2018年11月15日
Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling
Cell Chemical Biology
- 巻
- 25
- 号
- 11
- 開始ページ
- 1403
- 終了ページ
- 1413.e4
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.chembiol.2018.08.007
- 出版者・発行元
- CELL PRESS
Reactive persulfides such as cysteine persulfide and glutathione persulfide are produced by bacteria including Salmonella during sulfur metabolism. The biological significance of bacterial reactive persulfides in host-pathogen interactions still warrants investigation. We found that reactive persulfides produced by Salmonella Typhimurium LT2 regulate macrophage autophagy via metabolizing 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP), an electrophilic product of reactive oxygen species and nitric oxide signaling. 8-Nitro-cGMP signaling was required for efficient autophagy-mediated clearance of Salmonella from infected macrophages. In the infected cells, 8-nitro-cGMP caused cGMP adduct formation (S-guanylation) of bacterial surface proteins, which triggered recruitment of autophagy-related proteins p62 and LC3-II to the intracellular bacteria. We also found that Salmonella-produced reactive persulfides downregulated this autophagy by decreasing cellular 8-nitro-cGMP content, thereby inhibiting electrophilic signaling. These data reveal a pathogenic role of bacteria-derived reactive persulfides via suppression of anti-bacterial autophagy. Khan et al. found that reactive persulfides produced by Salmonella inhibit autophagy-mediated bacterial clearance by regulating electrophilic signaling. These data reveal a pathogenic role of bacteria-derived reactive persulfides via suppression of anti-bacterial autophagy.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.chembiol.2018.08.007
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30197193
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000450370800011&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85056565193&partnerID=MN8TOARS 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85056565193&origin=inward
- ID情報
-
- DOI : 10.1016/j.chembiol.2018.08.007
- ISSN : 2451-9456
- eISSN : 2451-9448
- ORCIDのPut Code : 63850656
- PubMed ID : 30197193
- SCOPUS ID : 85056565193
- Web of Science ID : WOS:000450370800011