Tomoko Doi

Profile Information

Affiliation: Associate Professor, Department of Biophysics, Kyoto University

Degree: Ph.D(Osaka University)

J-GLOBAL ID: 201401058805718877
researchmap Member ID: 7000008401

Research Areas

Life sciences / Functional biochemistry /

Papers

Characterization of Critical Residues in the Extracellular and Transmembrane Domains of the Endothelin Type B Receptor for Propagation of the Endothelin-1 Signal

Tomoko Doi, Kohei Kikuta, Kazutoshi Tani

Biochemistry, 59(18) 1718-1727, May 12, 2020 Peer-reviewed
X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog

Wataru Shihoya, Tomohiro Nishizawa, Keitaro Yamashita, Asuka Inoue, Kunio Hirata, Francois Marie Ngako Kadji, Akiko Okuta, Kazutoshi Tani, Junken Aoki, Yoshinori Fujiyoshi …

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 24(9) 758-+, Sep, 2017 Peer-reviewed
結晶構造から明らかになった、エンドセリン-1によるエンドセリン受容体B型の活性化機構(Crystal structures of the endothelin receptor type B reveal activation mechanism by endothelin-1)

Shihoya Wataru, Nishizawa Tomohiro, Okuta Akiko, Tani Kazutoshi, Fujiyoshi Yoshinori, Nureki Osamu, Doi Tomoko

生物物理, 56(Suppl.1-2) S175-S175, Oct, 2016
Activation Mechanism of Endothelin ETB Receptor by Endothelin-1

Wataru Shihoya, Tomohiro Nishizawa, Akiko Okuta, Kazutoshi Tani, Naoshi Dohmae, Yoshinori Fujiyoshi, Osamu Nureki, Tomoko Doi

Nature, 537(7620) 368, Sep, 2016 Peer-reviewed
Thermostabilization of the Human Endothelin Type B Receptor

Akiko Okuta, Kazutoshi Tani, Shoko Nishimura, Yoshinori Fujiyoshi, Tomoko Doi

JOURNAL OF MOLECULAR BIOLOGY, 428(11) 2265-2274, Jun, 2016 Peer-reviewed
Characterization of physiological phenotypes of dentate gyrus synapses of PDZ1/2 domain-deficient PSD-95-knockin mice

Hitoshi Nagura, Tomoko Doi, Yoshinori Fujiyoshi

EUROPEAN JOURNAL OF NEUROSCIENCE, 43(5) 618-625, Mar, 2016 Peer-reviewed
An intracellular domain with a novel sequence regulates cell surface expression and synaptic clustering of leucine-rich repeat transmembrane proteins in hippocampal neurons

Keiichiro Minatohara, Yasunobu Murata, Yoshinori Fujiyoshi, Tomoko Doi

JOURNAL OF NEUROCHEMISTRY, 134(4) 618-628, Aug, 2015 Peer-reviewed
Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95

Keiichiro Minatohara, Sho-hei Ichikawa, Tatsuya Seki, Yoshinori Fujiyoshi, Tomoko Doi

NEUROSCIENCE LETTERS, 533(1) 44-49, Jan, 2013 Peer-reviewed
Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

Hitoshi Nagura, Yasuyuki Ishikawa, Katsunori Kobayashi, Keizo Takao, Tomo Tanaka, Kouki Nishikawa, Hideki Tamura, Sadao Shiosaka, Hidenori Suzuki, Tsuyoshi Miyakawa …

MOLECULAR BRAIN, 5(1), Dec, 2012 Peer-reviewed
Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95

M Nonaka, T Doi, Y Fujiyoshi, S Takemoto-Kimura, H Bito

JOURNAL OF NEUROSCIENCE, 26(3) 763-774, Jan, 2006 Peer-reviewed
Expression and localization of an exogenous G protein-coupled receptor fused with the rhodopsin C-terminal sequence in the retinal rod cells of knockin mice

T Kodama, H Imai, T Doi, O Chisaka, Y Shichida, Y Fujiyoshi

EXPERIMENTAL EYE RESEARCH, 80(6) 859-869, Jun, 2005 Peer-reviewed
Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor

