論文

査読有り
2016年7月1日

Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish

Journal of Pharmacological Sciences
  • Yuichi Saito
  • ,
  • Kazuhiro Tsuruma
  • ,
  • Masamitsu Shimazawa
  • ,
  • Yuhei Nishimura
  • ,
  • Toshio Tanaka
  • ,
  • Hideaki Hara

131
3
開始ページ
215
終了ページ
218
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jphs.2016.05.009
出版者・発行元
Japanese Pharmacological Society

Age-related macular degeneration (AMD) is a major cause of irreversible loss of central vision in the elderly. Zebrafish is an attractive animal model in some respects, lower cost, smaller housing facilities and easier genetic manipulation compared to rodents. The present study aimed to establish a drug evaluation method against light irradiation, as a dry AMD disease model, using adult pigmented zebrafish. Intravitreal administration of an antioxidant, N-acetylcysteine, protected against light-induced retinal degeneration in a concentration-dependent manner. We established a new drug evaluation model against light-induced retinal degeneration that can provide new knowledge about dry AMD pathology and therapy.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.jphs.2016.05.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27430989
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000381094400008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jphs.2016.05.009
  • ISSN : 1347-8648
  • ISSN : 1347-8613
  • eISSN : 1347-8648
  • PubMed ID : 27430989
  • SCOPUS ID : 84990062778
  • Web of Science ID : WOS:000381094400008

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