2022年12月16日
Preparation of N‐2‐Nitrophenylsulfenyl Imino Peptides and Their Catalyst‐Controlled Diastereoselective Indolylation
Chemistry – A European Journal
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- ,
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- 巻
- 29
- 号
- 8
- 開始ページ
- e202203120
- 終了ページ
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.202203120
- 出版者・発行元
- Wiley
Abstract
N‐2‐Nitrophenylsulfenyl imino dipeptides bearing various functional groups were successfully prepared by MnO2‐mediated oxidation and then subjected to diastereoselective indolylation. Each diastereomer of the adduct was selectively obtained from the same substrates using the appropriate chiral phosphoric acid catalysts. These transformations would be useful for synthesizing non‐canonical amino acid‐containing peptides as novel drug candidates.
N‐2‐Nitrophenylsulfenyl imino dipeptides bearing various functional groups were successfully prepared by MnO2‐mediated oxidation and then subjected to diastereoselective indolylation. Each diastereomer of the adduct was selectively obtained from the same substrates using the appropriate chiral phosphoric acid catalysts. These transformations would be useful for synthesizing non‐canonical amino acid‐containing peptides as novel drug candidates.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.202203120
- ISSN : 0947-6539
- eISSN : 1521-3765