Junko Okano

Profile Information

Degree: MD., Ph.D(Mar, 2006, Kyoto University)

J-GLOBAL ID: 201701007114511906
researchmap Member ID: B000272173

External link: https://shiga-keisei.com/

Research Interests

Research Areas

Other / Other / A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury" Junko Okano, Yuki Nakae, Takahiko Nakagawa, Miwako Katagi, Tomoya Terashima, Daisuke Nagakubo, Takashi Nakayama, Osamu Yoshie, Yoshihisa Suzuki and Hideto Kojima Scientific Reports, Mar 11, 2021
Other / Other / Bilateral plantar fibromatosis complicated by Dupuytren’s contracture” J Okano, A Arakawa, S Ogino, Y Suzuki Journal of Surgical Case Reports 2; 1-4, 2020.
Other / Other / Bone marrow-derived mononuclear cells relieve neuropathic pain after spinal nerve injury in mice” H Takemura, T Terashima, K Mori, M Katagi, J Okano, Y Suzuki, H Kojima Molecular Therapy-Methods and Clinical Develpment, 17; 657-665, 2020.
Other / Other / Transplantation of M2-deviated microglia promotes recovery of motor function after spinal Cord Injury in Mice.Kobashi S, Terashima T, Katagi M, Nakae Y, Okano J, Suzuki Y, Urushitani M, Kojima H.2020 Jan 8;28(1):254-265
Other / Other / Advanced Technology for Gene Delivery with Homing Peptides to Spinal Cord through Systemic Circulation in Mice.Terashima T,Ogawa N,Sato T,Katagi M,Nakae Y,Okano J,Maegawa H,Kojima H 2019.04.008(13)474-483
Other / Other / Stem cell factor induces polarization of microglia to the neuroprotective phenotype in vitro.Terashima T, Nakae Y, Katagi M, Okano J, Suzuki Y, Kojima H.2018 Oct 1;4(10):e00837
Other / Other / Impaired homeostasis in intact skin of type 1 diabetic mice.• J. Okano,Y. Suzuki,Tomoya Terashima,M. Katagi, January 2018 with 11 Reads
Other / Other / Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia.Terashima T, Ogawa N, Nakae Y, Sato T, Katagi M, Okano J, Maegawa H, Kojima H.2018 Jun 1;11:203-215.
Other / Other / Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice. Plos One.Okano J, Kojima H, Katagi M, Nakagawa T, Tereshima T, Nakae Y, Kubota M, Kurakane T,Okano J, Kojima H, Katagi M, Nakagawa T, Tereshima T, Nakae Y, Kubota M, Kurakane T,Okano J, Kojima H, Katagi M, Nakagawa T, Tereshima T, Nakae Y, Kubota M, Kurakane T,2016; 11 (11), e0166215.
Other / Other / 糖尿病性皮膚潰瘍の発生予防皮膚バリア機能破綻機序の解明と新規治療法の開発岡野純子 Medical Science Digest (42) p5, 2016.
Other / Other / Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation. Biochemical and Biophysical Research Communications.Okano J, Kojima H, Katagi M, Nakae Y, Terashima T, Nakagawa T, Kurakane T, Okamoto N, Udagawa J2015; 461 (4); 695-701.
Other / Other / Erythropoietin Receptor Antagonist Suppressed Ectopic Hemoglobin Synthesis in Xenografts of HeLa Cells to Promote Their Destruction. Plos One.Yasuda Y, Fujita M, Koike E, Obata K, Shiota M, Kotani Y, Musha T, Tsuji-Kawahara S, Satou T, Okano J, Mandai M2015; 10 (4); e0122458.
Other / Other / Roles of retinoic acid signaling in normal and abnormal development of the palate and tongue. Congenital anomalyes.Okano J, Udagawa J, Shiota K2014; 54 (2); 69-76.
Other / Other / Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS letters.Katagi M, Terashima T, Okano J, Uraba H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matuura K, Chan L, Kojima H2014; 588 (6); 1080-86.
Other / Other / Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. Journal of cell Science.Okano J, Lichti U, Mamiya S, Hamada H, Sakai Y, Morasso M2012; 287 (47) 39304-15.
Other / Other / Cutaneous retinoic acid levels determine hair follicle development and downgrowth. The Journal of biological chemistry.Okano J, Levy C, Lichti U, Sakai Y, Morasso M2012; 287 (47) 39304-15.
Other / Other / The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Developmental Dynamics.Okano J, Kimura W, Papaionnou VE, Miura N, Yamada G, Shiota K, Sakai Y2012; 241 Sep. 1744-56.
Other / Other / Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice. Dyvelopmental Dynamics.Okano J, Sakai Y, Shiota K.2008; 237 (10); 3059-70.
Other / Other / Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice. Toxicology and applied pharmacology.Okano J, Suzuki S, Shiota K.2007; 221 (1); 42-56.
Other / Other / Regional heterogeneity in the developing palate: morphological and molecular evidence for normal and abnormal palatogenesis. Congenital Anomalies.Okano J, Suzuki S, Shiota K2006; 46 (2); 49-54.
Other / Other / Transforming growth factor beta 2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. The International journal of developmental biology.Okano J, Takigawa T, Seki K, Shiota K, Ishibashi M.2005; 49 (1); 23-31.

