Takumi CHINEN

Profile Information

Molecular basis promoting centriole triplet microtubule assembly

Takeda Y, Chinen T*, Honda S, Takatori S, Okuda S, Yamamoto S, Fukuyama M, Takeuchi K, Tomita T, Hata S* …

Nature Communications, 15 2216, Mar 22, 2024 Peer-reviewedCorresponding author
Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.

Chinen T¹*, Yamazaki K¹, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D …

Journal of Cell Biology, 220(2), Feb 1, 2021 Peer-reviewedLead authorCorresponding author
NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.

Takumi Chinen, Shohei Yamamoto, Yutaka Takeda, Koki Watanabe, Kanako Kuroki, Kaho Hashimoto, Daisuke Takao, Daiju Kitagawa

The EMBO Journal, 39(2) e102378, Jan 15, 2020 Peer-reviewedLead author
The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.

Takumi Chinen, Peng Liu, Shuya Shioda, Judith Pagel, Berati Cerikan, Tien-Chen Lin, Oliver Gruss, Yoshiki Hayashi, Haruka Takeno, Tomohiro Shima …

Nature Communications, 6 8722-8722, Oct 27, 2015 Peer-reviewedLead author
Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.

Chinen T¹, Kazami S¹, Nagumo Y, Hayakawa I, Ikedo A, Takagi M, Yokosuka A, Imamoto N, Mimaki Y, Kigoshi H …

ACS Chemical Biology, 8(5) 884-9, May 17, 2013 Peer-reviewedLead author

Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes.

Yutaka Takeda, Kanako Kuroki, Takumi Chinen, Daiju Kitagawa

Cell structure and function, 45(1) 57-64, May 23, 2020 Corresponding author
Mechanisms of spindle bipolarity establishment in acentrosomal human cells.

Kaho Hashimoto, Takumi Chinen, Daiju Kitagawa

Molecular & cellular oncology, 7(3) 1743899-1743899, 2020 Corresponding author
20191001

TAKEDA Yutaka, CHINEN Takumi, KITAGAWA Daiju

Farumashia, 55(10) 954-958, 2019

The Yeast Role in Medical Applications

Chinen, Takumi, Hamada, Keisuke, Taguchi, Akihiro, Asami, Yukihiro, Shiomi, Kazuro, Hayashi, Yoshio, Usui, Takeo (Role: Contributor, Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics)

Jan, 2018

ヒト非中心体性細胞における染色体分配機構

知念拓実, 北川大樹

日本遺伝学会大会プログラム・予稿集, Aug 27, 2018 Invited
Mechanisms of the spindle bipolarity establishment in human acentrosomal cells

Takumi CHINEN

Joint Meeting of JSCB 70th & JSDB 51st, Jun, 2018 Invited
γ‐tubulin特異的阻害剤gatastatinを用いた分裂期γ‐tubulin機能の解析

知念拓実, 塩田秀也, PAGEL Judith, SCHIEBEL Elmar, 早川一郎, 木越英夫, 臼井健郎

日本農芸化学会大会講演要旨集(Web), Mar 5, 2016
γチューブリン特異的阻害剤の探索と発見

知念拓実, 塩田秀也, LIU Peng, SCHIEBEL Elmar, 早川一郎, 木越英夫, 臼井健郎

日本農芸化学会大会講演要旨集(Web), Mar 5, 2015

微小管-紡錘体極マトリクスからなるLLPS複合体形成を介した、タキソールの抗がんメカニズムの解明

薬学系研究助成, 武田科学振興財団, 2022 - 2027

知念拓実
染色体数に応じた紡錘体形状の適応メカニズムの解明

基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

知念拓実
分裂期タイマーを介したがん抑制機構の解明

研究助成, 内藤記念科学奨励金, 2022 - 2024

知念拓実
難治性ALLに対する網羅的な創薬標的同定

基礎科学研究助成, 住友財団, 2022 - 2023

知念拓実
血液がん細胞の紡錘体脆弱性の理解と創薬応用

研究奨励金, 上原記念生命科学財団, 2022 - 2023

知念拓実
難治性の急性骨髄性白血病を標的とする抗がんストラテジーの開発

研究助成, 日本新薬株式会社, 2023
Understanding the specific mitotic machinery of blood cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, 2020 - 2021

Chinen Takumi
分裂期紡錘体の二極性を保証する多様な分子基盤の解明

若手研究, 日本学術振興会, 2018 - 2020

知念拓実