Tsuyoshi Esaki

Profile Information

Affiliation: Associate Professor, Faculty of Data Science, Shiga University

Degree: 博士（理学）(大阪大学)

Researcher number: 20717805
J-GLOBAL ID: 201801019798579291
researchmap Member ID: B000296883

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Faculty of Data Science, Shiga University
Apr, 2020 - Present

Faculty of Culture and Information Science, Doshisha University
Apr, 2022 - Mar, 2023

Shiga University
Apr, 2019 - Mar, 2023

客員研究員, AI健康・医薬研究センター, 医薬基盤・健康・栄養研究所
Apr, 2020 - Mar, 2022

Center for Data Science Education and Research, Shiga University
Jul, 2018 - Mar, 2020

非常勤講師, 東京医科歯科大学
Apr, 2019 - Mar, 2020

Center for Data Science Education and Research, Shiga University
Apr, 2016 - Mar, 2019

特任研究員, バイオインフォマティクスプロジェクト, 医薬基盤・健康・栄養研究所
Apr, 2012 - Mar, 2016

テクニカルスタッフ, 生命システム研究センター, 理化学研究所
Apr, 2010 - Mar, 2012

職員（事務系）, 医歯薬学総合研究科等運営支援グループ, 広島大学

Education

Sep, 2012 - Sep, 2015

Osaka University
Apr, 2008 - Mar, 2010

The Graduate School of Natural Science and Technology, Okayama University
Apr, 2004 - Mar, 2008

Faculty of Science, Okayama University

Papers

DruMAP: A Novel Drug Metabolism and Pharmacokinetics Analysis Platform

Hitoshi Kawashima, Reiko Watanabe, Tsuyoshi Esaki, Masataka Kuroda, Chioko Nagao, Yayoi Natsume-Kitatani, Rikiya Ohashi, Hiroshi Komura, Kenji Mizuguchi

Journal of Medicinal Chemistry, Jul 14, 2023
Utilizing public and private sector data to build better machine learning models for the prediction of pharmacokinetic parameters.

Masataka Kuroda, Reiko Watanabe, Tsuyoshi Esaki, Hitoshi Kawashima, Rikiya Ohashi, Tomohiro Sato, Teruki Honma, Hiroshi Komura, Kenji Mizuguchi

Drug discovery today, 103339-103339, Aug 13, 2022 Peer-reviewed
Tracking metabolites at single-cell resolution reveals metabolic dynamics during plant mitosis.

Emiko Okubo-Kurihara, Ahmed Ali, Mika Hiramoto, Yukio Kurihara, Yasmine Abouleila, Eman Muhammad Abdelazem, Takayuki Kawai, Yuko Makita, Mika Kawashima, Tsuyoshi Esaki …

Plant physiology, 189(2) 459-464, Mar 18, 2022 Peer-reviewed
Appropriate Evaluation Measurements for Regression Models

Tsuyoshi Esaki

CBI Journal, 21 59-69, Sep, 2021 Peer-reviewedLead authorCorresponding author
Development of an in silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells Towards the Prediction of Brain Penetration

Reiko Watanabe, Tsuyoshi Esaki, Rikiya Ohashi, Masataka Kuroda, Hitoshi Kawashima, Hiroshi Komura, Yayoi Natsume-Kitatani, Kenji Mizuguchi

Journal of Medicinal Chemistry, Feb 23, 2021 Peer-reviewed
Estimation of relationships between gene expression and chemical substructures: Adapting canonical correlation analysis for small sample data by gathered features using consensus clustering

Tsuyoshi Esaki, Takaaki Horinouchi, Yayoi Natsume-Kitatani, Yosui Nojima, Iwao Sakane, Hidetoshi Matsui

CBI Journal, 20 58-61, Sep, 2020 Peer-reviewedLead authorCorresponding author
Open Innovation Platform using Cloud-based Applications and Collaborative Space: A Case Study of Solubility Prediction Model Development

Tsuyoshi Esaki, Keio Kumazawa, Kazutoshi Takahashi, Reiko Watanabe, Tomohide Masuda, Hirofumi Watanabe, Yugo Shimizu, Akitoshi Okada, Seisuke Takimoto, Shimada …

CBI Journal, 20 5-18, Apr, 2020 Peer-reviewedLead authorCorresponding author
Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein.