Research History

Oct, 2016 - Present

Associate Professor (Associate Professor), Plastic and Reconstructive Surgery, Shiga University of Medical Science
Jul, 2008 - Jun, 2012

Postdoctorasl Fellow, National Institutes of Arthritis and Musculocutaneous Skin Diseases, National Institutes of Health
Oct, 2006 - Jul, 2008

Assistant Professor, Kyoto University

Education

Apr, 2002 - Mar, 2006

Graduate School of Medicine, Kyoto University
Apr, 1990 - Mar, 1996

Faculty of Medicine, Kyoto University

Committee Memberships

Aug, 2023 - Present

Editorial Board Member, PLOS ONE
Jul, 2021 - Jun, 2023

特別研究員等審査会専門委員、卓越研究員候補者選考委員会書面審査員及び国際事業委員会書面審査員・書面評価員, 日本学術振興会
Dec, 2019 - Mar, 2022

評議員, 関西形成外科学会
2019 - 2021

Female Trustee, Japan Society of Plastic and Reconstructive Surgery

Awards

Papers

Aberrant bone marrow-derived microglia in the hypothalamus may dysregulate appetite in diabetes

Katagi M, Nakae Y, Okano J, Fujino K, Tanaka T, Miyazawa I, Ohashi N, Nakagawa T, Kojima H

Biochem Biophys Res Commun., 682 132-137, Sep, 2023 Peer-reviewed
Complete remission of diabetes with a transient HDAC inhibitor and insulin in streptozotocin mice.

Hideto Kojima, Miwako Katagi, Junko Okano, Yuki Nakae, Natsuko Ohashi, Kazunori Fujino, Itsuko Miyazawa, Takahiko Nakagawa

Communications biology, 6(1) 637-637, Jun 13, 2023
Impaired circadian rhythm may disturb epithelialization in the wound healing of the skin in diabetic mice.

Junko Okano, Miwako Katagi, Takahiko Nakagawa, Hideto Kojima

Journal of dermatological science, Mar 21, 2023
A Case of Super-giant Basal Cell Carcinoma Initially Diagnosed as Multiple Traumas.

Junko Okano, Jun Arata, Atsuhiro Arakawa, Shuichi Ogino, Teruyo Yamashita

Plastic and reconstructive surgery. Global open, 11(2) e4812, Feb, 2023
Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects.

Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, Hideto Kojima

Scientific reports, 12(1) 20589-20589, Nov 29, 2022
Preliminary report of de novo adipogenesis using novel bioabsorbable implants and image evaluation using a porcine model

Shuichi Ogino, Atsushi Yamada, Yusuke Kambe, Takashi Nakano, Sunghee Lee, Michiharu Sakamoto, Yuki Kato, Saki Okumura, Junko Okano, Koji Yamauchi …

Journal of Artificial Organs, 25(3) 245-253, Sep, 2022 Peer-reviewed
Superchargeを付加した腹直筋皮弁を用いた乳房再建

岡野純子, 鈴木義久, 荒川篤宏, 荻野秀一, 河合由紀, 冨田香, 北村美奈, 山口剛, 谷眞至

滋賀医大雑誌, 35(1) 1-6, 2022 Peer-reviewedLead author
自家組織を用いた乳房再建術直後に右下腿痛を生じ、筋挫傷と判明した1症例

岡野純子, 荒川篤宏, 荻野秀一, 鈴木義久

日本形成外科学会会誌, 41(11) 685-685, Nov, 2021
GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS.

