2008年10月
Frequency of nocturnal sudden death in patients with multiple system atrophy
JOURNAL OF NEUROLOGY
- ,
- ,
- ,
- ,
- ,
- 巻
- 255
- 号
- 10
- 開始ページ
- 1483
- 終了ページ
- 1485
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00415-008-0941-4
- 出版者・発行元
- DR DIETRICH STEINKOPFF VERLAG
Sudden death has been reported in patients with multiple system atrophy (MSA), although the frequency of this event has not been well delineated. We investigated the frequency and potential causes of sudden death in patients with MSA. During the 5-year observation period, 10 of 45 patients with probable MSA died. The causes of death included sudden death of unknown etiology (seven patients), aspiration pneumonia (one patient), asphyxia after vomiting (one patient), and lung cancer (one patient). The mean survival time of patients with sudden death was 63.0 +/- 24.7 months (range, 39-116 months). Among seven patients who experienced sudden death, six were found to have died during sleep. Among these patients, two had been treated with tracheostomy and three with continuous positive airway pressure (CPAP) or noninvasive positive pressure ventilation (NPPV) during sleep, suggesting that these treatments do not always prevent sudden death in patients with MSA. Nocturnal sudden death should be recognized as the most common mechanism of death in patients with MSA.
- リンク情報
- ID情報
-
- DOI : 10.1007/s00415-008-0941-4
- ISSN : 0340-5354
- Web of Science ID : WOS:000260877600005