論文

査読有り 国際誌
2019年12月

Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.

Journal of pediatric surgery
  • Takayuki Fujii
  • ,
  • Yoichi Chiba
  • ,
  • Haruyuki Nakayama-Imaohji
  • ,
  • Shun Onishi
  • ,
  • Aya Tanaka
  • ,
  • Hiroto Katami
  • ,
  • Tatsuru Kaji
  • ,
  • Satoshi Ieiri
  • ,
  • Takanori Miki
  • ,
  • Masaki Ueno
  • ,
  • Tomomi Kuwahara
  • ,
  • Ryuichi Shimono

54
12
開始ページ
2514
終了ページ
2519
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jpedsurg.2019.08.048

PURPOSE: Short bowel syndrome is associated with intestinal mucosal inflammation and microbial dysbiosis, leading to intractable complications. Partially hydrolyzed guar gum (PHGG) has trophic and anti-inflammatory effects on the intestine. We investigated whether PHGG ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model. METHODS: Sprague Dawley rats were divided into sham operation (Sham), Sham/PHGG, SBR, and SBR/PHGG groups. On day 21, all rats were euthanized. To assess small intestinal mucosal damage, the degeneration rate was morphometrically evaluated and immunohistochemically examined using anti-CD45 antibodies. Analyses of fecal microbiota using 16S rRNA and short-chain fatty acid production were also performed. RESULTS: The mucosal degeneration rate was significantly higher in the SBR group than in the Sham or SBR/PHGG groups. The number of CD45-positive cells was significantly higher in the SBR group than in the Sham, Sham/PHGG, or SBR/PHGG groups. The relative abundance of family Lachnospiraceae was significantly higher in the SBR/PHGG group than in the SBR group. CONCLUSIONS: PHGG administration alleviated small intestinal mucosal damage which could be associated with modulation of the intestinal microbiota.

リンク情報
DOI
https://doi.org/10.1016/j.jpedsurg.2019.08.048
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31515113

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