2005年7月
Chronic food restriction enhances memory in mice - analysis with matched drive levels
NEUROREPORT
- ,
- 巻
- 16
- 号
- 10
- 開始ページ
- 1129
- 終了ページ
- 1133
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/00001756-200507130-00019
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
We compared the effects of chronic and acute food deprivation on learning and memory using a dry-type water maze, active avoidance and passive avoidance in C57BL/6L mice. The drive level of the animals - under acute and chronic food deprivation - was matched by a progressive ratio schedule. Both deprivations led to a high degree of activity in the animals; however, the animals on an acute dietary restriction did not exhibit a significantly better performance than those on ad libitum feeding, while those on a chronic food deprivation exhibited memory enhancement. These effects were subtle and were found at a later stage of learning. These findings suggest that chronic food restriction induces memory consolidation or resistance to memory reduction in addition to increased activity.
- リンク情報
- ID情報
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- DOI : 10.1097/00001756-200507130-00019
- ISSN : 0959-4965
- Web of Science ID : WOS:000230772100019