2010年6月
Fluorinated Polymer Nanoparticles as a Novel F-19 MRI Contrast Agent Prepared by Dendrimer-Initiated Living Radical Polymerization
MACROMOLECULAR CHEMISTRY AND PHYSICS
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- 巻
- 211
- 号
- 12
- 開始ページ
- 1369
- 終了ページ
- 1376
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/macp.200900672
- 出版者・発行元
- WILEY-BLACKWELL
Novel fluorinated polymer nanoparticles (PNPs) for F-19 MRI were prepared by living radical polymerization initiated by a dendrimer. The dendritic macroinitiator with Br substituents was synthesized from hydroxy-group-terminated G2 polyamidoamine dendrimers. The arborescent fluorinated polymers of 2,2,3,3-tetrafluoropropyl methacrylate and 2,2,2-trifluoroethyl methacrylate were characterized in molecular weight, the number of arms, the degree of polymerization per arm, and the diameter as a whole. The PNP diameter was precisely controlled by the molecular weight in the range of 3-25 nm. In addition, the fluorinated PNP gave a narrow resonance by F-19 NMR spectroscopy. These results indicate that the fluorinated PNP can be used as a new type of F-19 MRI agent.
- リンク情報
- ID情報
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- DOI : 10.1002/macp.200900672
- ISSN : 1022-1352
- J-Global ID : 201002268823860957
- Web of Science ID : WOS:000279456200009