Tokunaga M, Miyamoto Y, Suzuki T, Otani M, Inuki S, Esaki T, Nagao C, Mizuguchi K, Ohno H, Yoneda Y …

Virology, 541 41-51, Feb, 2020 Peer-reviewed
Development of an in silico prediction system of human renal excretion and clearance from chemical structure information incorporating fraction unbound in plasma as a descriptor

Watanabe R, Ohashi R, Esaki T, Kawashima H, Natsume-Kitatani Y, Nagao C, Mizuguchi K

Scientific Reports, 9(1) 18782-18782, Dec, 2019 Peer-reviewed
創薬支援のデータサイエンス～薬物動態データから更なる価値の創造をめざして～

江崎剛史, 池田和由

創薬のひろば, 11(秋) 16-19, Oct, 2019 Peer-reviewedInvitedLead author
Computational Model To Predict the Fraction of Unbound Drug in the Brain

Tsuyoshi Esaki, Rikiya Ohashi, Reiko Watanabe, Yayoi Natsume-Kitatani, Hitoshi Kawashima, Chioko Nagao, Kenji Mizuguchi

Journal of Chemical Information and Modeling, 59(7) 3251-3261, Jul, 2019 Peer-reviewedLead authorCorresponding author
Constructing an in silico three-class predictor of human intestinal absorption with Caco-2 permeability and dried-DMSO solubility

Tsuyoshi Esaki, Rikiya Ohashi, Reiko Watanabe, Yayoi Natsume-Kitatani, Hitoshi Kawashima, Chioko Nagao, Hiroshi Komura, Kenji Mizuguchi

Journal of Pharmaceutical Sciences, 108(11) 3630-3639, Jul, 2019 Peer-reviewedLead authorCorresponding author
Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein

Rikiya Ohashi, Reiko Watanabe, Tsuyoshi Esaki, Tomomi Taniguchi, Nao Torimoto-Katori, Tomoko Watanabe, Yuko Ogasawara, Tsuyoshi Takahashi, Mikiko Tsukimoto, Kenji Mizuguchi

Molecular Pharmaceutics, 16(5) 1851-1863, Apr, 2019 Peer-reviewed
Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance

Tsuyoshi Esaki, Reiko Watanabe, Hitoshi Kawashima, Rikiya Ohashi, Yayoi Natsume‐Kitatani, Chioko Nagao, Kenji Mizuguchi

Molecular Informatics, 38(1-2) 1800086, Jan, 2019 Peer-reviewedLead authorCorresponding author
Predicting Fraction Unbound in Human Plasma from Chemical Structure: Improved Accuracy in the Low Value Ranges

Reiko Watanabe, Tsuyoshi Esaki, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Chioko Nagao, Rikiya Ohashi, Kenji Mizuguchi

Molecular Pharmaceutics, 15(11) 5302-5311, Sep, 2018 Peer-reviewed
Dual roles of glutathione in ecdysone biosynthesis and antioxidant function during larval development in Drosophila

Sora Enya, Chikana Yamamoto, Hajime Mizuno, Tsuyoshi Esaki, Hsin-Kuang Lin, Masatoshi Iga, Kana Morohashi, Yota Hirano, Hiroshi Kataoka, Tsutomu Masujima …

Genetics, 207(4) 1519-1532, Dec 1, 2017 Peer-reviewed
創薬支援インフォマティクスシステム構築プロジェクト:薬物動態、毒性の統合解析プラットフォーム

江崎剛史, 渡邉怜子, 川島和, 夏目やよい, 水口賢司

薬剤学, 77(4) 211-215, Jul, 2017 Peer-reviewedInvitedLead author
Amiodarone intercellular distribution using live single cell mass spectrometry

Kenji Yahata, Shigemichi Morita, Jasminder Sahi, Tsuyoshi Esaki, Hajime Mizuno, Tsutomu Masujima

Drug Metabolism and Pharmacokinetics, 32(1) S44-S44, Jan, 2017 Peer-reviewed
Direct evidence of specific localization of sesquiterpenes and marchantin A in oil body cells of Marchantia polymorpha L.

M. Tanaka, T. Esaki, H. Kenmoku, T. Koeduka, Y. Kiyoyama, T. Masujima, Y. Asakawa, K. Matsui

Phytochemistry, 130 77-84, Oct, 2016 Peer-reviewed
１細胞質量分析を用いたミトコンドリア単体でのダイレクト代謝解析

江崎剛史

大阪大学【学位論文】, Mar, 2016 Peer-reviewed

Books and Other Publications

大学生のためのデータサイエンス（III）問題解決編 -事例で体験する価値創造のプロセス- オフィシャルスタディノート

河本薫, 田中琢真, 岡本哲弥, 江崎剛史, 今井貴志, 李鍾賛, 市川治, 和泉志津恵, 西出亮, 竹村彰通 (Role: Joint author)

日本統計協会, Nov 26, 2020
人と共生するAI革命～活用事例からみる生活・産業・社会の未来展望～

江崎剛史, 渡邉怜子, 夏目やよい, 伊藤眞里, 長尾知生子, 川島和, 水口賢司 (Role: Contributor, AI活用による薬物動態予測システムの開発)

株式会社エヌ・ティ・ティー・エス, Jun, 2019
Encyclopedia of Bioinformatics and Computational Biology

Lokesh P. Tripathi, Tsuyoshi Esaki, Mari N. Itoh, Yi An Chen, Kenji Mizuguchi (Role: Contributor, Integrative analysis of Multi-omics data.)

Elsevier, 2019
[CSJカレントレビュー 23] 先端計測-研究を支える機器開発

伊達沙智子, 江崎剛史, 升島努 (Role: Joint author, PartⅡ 2章: 1細胞質量分析法)

化学同人社, Aug 25, 2016