Y Murata, T Doi, H Taniguchi, Y Fujiyoshi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 327(1) 183-191, Feb, 2005 Peer-reviewed
Characterization and application of monoclonal antibodies against human endothelin B receptor expressed in insect cells

T Yamaguchi, Arimoto-Tahara, I, Y Fujiyoshi, T Doi

BIOTECHNOLOGY LETTERS, 26(4) 293-299, Feb, 2004 Peer-reviewed
Regulated interaction of endothelin B receptor with caveolin-1

T Yamaguchi, Y Murata, Y Fujiyoshi, T Doi

EUROPEAN JOURNAL OF BIOCHEMISTRY, 270(8) 1816-1827, Apr, 2003 Peer-reviewed
Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26 - Implication for key amino acid residues for channel formation and function

A Oshima, T Doi, K Mitsuoka, S Maeda, Y Fujiyoshi

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(3) 1807-1816, Jan, 2003 Peer-reviewed
A new technique to co-localise membrane proteins with Homer/vesl

Y Hiroaki, K Nishikawa, K Mitsuoka, T Tachibana, K Sobue, T Doi, Y Fujiyoshi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 295(3) 756-765, Jul, 2002 Peer-reviewed
Crystal structure of the homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif

K Irie, T Nakatsu, K Mitsuoka, A Miyazawa, K Sobue, Y Hiroaki, T Doi, Y Fujiyoshi, H Kato

JOURNAL OF MOLECULAR BIOLOGY, 318(4) 1117-1126, May, 2002 Peer-reviewed
Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel

F Imamura, S Maeda, T Doi, Y Fujiyoshi

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(5) 3640-3646, Feb, 2002 Peer-reviewed
W276 mutation in the endothelin receptor subtype B impairs G(q) coupling but not G(i) or G(o) coupling

F. Imamura, I. Arimoto, Y. Fujiyoshi, T. Doi

Biochemistry, 39(4) 686-692, 2000 Peer-reviewed
Interactions of endothelin receptor subtypes A and B with G(i), G(o), and G(q) in reconstituted phospholipid vesicles

T Doi, H Sugimoto, N Arimoto, Y Hiroaki, Y Fujiyoshi

BIOCHEMISTRY, 38(10) 3090-3099, Mar, 1999 Peer-reviewed

Misc.

Human Mutations in Endothelin A Receptor provide an insight into structural rearrangement in GPCR

Y. Kurihara, T. Doi, C.T. Gordon, J. Amiel, H. Kurihara

Molecular pharmacology Gordon Research Conference, Mar, 2017
GPCRエンドセリンA受容体変異マウスによるヒト希少疾患の病態解明と予後の推測

栗原由紀子, 北沢太郎, 小谷理沙, C.T. Gordon, 河村悠美子, 益田将, 土井知子, J. Amiel, 栗原裕基

第39回分子生物学会, Dec, 2016
エンドセリン-1によるエンドセリンＢ受容体の活性化機構

西澤知宏, 志甫谷渉, 奥田明子, 谷一寿, 藤吉好則, 土井知子

第39回分子生物学会, Nov, 2016
エンドセリン受容体B型によるエンドセリン認識の構造基盤

志甫谷渉, 西澤知宏, 奥田明子, 谷一寿, 藤吉好則, 濡木理, 土井知子

第39回分子生物学会, Nov, 2016
結晶構造から明らかになった、エンドセリン-1によるエンドセリン受容体B型の活性化機構

志甫谷渉, 西澤知宏, 奥田明子, 谷一寿, 藤吉好則, 濡木理, 土井知子

第54回日本生物物理学会（茨城）, Nov, 2016
臨床薬ボセンタンの結合したエンドセリン受容体B型の結晶構造

志甫谷渉, 西澤知宏, 奥田明子, 谷一寿, 藤吉好則, 濡木理, 土井知子

第11回日本ケミカルバイオロジー学会京都テルサホール, Jun, 2016
複数の結晶構造から明らかになった、エンドセリン受容体B型のリガンド認識機構

志甫谷渉, 西澤知宏, 奥田明子, 谷一寿, 藤吉好則, 濡木理, 土井知子

第17回日本蛋白質学会, Jun, 2016
Crystal structures of the endothelin type B receptor

Wataru Shihoya, Tomohiro Nishizawa, Akiko Okuta, Kazutoshi Tani, Yoshinori Fujiyoshi, Osamu Nureki, Tomoko Doi

Oct, 2015
神経接着分子、LRRTM2はその細胞内領域によって細胞表面への輸送、シナプス集積を調節する。

湊原圭一郎, 藤吉好則, 土井知子

第36回日本神経科学大会(京都国際会議場）, Jun, 2013 Peer-reviewed
Roles of the PDZ1/2 domain ligand-binding of PSD-95 in hippocampal synaptic transmission and plasticity.

