2011年8月
Construction of a F-19-lectin biosensor for glycoprotein imaging by using affinity-guided DMAP chemistry
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- 巻
- 21
- 号
- 15
- 開始ページ
- 4393
- 終了ページ
- 4396
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.bmcl.2011.06.038
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
In this study, assisted by affinity-guided DMAP strategy, we developed a novel F-19-modified lectin as a biosensor for specific detection and imaging of glycoproteins. Exploited the large chemical shift anisotropy property of F-19 nuclei, glycoproteins detected by our F-19-biosensor are signatured by broadened peaks in F-19 NMR, hence enabled the distinction between glycoproteins and small molecule saccharides. Such signal on/off switching was also applied to glycoprotein imaging by F-19 MRI. (C) 2011 Elsevier Ltd. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bmcl.2011.06.038
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201102208769797998
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21737264
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000292729900003&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bmcl.2011.06.038
- ISSN : 0960-894X
- eISSN : 1464-3405
- J-Global ID : 201102208769797998
- PubMed ID : 21737264
- Web of Science ID : WOS:000292729900003