Natsuko Ohashi, Tomoya Terashima, Miwako Katagi, Yuki Nakae, Junko Okano, Yoshihisa Suzuki, Hideto Kojima

Scientific reports, 11(1) 12803-12803, Jun 17, 2021 Peer-reviewed
【ペット咬創への初期治療と機能・整容の改善[1]-統計・総論、その他-】動物咬傷の初期治療と感染予防

荒川篤宏, 鈴木義久, 岡野純子, 荻野秀一

形成外科, 64(2) 138-142, Feb, 2021
【ペット咬創への初期治療と機能・整容の改善[1]-統計・総論、その他-】動物咬傷の初期治療と感染予防

荒川篤宏, 鈴木義久, 岡野純子, 荻野秀一

形成外科, 64(2) 138-142, Feb, 2021 Peer-reviewed
胸部、腹部膿瘍よりActinotignum schaaliiを検出した１症例

木下愛, 岡野純子, 大澤真, 清水馨, 塚口扶美枝, 大輪田晴香, 池本敏行, 九嶋亮治

臨床微生物, 31(3) 170-175, 2021 Peer-reviewed
Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion.

Katagi M, Terashima T, Ohashi N, Nakae Y, Okano J, Kojima H

Communication Biology., 4(1) 1-14, 2021 Peer-reviewed
A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.

Okano J, Nakae Y, Nakagawa T, Katagi M, Terashima T, Kojima H

11 1-14, 2021 Peer-reviewedLead author
Bone-Marrow-Derived Mononuclear Cells Relieve Neuropathic Pain after Spinal Nerve Injury in Mice.

Hiroshi Takamura, Tomoya Terashima, Kanji Mori, Miwako Katagi, Junko Okano, Yoshihisa Suzuki, Shinji Imai, Hideto Kojima

Molecular therapy. Methods & clinical development, 17 657-665, Jun 12, 2020 Peer-reviewed
Bilateral plantar fibromatosis complicated by Dupuytren’s contracture

Junko Okano, Atsuhiro Arakawa, Shuichi Ogino, Yoshihisa Suzuki

Journal of Surgical Case Reports, 2020(2), Feb 1, 2020 Peer-reviewedLead author
Transplantation of M2-Deviated Microglia Promotes Recovery of Motor Function after Spinal Cord Injury in Mice.

Shuhei Kobashi, Tomoya Terashima, Miwako Katagi, Yuki Nakae, Junko Okano, Yoshihisa Suzuki, Makoto Urushitani, Hideto Kojima

Molecular therapy : the journal of the American Society of Gene Therapy, 28(1) 254-265, Jan 8, 2020 Peer-reviewed
エキスパンダーにて組織拡張中に肋骨骨折を認めた乳癌患者の2例

首藤加奈, 岡野純子, 石川奈美子, 沖野尚秀, 葛城遼平, 武田紘司, 武田孝輔, 鈴木義久

日本形成外科学会誌, 40 229-232, 2020 Peer-reviewedCorresponding author
Advanced technology for gene delivery with homing peptides to spinal cord through systemic circulation in mice.

Terashima T, Ogawa N, Sato T, Katagi M, Nakae Y, Okano J, Maegawa H, Kojima H

Mol Ther Methods Clin Dev, 13 474-483, Jun, 2019 Peer-reviewed
Stem cell factor induces polarization of microglia to the neuroprotective phenotype in vitro.

Terashima T, Nakae Y, Katagi M, Okano J, Suzuki Y, Kojima H

Heliyon, 4(10) e00837, Oct, 2018 Peer-reviewed

Misc.

両側性足底線維腫の1例

岡野純子, 鈴木義久, 荒川篤宏, 荻野秀一

日本形成外科学会会誌, 41(4) 229-229, Apr, 2021
次世代の人工神経シート状の人工神経による神経叢部の再生

鈴木義久, 石川奈美子, 岡野純子, 羽渕友則, 武田孝輔, 武田紘司

日本マイクロサージャリー学会学術集会プログラム・抄録集, 46回 103-103, Nov, 2019
骨髄単核球および神経栄養因子群発現骨髄間葉系幹細胞併用骨髄移植による筋萎縮性側索硬化症への治療戦略

