論文

2018年5月

Development of a new surgical sheet containing both silk fibroin and thermoplastic polyurethane for cardiovascular surgery.

Surgery today
  • Ryo Shimada
  • ,
  • Hayato Konishi
  • ,
  • Hideki Ozawa
  • ,
  • Takahiro Katsumata
  • ,
  • Ryou Tanaka
  • ,
  • Yasumoto Nakazawa
  • ,
  • Shintaro Nemoto

48
5
開始ページ
486
終了ページ
494
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00595-017-1615-6

PURPOSE: The surgical sheets that are currently used for congenital cardiovascular surgery have several drawbacks, including material deterioration, calcification, and pseudo-intimal proliferation resulting in hemodynamic disturbance. The aim of this study was to evaluate a newly developed sheet made from a combination of silk fibroin (SF) and a synthetic polymer, thermoplastic polyurethane (TPU), for surgical use. METHODS: The hybrid SF/TPU sheet was a non-woven fabric with nanofibers that was made using the electrospinning method. The mechanical properties of the SF/TPU sheet were characterized. To determine its biocompatibility, part of the wall of the canine descending aorta was replaced with a SF/TPU sheet as a patch. The patches were removed after 3 months and a histological examination was performed. RESULTS: The flexibility, water permeability, and suture retention strength of the SF/TPU sheet were excellent and equivalent to those of existing sheets. The SF/TPU sheet had excellent handling properties and fit well into the vascular wall without needle hole bleeding. The histological examination revealed that the intimal tissue was restored well over the intraluminal surface of the explanted SF/TPU sheet, the absence of calcium deposition, and minimal inflammatory reaction, without signs of degradation. CONCLUSION: The SF/TPU sheet had excellent mechanical properties and tissue biocompatibility. These favorable features and possible biodegradability of the SF portion warrant a long-term follow-up study.

リンク情報
DOI
https://doi.org/10.1007/s00595-017-1615-6
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29256145
ID情報
  • DOI : 10.1007/s00595-017-1615-6
  • PubMed ID : 29256145

エクスポート
BibTeX RIS