論文

2021年7月16日

Concomitant Mitral Regurgitation in Severe Aortic Stenosis - A Report From the CURRENT AS Registry.

Circulation journal : official journal of the Japanese Circulation Society
  • Ryosuke Murai
  • ,
  • Yuichi Kawase
  • ,
  • Tomohiko Taniguchi
  • ,
  • Takeshi Morimoto
  • ,
  • Kazushige Kadota
  • ,
  • Masanobu Ohya
  • ,
  • Takenobu Shimada
  • ,
  • Takeshi Maruo
  • ,
  • Yasushi Fuku
  • ,
  • Tatsuhiko Komiya
  • ,
  • Kenji Ando
  • ,
  • Michiya Hanyu
  • ,
  • Norio Kanamori
  • ,
  • Takeshi Aoyama
  • ,
  • Koichiro Murata
  • ,
  • Tomoya Onodera
  • ,
  • Fumio Yamazaki
  • ,
  • Takeshi Kitai
  • ,
  • Yutaka Furukawa
  • ,
  • Tadaaki Koyama
  • ,
  • Makoto Miyake
  • ,
  • Chisato Izumi
  • ,
  • Yoshihisa Nakagawa
  • ,
  • Kazuo Yamanaka
  • ,
  • Hirokazu Mitsuoka
  • ,
  • Manabu Shirotani
  • ,
  • Masashi Kato
  • ,
  • Shinji Miki
  • ,
  • Hiroyuki Nakajima
  • ,
  • Yutaka Hirano
  • ,
  • Shunichi Miyazaki
  • ,
  • Toshihiko Saga
  • ,
  • Sachiko Sugioka
  • ,
  • Shintaro Matsuda
  • ,
  • Mitsuo Matsuda
  • ,
  • Tatsuya Ogawa
  • ,
  • Kazuya Nagao
  • ,
  • Tsukasa Inada
  • ,
  • Shogo Nakayama
  • ,
  • Hiroshi Mabuchi
  • ,
  • Yasuyo Takeuchi
  • ,
  • Hiroki Sakamoto
  • ,
  • Genichi Sakaguchi
  • ,
  • Keiichiro Yamane
  • ,
  • Hiroshi Eizawa
  • ,
  • Mamoru Toyofuku
  • ,
  • Takashi Tamura
  • ,
  • Atsushi Iwakura
  • ,
  • Mitsuru Ishii
  • ,
  • Masaharu Akao
  • ,
  • Kotaro Shiraga
  • ,
  • Eri Minamino-Muta
  • ,
  • Takao Kato
  • ,
  • Moriaki Inoko
  • ,
  • Koji Ueyama
  • ,
  • Tomoyuki Ikeda
  • ,
  • Yoshihiro Himura
  • ,
  • Akihiro Komasa
  • ,
  • Katsuhisa Ishii
  • ,
  • Kozo Hotta
  • ,
  • Yukihito Sato
  • ,
  • Keiichi Fujiwara
  • ,
  • Yoshihiro Kato
  • ,
  • Ichiro Kouchi
  • ,
  • Yasutaka Inuzuka
  • ,
  • Shigeru Ikeguchi
  • ,
  • Senri Miwa
  • ,
  • Chiyo Maeda
  • ,
  • Eiji Shinoda
  • ,
  • Junichiro Nishizawa
  • ,
  • Toshikazu Jinnai
  • ,
  • Nobuya Higashitani
  • ,
  • Mitsuru Kitano
  • ,
  • Yuko Morikami
  • ,
  • Shouji Kitaguchi
  • ,
  • Kenji Minatoya
  • ,
  • Takeshi Kimura

86
3
開始ページ
427
終了ページ
437
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1253/circj.CJ-21-0054

BACKGROUND: The clinical significance of concomitant mitral regurgitation (MR) has not been well addressed in patients with severe aortic stenosis (AS).Methods and Results:We analyzed 3,815 patients from a retrospective multicenter registry of severe AS in Japan (CURRENT AS registry). We compared the clinical outcomes between patients with moderate/severe MR and with none/mild MR according to the initial treatment strategy (initial aortic valve replacement [AVR] or conservative strategy). The primary outcome measure was a composite of aortic valve-related death or heart failure hospitalization. At baseline, moderate/severe MR was present in 227/1,197 (19%) patients with initial AVR strategy and in 536/2,618 (20%) patients with a conservative strategy. The crude cumulative 5-year incidence of the primary outcome measure was significantly higher in patients with moderate/severe MR than in those with none/mild MR, regardless of the initial treatment strategy (25.2% vs. 14.4%, P<0.001 in the initial AVR strategy, and 63.3% vs. 40.7%, P<0.001 in the conservative strategy). After adjusting confounders, moderate/severe MR was not independently associated with higher risk for the primary outcome measure in the initial AVR strategy (hazard ratio [HR] 1.11, 95% confidence interval [CI] 0.67-1.83, P=0.69), and in the conservative strategy (HR 1.13, 95% CI 0.93-1.37, P=0.22). CONCLUSIONS: Concomitant moderate/severe MR was not independently associated with higher risk for the primary outcome measure regardless of the initial treatment strategy.

リンク情報
DOI
https://doi.org/10.1253/circj.CJ-21-0054
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34275976
ID情報
  • DOI : 10.1253/circj.CJ-21-0054
  • PubMed ID : 34275976

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