2019年8月29日
Distinct methylation levels of mature microRNAs in gastrointestinal cancers.
Nature communications
- 巻
- 10
- 号
- 1
- 開始ページ
- 3888
- 終了ページ
- 3888
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-019-11826-1
The biological significance of micro (mi)RNAs has traditionally been evaluated according to their RNA expression levels based on the assumption that miRNAs recognize and regulate their targets in an unvarying fashion. Here we show that a fraction of mature miRNAs including miR-17-5p, -21-5p, and -200c-3p and let-7a-5p harbor methyl marks that potentially alter their stability and target recognition. Importantly, methylation of these miRNAs was significantly increased in cancer tissues as compared to paired normal tissues. Furthermore, miR-17-5p methylation level in serum samples distinguished early pancreatic cancer patients from healthy controls with extremely high sensitivity and specificity. These findings provide a basis for diagnostic strategies for early-stage cancer and add a dimension to our understanding of miRNA biology.
- リンク情報
- ID情報
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- DOI : 10.1038/s41467-019-11826-1
- PubMed ID : 31467274
- PubMed Central 記事ID : PMC6715669