藤澤貴央 (Fujisawa Takao) - マイポータル

基本情報

所属: 東京大学大学院薬学系研究科細胞情報学教室助教

J-GLOBAL ID: 201101065324922882
researchmap会員ID: B000004908

東京大学大学院薬学系研究科博士課程

研究キーワード

包括脳ネットワーク

研究分野

経歴

論文

HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding.

Hiroki Ryuno, Yusuke Hanafusa, Takao Fujisawa, Motoyuki Ogawa, Hiroki Adachi, Isao Naguro, Hidenori Ichijo

Communications biology 7(1) 1290-1290 2024年10月9日
Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.

Haruka Matsui, Takayuki Iriyama, Seisuke Sayama, Naoko Inaoka, Kensuke Suzuki, Midori Yoshikawa, Mari Ichinose, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu …

Placenta 115 60-69 2021年11月
Apoptosis signal-regulating kinase 1 (ASK1) as a therapeutic target for neurological diseases.

Satoshi Takenaka, Takao Fujisawa, Hidenori Ichijo

Expert opinion on therapeutic targets 24(11) 1061-1064 2020年11月
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.

Sho Sugawara, Yusuke Kanamaru, Shiori Sekine, Lila Maekawa, Akinori Takahashi, Tadashi Yamamoto, Kengo Watanabe, Takao Fujisawa, Kazuki Hattori, Hidenori Ichijo

The Journal of biological chemistry 295(17) 5588-5601 2020年4月24日
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.

Sho Sugawara, Yusuke Kanamaru, Shiori Sekine, Lila Maekawa, Akinori Takahashi, Tadashi Yamamoto, Kengo Watanabe, Takao Fujisawa, Kazuki Hattori, Hidenori Ichijo

The Journal of biological chemistry 295(17) 5588-5601 2020年4月24日
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase.

Kengo Homma, Hiromitsu Takahashi, Naomi Tsuburaya, Isao Naguro, Takao Fujisawa, Hidenori Ichijo

The Journal of biological chemistry 295(10) 3148-3158 2020年3月6日
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

Jean-Philippe Lambert, Sarah Picaud, Takao Fujisawa, Huayun Hou, Pavel Savitsky, Liis Uusküla-Reimand, Gagan D Gupta, Hala Abdouni, Zhen-Yuan Lin, Monika Tucholska …

Molecular cell 73(3) 621-638 2019年2月7日
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-Ichi Ikeda, Naoki Umezawa …

Nature communications 9(1) 2668-2668 2018年7月10日
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

Keiko Imamura, Yuishin Izumi, Akira Watanabe, Kayoko Tsukita, Knut Woltjen, Takuya Yamamoto, Akitsu Hotta, Takayuki Kondo, Shiho Kitaoka, Akira Ohta …

Science translational medicine 9(391) 2017年5月24日
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.

Takao Fujisawa, Panagis Filippakopoulos

Nature reviews. Molecular cell biology 18(4) 246-262 2017年4月
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Pavel Savitsky, Tobias Krojer, Takao Fujisawa, Jean-Philippe Lambert, Sarah Picaud, Chen-Yi Wang, Erin K Shanle, Krzysztof Krajewski, Hans Friedrichsen, Alexander Kanapin …

Cell reports 17(10) 2724-2737 2016年12月6日
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Sarah Picaud, Katharina Leonards, Jean-Philippe Lambert, Oliver Dovey, Christopher Wells, Oleg Fedorov, Octovia Monteiro, Takao Fujisawa, Chen-Yi Wang, Hannah Lingard …

Science advances 2(10) e1600760 2016年10月
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

Takao Fujisawa, Motoo Takahashi, Yuka Tsukamoto, Namiko Yamaguchi, Masayoshi Nakoji, Megumi Endo, Hiroshi Kodaira, Yuki Hayashi, Hideki Nishitoh, Isao Naguro …

Human molecular genetics 25(2) 245-53 2016年1月15日
A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

Takao Fujisawa, Namiko Yamaguchi, Hisae Kadowaki, Yuka Tsukamoto, Naomi Tsuburaya, Atsushi Tsubota, Hiromitsu Takahashi, Isao Naguro, Yuji Takahashi, Jun Goto …

Neurobiology of disease 82 478-486 2015年10月
[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].

Takao Fujisawa, Hidenori Ichijo

Nihon rinsho. Japanese journal of clinical medicine 72(5) 957-65 2014年5月
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

Kengo Homma, Takao Fujisawa, Naomi Tsuburaya, Namiko Yamaguchi, Hisae Kadowaki, Kohsuke Takeda, Hideki Nishitoh, Atsushi Matsuzawa, Isao Naguro, Hidenori Ichijo

Molecular cell 52(1) 75-86 2013年10月10日査読有り
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Takao Fujisawa, Kengo Homma, Namiko Yamaguchi, Hisae Kadowaki, Naomi Tsuburaya, Isao Naguro, Atsushi Matsuzawa, Kohsuke Takeda, Yuji Takahashi, Jun Goto …

Annals of neurology 72(5) 739-49 2012年11月
ASK family proteins in stress response and disease.

Takao Fujisawa, Kohsuke Takeda, Hidenori Ichijo

Molecular biotechnology 37(1) 13-8 2007年9月査読有り

所属学協会

日本バイオインフォマティクス学会

共同研究・競争的資金等の研究課題

ストレスシグナルの動的制御機構解明による創薬基盤の確立

日本学術振興会科学研究費助成事業基盤研究(S) 2013年5月 - 2018年3月

一條秀憲, 名黒功, 藤澤貴央, 関根史織
ROS-ASK1-p38経路に関わる因子の網羅的スクリーニング

日本学術振興会科学研究費助成事業特別研究員奨励費 2008年 - 2010年

藤澤貴央

藤澤貴央

基本情報

研究キーワード

研究分野

経歴

論文

所属学協会

共同研究・競争的資金等の研究課題

メニュー

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