論文

査読有り 国際誌
2020年4月3日

Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.

Developmental dynamics : an official publication of the American Association of Anatomists
  • Masanori Takahashi
  • ,
  • Keiko Ikeda
  • ,
  • Masaki Ohmuraya
  • ,
  • Yoshiko Nakagawa
  • ,
  • Tetsushi Sakuma
  • ,
  • Takashi Yamamoto
  • ,
  • Kiyoshi Kawakami

249
9
開始ページ
1098
終了ページ
1116
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/dvdy.174

BACKGROUND: The structure of the mouse incisor is characterized by its asymmetric accumulation of enamel matrix proteins on the labial side. The asymmetric structure originates from the patterning of the epithelial incisor placode through the interaction with dental mesenchymal cells. However, the molecular basis for the asymmetric patterning of the incisor germ is largely unknown. RESULTS: A homeobox transcription factor SIX1 was shown to be produced in the mandibular mesenchyme, and its localization patterns changed dynamically during lower incisor development. Six1-/- mice exhibited smaller lower incisor primordia than wild-type mice. Furthermore, Six1-/- mice showed enamel matrix production on both the lingual and labial sides and disturbed odontoblast maturation. In the earlier stages of development, the formation of signaling centers, the initiation knot and the enamel knot, which are essential for the morphogenesis of tooth germs, were impaired in Six1-/- embryos. Notably, Wnt signaling activity, which shows an anterior-posterior gradient, and the expression patterns of genes involved in incisor formation were altered in the mesenchyme in Six1-/- embryos. CONCLUSION: Our results indicate that Six1 is required for signaling center formation in lower incisor germs and the labial-lingual asymmetry of the lower incisors by regulating the anterior-posterior patterning of the mandibular mesenchyme. This article is protected by copyright. All rights reserved.

リンク情報
DOI
https://doi.org/10.1002/dvdy.174
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32243674
ID情報
  • DOI : 10.1002/dvdy.174
  • PubMed ID : 32243674

エクスポート
BibTeX RIS