2021年5月7日
Catalytic Enantioselective Allylation of Acetylenic Aldehydes by Chiral Phosphoric Acid/Transition Metal Cooperative Catalysis: Formal Synthesis of Fostriecin
Organic Letters
- ,
- 巻
- 23
- 号
- 9
- 開始ページ
- 3767
- 終了ページ
- 3771
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.1c01166
- 出版者・発行元
- American Chemical Society ({ACS})
An enantioselective allylation of silyl-substituted acetylenic aldehydes by chiral phosphoric acid (CPA)/transition metal cooperative catalysis was developed. Enantioenriched homoallylic propargyl alcohols were obtained in good yields with excellent enantioselectivities (>99% ee) under mild conditions. Moreover, the shortest formal synthesis of fostriecin was achieved by the present enantioselective allylation protocol as the key step. The known intermediate of fostriecin reported by McDonald and co-worker was synthesized in only nine steps in 39% total yield.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.orglett.1c01166
- ISSN : 1523-7060
- eISSN : 1523-7052
- ORCIDのPut Code : 92704333
- PubMed ID : 33890790
- SCOPUS ID : 85105905000