2008年5月
Analysis of appositional bone formation using a novel rat experimental model
ORAL DISEASES
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- 巻
- 14
- 号
- 4
- 開始ページ
- 308
- 終了ページ
- 313
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1111/j.1601-0825.2007.01377.x
- 出版者・発行元
- BLACKWELL PUBLISHING
AIM: To analyze the process of appositional bone formation using our original rat experimental model.
MATERIALS AND METHODS: Rats were anesthetized and a ring made of polytetrafluorethylene was placed on the parietal bone surface in the surgical procedure. The time course of appositional bone formation was analyzed with histomorphometry and in situ hybridization for type I collagen and bone sialoprotein.
RESULTS: The rat experimental model allowed new bone to be formed on the pre-existing bone surface and persist for 12 weeks. We demonstrated that bone is apposed actively for the first 4 weeks and less actively thereafter.
CONCLUSIONS: The experimental model may contribute to biological analysis for appositional bone formation expected to occur in clinical procedures such as alveolar bone augmentation and sinus lifting.
MATERIALS AND METHODS: Rats were anesthetized and a ring made of polytetrafluorethylene was placed on the parietal bone surface in the surgical procedure. The time course of appositional bone formation was analyzed with histomorphometry and in situ hybridization for type I collagen and bone sialoprotein.
RESULTS: The rat experimental model allowed new bone to be formed on the pre-existing bone surface and persist for 12 weeks. We demonstrated that bone is apposed actively for the first 4 weeks and less actively thereafter.
CONCLUSIONS: The experimental model may contribute to biological analysis for appositional bone formation expected to occur in clinical procedures such as alveolar bone augmentation and sinus lifting.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1601-0825.2007.01377.x
- ISSN : 1354-523X
- Web of Science ID : WOS:000254954200004