabe, Tatsuya Suzuki, Yukari Sugiyama, Saori Haga, Kanako Horike, Makoto Tokunaga, Junki Hirano, He Zhang, David Virya Chen, Hanako Ishiga …

Journal of Virology, 93(6), Mar 1, 2019 Peer-reviewed
Infection with flaviviruses requires BCLXL for cell survival

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa …

PLoS Pathogens, 14(9) e1007299, Sep, 2018 Peer-reviewedLead author
Characterization of SPP inhibitors suppressing propagation of HCV and protozoa

Junki Hirano, Toru Okamoto, Yukari Sugiyama, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Takasuke Fukuhara, Miwa Sasai, Takahiro Tougan, Yasue Matsunaga …

Proceedings of the National Academy of Sciences of the United States of America, 114(50) E10782-E10791, Dec 12, 2017 Peer-reviewed

Misc.

[Advances in the reverse genetics system for RNA viruses].

Tatsuya Suzuki, Akatsuki Saito

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 157(2) 134-138, Mar 1, 2022 Peer-reviewed
Regulation of apoptosis during flavivirus infection

Toru Okamoto, Tatsuya Suzuki, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Yoshiharu Matsuura

Viruses, 9(9), Sep 1, 2017 Peer-reviewed

Presentations

Regulation of cellular energy metabolism in Japanese encephalitis virus infected cells

伊東祐美, 土岐弥生, 谷口百優, 鈴木達也, 福崎英一郎, 岡本徹

日本ウイルス学会学術集会プログラム・予稿集(Web), 2021
Selective TLR ligands stimulated pathogenicity of JEV infection in vivo

Yuka Miyata, Tatsuya Suzuki, Toru Okamoto, Yoshiharu Matsuura

Sep, 2017
BCLXL participates in pathogenicity of flavivirus infection

Tatsuya Suzuki, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Takasuke Fukuhara, Toru Okamoto, Yoshiharu Matsuura

Sep, 2017
BCLXL dependent survivals upon infection with Flaviviruses

Tatsuya Suzuki, Toru Okamoto, Takasuke Fukuhara, Yoshiharu Matsuura

Jun, 2017
JMJD5 regulates HBV replication through interaction with HBx

Toru Okamoto, Kazuo Yamashita, Tatsuya Suzuki, Shinji Kusakabe, Junki Hirano, Takasuke Fukuhara, Atsuya Yamashita, Kazunobu Saito, Daisue Okuzaki, Daron M Stanley, Khoji Moriishi, Yoshiharu Matsuura

Apr, 2017
Evaluation of γ-secretase inhibitors for HCV therapy

Junki Hirano, Yukari Sugiyama, Tatsuya Suzuki, Shinji Kusakabe, Takasuke Fukuhara, Toru Okamoto, Yoshiharu Matsuura

Oct, 2016
Single peptide peptidase a target for anti-HCV drug

Toru Okamoto, Junki Hirano, Tatsuya Suzuki, Shinji Kusakabe, Takasuke Fukuhara, Kohji Moriishi, Kazuhiko Koike, Yoshiharu Matsuura

Oct, 2016
Glycine 135 of JMJD5 is involved in the interaction with HBx

Shinji Kusakabe, Takahisa Kouwaki, Yukari Sugiyama, Tatsuya Suzuki, Junki Hirano, Takasuke Fukuhara, Masaya Sugiyama, Masashi Mizokami, Toru Okamoto, Yoshiharu Matsuura

Oct, 2016
Regulation of Bcl-2 family proteins in cells infected with Flaviviruses

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Takasuke Fukuhara, Yoshiharu Matsuura

Nov, 2015
ゲノム編集技術を用いたHCVコアタンパク質の機能解析

岡本徹, 相澤清香, 杉山由加理, 幸脇貴久, 伊藤彩乃, 鈴木達也, 福原崇介, 森石恆司, 小池和彦, 松浦善治

May, 2015 Invited
Processing of Core Protein by Signal Peptide Peptidase Participates in Propagation and Pathogenesis of Hepatitis C Virus

Toru Okamoto, Sayaka Aizawa, Takahisa Kouwaki, Tatsuya Suzuki, Francesc Puig-Basagoiti, Shinya Watanabe, Takasuke Fukuhara, Kohji Moriishi, Kazuhiko Koike, Yoshiharu Matsuura

Sep, 2014

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