寺島智也, 小橋修平, 渡辺保裕, 中西真実, 樫美和子, 中江由希, 岡野純子, 鈴木義久, 小島秀人

日本再生医療学会総会(Web), 18th ROMBUNNO.O‐28‐4 (WEB ONLY), 2019
糖尿病性神経障害の完治に向けた新規治療標的の同定

樫美和子, 寺島智也, 中江由希, 岡野純子, 鈴木義久, 小島秀人

日本再生医療学会総会(Web), 18th ROMBUNNO.O‐06‐6 (WEB ONLY), 2019
糖尿病性神経障害は神経細胞に細胞融合を仕掛ける造血幹細胞疾患である

小島秀人, 樫美和子, 寺島智也, 岡野純子, 中江由希, 鈴木義久

日本再生医療学会総会(Web), 18th ROMBUNNO.P‐01‐089 (WEB ONLY), 2019
実験的脳損傷モデルマウス作成の試み~脳外科の再生医療を目指して~

阪井田哲, 寺島智也, 樫美和子, 中江由希, 岡野純子, 鈴木義久, 小島秀人

日本再生医療学会総会(Web), 18th ROMBUNNO.P‐02‐064 (WEB ONLY), 2019
糖尿病創傷治癒における時計遺伝子の動態

岡野純子, 鈴木義久, 鈴木義久, 樫美和子, 中江由希, 小島秀人

日本形成外科学会基礎学術集会プログラム・抄録集, 27th 106, Sep, 2018
膵癌術後に生じた広範な腹壁欠損に対し双茎皮弁を用いて創閉鎖しえた一例

島田加奈, 鈴木義久, 岡野純子

日本形成外科学会会誌, 38(8) 449-449, Aug 20, 2018
マウス脊髄神経根障害における骨髄単核球注入療法の有用性

高村裕史, 鈴木義久, 小島秀人, 寺島智也, 岡野純子, 森幹士, 今井晋二

日本整形外科学会雑誌, 92(8) S1892-S1892, Aug, 2018
脊髄組織および脊髄内細胞標的化遺伝子輸送システムの開発と神経疾患への分子治療

寺島智也, 中江由希, 樫美和子, 岡野純子, 鈴木義久, 小島秀人

日本再生医療学会総会(Web), 17th ROMBUNNO.O‐03‐1 (WEB ONLY), 2018
傷害された皮膚に遊走する骨髄由来細胞の機能解析(第2報)

中江由希, 岡野純子, 樫美和子, 寺島智也, 鈴木義久, 小島秀人

日本再生医療学会総会(Web), 17th ROMBUNNO.P‐01‐055 (WEB ONLY), 2018
糖尿病性神経障害を作り出す異常な造血幹細胞の同定

樫美和子, 寺島智也, 小島秀人, 中江由希, 岡野純子, 鈴木義久

日本再生医療学会総会(Web), 17th ROMBUNNO.P‐01‐036 (WEB ONLY), 2018
糖尿病性神経障害は造血幹細胞疾患である

小島秀人, 樫美和子, 寺島智也, 岡野純子, 中江由希, 鈴木義久

日本再生医療学会総会(Web), 17th ROMBUNNO.O‐54‐2 (WEB ONLY), 2018
直腸切断術後の臀部皮膚欠損部を腹直筋皮弁で修復したクローン病に合併した難治性痔瘻の1例