Hitoshi Nagura, Yasuyuki Ishikawa, Katsunori Kobayashi, Hideki Tamura, Sadao Shiosaka, Hidenori Suzuki, Yoshinori Fujiyoshi, Tomoko Doi

第35回日本神経科学会（名古屋国際会議場）, Sep 20, 2012 Peer-reviewed
Preferable binding of a novel synaptic adhesion molecule, LRRTM2 with SAP102.

湊原圭一郎, 藤吉好則, 土井知子

日本神経科学大会, Sep 3, 2010 Peer-reviewed
Characterization of thermostable hETBR mutants

OKUTA Akiko, NISHIMURA Shoko, FUJIYOSHI Yoshinori, FUJIYOSHI Yoshinori, DOI Tomoko

生化学, ROMBUNNO.4P-0294, 2010 Peer-reviewed
The ligand-binding of PDZ domains play different roles in the synaptic clustering of PSD-95 and SAP102.

市川昌平, 関達也, 藤吉好則, 土井知子

分子生物学会, Dec 17, 2009 Peer-reviewed
Characterization of hETBR expressed in E.coli for isolation of thermo-stable mutants.

奥田明子, 西村章子, 藤吉好則, 土井知子

日本生化学会, Oct 21, 2009 Peer-reviewed
mGluRの集積機構を利用した2次元結晶化への試み

広明洋子, 西川幸希, 入江克雅, 土井知子, 光岡薫, 立花太郎, 祖父江憲治, 藤吉好則

生化学, 72(8), 2000
Isolation of ET_BR・Gi complex and its reconstitution into phospholipid vesicles.

Yamaguchi T., Fujiyoshi Y., Arimoto I., Doi T.

Biophysics, 38(2) S48, Sep 7, 1998
CRYSTAL-STRUCTURE OF T4 ENDONUCLEASE-V - AN EXCISION REPAIR ENZYME SPECIFIC FOR A PYRIMIDINE-DIMER

K MORIKAWA, M ARIYOSHI, K KATAYANAGI, T DOI, M IKEHARA, E OHTSUKA

PROTEIN ENGINEERING, 6 40-40, 1993

Books and Other Publications

Structure and activation of endothelin ETB receptor by endothelin [Video file].

Tomoko Doi

Henry Stewart Talks,, Sep, 2019
Early activation mechanism of ETB receptor by ET-1 binding

Tomoko Doi, Kazutoshi Tani (Role: Joint author)

Aug, 2017
シナプス局在から見えるPSD-95ファミリーの機能多様性

土井知子

医学書院, Oct 15, 2010

Presentations

Endothelin Receptor-Ligand binding and conformational changes

Tomoko Doi

International GPCR symposium, Jun 30, 2018
Structure and function of endothelin receptor

Tomoko Doi

The 2nd Japanese Pulmonary Circulation and Pulmonary Hypertension Society, Jun 2, 2017 Invited
エンドセリン受容体のリガンド認識機構の研究

土井知子

薬学会第137年会, Mar 26, 2017

Research Projects

血管収縮を調節するペプチドホルモン受容体の活性化機構の解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

土井知子
Studies of prerequisites for ETB agonists to accelerate anti-cancer therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

Doi Tomoko
Challenge for heterodimer formation of endothelin receptors in nanodiscs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Doi Tomoko
Regulation of synaptic transmission by the scaffolding protein PSD-95

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

DOI Tomoko, ISHIKAWA Yasuyuki, TAMURA Hideki, SHIOSAKA Sadao, TAKAO Keizo, MIYAKAWA Tsuyoshi, FUJIYOSHI Yoshinori

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