植木智之, 園田寛道, 清水智治, 三宅亨, 岡野純子, 鈴木義久, 谷眞至

日本大腸肛門病学会雑誌, 70(抄録号) A226-A226, Sep, 2017
傷害された皮膚に遊走する骨髄由来細胞の形質および機能解析

岡野純子, 鈴木義久, 鈴木義久, 樫美和子, 中江由希, 寺島智也, 石川奈美子, 小島秀人

日本形成外科学会基礎学術集会プログラム・抄録集, 26th 120, Sep, 2017
骨髄内に存在する糖尿病幹細胞の同定

樫美和子, 寺島智也, 岡野純子, 岡野純子, 岡野純子, 中江由希, 鈴木義久, 鈴木義久, 小島秀人

再生医療, 16 443, Feb 1, 2017
糖尿病表皮の機能・分化異常は血糖コントロールにより治療可能である

岡野純子, 岡野純子, 岡野純子, 鈴木義久, 鈴木義久, 樫美和子, 寺島智也, 中江由希, 小島秀人

再生医療, 16 351, Feb 1, 2017
傷害された表皮に遊走する骨髄細胞の解析

中江由希, 中江由希, 岡野純子, 岡野純子, 岡野純子, 樫実和子, 寺島智也, 鈴木義久, 鈴木義久, 小島秀人

再生医療, 16 422, Feb 1, 2017
SCF刺激によるマウス初代培養ミクログリア細胞の細胞保護型への誘導

寺島智也, 小橋修平, 中江由希, 樫美和子, 岡野純子, 岡野純子, 岡野純子, 鈴木義久, 鈴木義久, 小島秀人

再生医療, 16 333, Feb 1, 2017
シート状の人工神経を用いた末梢神経分岐部の再生

鈴木義久, 石川奈美子, 岡野純子, 谷原正夫

日本マイクロサージャリー学会学術集会プログラム・抄録集, 43rd 211-211, Nov, 2016

Books and Other Publications

イラストレイテッド解剖学 (リッピンコットシリーズ)

塩田浩平, Dudek, Ronald W., 石村, 和敬, 塩田, 浩平 (Original Author(s): Kelly M. Harrell, Ronald W. Dudek)

丸善出版, Dec 26, 2020 (ISBN: 462130576X)
グラント解剖学実習

Detton, Alan J, 勝山, 裕

西村書店, Sep, 2019 (ISBN: 9784890134984)

Research Projects

Application of regenerative therapy to skin ulcer caused by deep dermal burn for scarless healing

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
難治性皮膚壊疽潰瘍に使用する異素材ハイブリッド型スキャフォールドの最適化

マルホ奨学寄付金, Apr, 2022 - Mar, 2023

岡野純子
Development of a novel therapy using bone marrow-derived cells for skin ulcer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2022

Okano Junko
Mechanism of brain injury caused by spinal cord injury

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Suzuki Yoshihisa
糖尿病性皮膚潰瘍における時計遺伝子の動態

アステラスResearch Support, Apr, 2019 - Mar, 2020

岡野純子
難治性皮膚壊疽潰瘍に対する新規治療法の開発

マルホ奨学寄付支援プログラム, Apr, 2019 - Mar, 2020

岡野純子
Novel therapeutic method for diabetic intractable ulcer: Development of targeting M2 macrophage activation vector

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Nakae Yuki, Suzuki Yoshihisa, Okano Junko, Kojima Hideto, Terashima Tomoya, Katagi Miwako
Development of new treatment for diabetes and its complications

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Katagi Miwako, KOJIMA HIDETO, TERASHIMA TOMOYA, OKANO JUNKO
糖尿病性皮膚壊疽潰瘍にたいする新規治療標的の同定

アストラゼネカ研究サポート, Apr, 2017 - Mar, 2019

岡野純子
ベトナムダナン病院における滋賀医科大学医学生の海外自主研修の遂行

医学系・看護系研究者海外渡航助成, 公益財団法人滋賀医学国際協力会, May, 2018 - Oct, 2018
Mechanism of diabetic complications in the skin

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Okano Junko, Morimoto Naoki
レチノイン酸の皮膚内モニタリングと新規アンチエイジング分子の同定

コスメトロジー研究振興財団, 2014 - 2017

岡野純子
Analysis of the relationship between the developmental disabilities in the offspring and the disturbance of the development of the brain including microglia by maternal undernutrition

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Udagawa Jun, OKANO Junko, HAYAKAWA Takahiro, TAKEI Shiro, KOJIMA Hideto, HINO Kodai, KIMURA Tomoko, KANEKO Shunya, HARASAWA Toshiya, KONO Tadaaki
小児期発症１型糖尿病患者に対する非侵襲的な血糖モニタリングの開発

日本女医学術研究助成, 2014 - 2015

岡野純子
Development of novel therapy for diabetic ulcer

Banyu Foundataion Research Grant, 2013 - 2015
糖尿病性皮膚症の病態基盤と新規治療標的の同定

滋賀医科大学, Apr, 2012 - Mar, 2013

岡野純子
脂腺細胞の発生分化におけるレチノイン酸シグナリングを中心とした分子機構の解明及び臨床応用に向けた試み

滋賀医科大学, 2012 - 2013

岡野純子
レチノイン酸とアラキドン酸経路を用いた育毛剤の開発

アステラス病態代謝研究会, 2012 - 2013

岡野純子
皮膚の正常及び異常発生の分子機構の解明

京都大学教育研究振興財団, 2009 - 2011

岡野純子
Cyp26(レチノイン酸分解酵素)の役割を中心とした皮膚発生における分子機構

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, 2008 - 2010

岡野純子, 塩田浩平, 坂井靖夫

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