Takahashi Masaki

Profile Information

Affiliation: The Institute of Medical Science, The University of Tokyo

J-GLOBAL ID: 201801017685646275
researchmap Member ID: B000300637

Research Areas

Papers

Anti-TGF-β1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model

Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura

Molecular Therapy - Nucleic Acids, Jun 29, 2022 Peer-reviewedLead authorCorresponding author
Nucleic Acid Aptamers Emerging as Modulators of G-Protein-Coupled Receptors: Challenge to Difficult Cell Surface Proteins

Masaki Takahashi

Cells, 11(11) 1825-1825, Jun 2, 2022 Peer-reviewedLead authorCorresponding author
Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2

Masaki Takahashi, Ryo Amano, Michiru Ozawa, Anna Martinez, Kazumasa Akita, Yoshikazu Nakamura

Proceedings of the National Academy of Sciences, 118(18) e2019497118-e2019497118, May 4, 2021 Peer-reviewedLead authorCorresponding author
Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain

Masashi Fukuoka, Masaki Takahashi, Hiromi Fujita, Tomoko Chiyo, H. Akiko Popiel, Shoko Watanabe, Hirokazu Furuya, Miho Murata, Keiji Wada, Takashi Okada …

Molecular Therapy - Nucleic Acids, 11 79-90, Jun 1, 2018 Peer-reviewedLead author
Aptamers targeting cell surface proteins

Masaki Takahashi

Biochimie, 145 63-72, Feb 1, 2018 Peer-reviewedCorresponding author
Single-round isolation of diverse RNA aptamers from a random sequence pool

Imashimizu M, Takahashi M, Amano R, Nakamura Y

Biology Methods & Protocols, 2(1) bpy004, 2018 Peer-reviewed
Nonstop-mRNA decay machinery is involved in the clearance of mRNA 5 '-fragments produced by RNAi and NMD in Drosophila melanogaster cells

Yoshifumi Hashimoto, Masaki Takahashi, Eri Sakota, Yoshikazu Nakamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 484(1) 1-7, Feb, 2017 Peer-reviewed
The efficient cell-SELEX strategy, Icell-SELEX, using isogenic cell lines for selection and counter-selection to generate RNA aptamers to cell surface proteins

Masaki Takahashi, Eri Sakota, Yoshikazu Nakamura

BIOCHIMIE, 131 77-84, Dec, 2016 Peer-reviewedLead author
Neighbors' death is required for surviving human adenocarcinoma PC-9 cells in an early stage of gefitinib treatment

Masaki Takahashi, Masashi Fukuoka, Katsuji Yoshioka, Hirohiko Hohjoh

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 479(2) 393-397, Oct, 2016 Peer-reviewedLead author
Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes

Shu Aizawa, Yuuki Fujiwara, Viorica Raluca Contu, Katsunori Hase, Masayuki Takahashi, Hisae Kikuchi, Chihana Kabuta, Keiji Wada, Tomohiro Kabuta

AUTOPHAGY, 12(3) 565-578, 2016 Peer-reviewed
Normalization of Overexpressed alpha-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference

Masaki Takahashi, Mari Suzuki, Masashi Fukuoka, Nobuhiro Fujikake, Shoko Watanabe, Miho Murata, Keiji Wada, Yoshitaka Nagai, Hirohiko Hohjoh

MOLECULAR THERAPY-NUCLEIC ACIDS, 4 e241, May, 2015 Peer-reviewedLead author
A novel measurement of allele discrimination for assessment of allele-specific silencing by RNA interference

Masaki Takahashi, Hirohiko Hohjoh

MOLECULAR BIOLOGY REPORTS, 41(11) 7115-7120, Nov, 2014 Peer-reviewedLead author
A functional involvement of ABCE1, eukaryotic ribosome recycling factor, in nonstop mRNA decay in Drosophila melanogaster cells

Isao Kashima, Masaki Takahashi, Yoshifumi Hashimoto, Eri Sakota, Yoshikazu Nakamura, Toshifumu Inada

BIOCHIMIE, 106 10-16, Nov, 2014 Peer-reviewed
Gene Silencing Mediated by Endogenous MicroRNAs under Heat Stress Conditions in Mammalian Cells

Masashi Fukuoka, Mariko Yoshida, Akiko Eda, Masaki Takahashi, Hirohiko Hohjoh

PLOS ONE, 9(7) e103130, Jul, 2014 Peer-reviewed
Thyroid hormone-dependent development of the GABAergic pre- and post-synaptic components in the rat hippocampus

Erika Sawano, Masaki Takahashi, Takayuki Negishi, Tomoko Tashiro

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 31(8) 751-761, Dec, 2013 Peer-reviewed
Specific Inhibition of Tumor Cells by Oncogenic EGFR Specific Silencing by RNA interference

Masaki Takahashi, Tomoko Chiyo, Takashi Okada, Hirohiko Hohjoh

PLOS ONE, 8(8) e73214, Aug, 2013 Peer-reviewedLead author
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity

Tomohiro Kabuta, Takeshi Mitsui, Masaki Takahashi, Yuuki Fujiwara, Chihana Kabuta, Chiho Konya, Yukihiro Tsuchiya, Yusuke Hatanaka, Kenko Uchida, Hirohiko Hohjoh …

Journal of Biological Chemistry, 288(18) 12615-12626, May 3, 2013 Peer-reviewed
Reduction of Type IV Collagen by Upregulated miR-29 in Normal Elderly Mouse and klotho-Deficient, Senescence-Model Mouse

Masaki Takahashi, Akiko Eda, Tatsunobu Fukushima, Hirohiko Hohjoh

PLOS ONE, 7(11) e48974, Nov, 2012 Peer-reviewedLead author
Allele-specific silencing against the ALK2 mutants, R206H and G356D, in fibrodysplasia ossificans progressiva (FOP)

H. Furuya, M. Takahashi, T. Katagiri, H. Hohjoh

NEUROMUSCULAR DISORDERS, 22(9-10) 906-906, Oct, 2012 Peer-reviewed
Disease-causing allele-specific silencing against the ALK2 mutants, R206H and G356D, in fibrodysplasia ossificans progressiva

M. Takahashi, T. Katagiri, H. Furuya, H. Hohjoh

GENE THERAPY, 19(7) 781-785, Jul, 2012 Peer-reviewedLead author

Misc.

ウイルス様粒子とin silico解析を用いたデングウイルス中和アプタマーの創製

天野亮, 一ノ瀬顕子, 浜田道昭, 中村義一, 中村義一, 高橋理貴

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
ウイルス様粒子を用いたGPCR結合RNAアプタマーの創製

天野亮, 高橋理貴, MARTINEZ Anna, 秋田一雅, 中村義一, 中村義一

日本分子生物学会年会プログラム・要旨集(Web), 41st, 2018
ミセル化GPCRを標的としたSELEX手法の開発

MARITINEZ Anna, 秋田一雅, 今井博貴, 猪股恵美礼, 高橋理貴, 天野亮, 中村義一, 中村義一

日本分子生物学会年会プログラム・要旨集(Web), 41st, 2018
Huntington舞踏病でのRNAiを用いた原因遺伝子特異的ノックダウン法の開発

古谷博和, 高橋理貴, 村田美穂, 渡邊荘子, 金澤一郎, 和田圭司, 北條浩彦

神経治療学, 28(5) 564-564, Sep, 2011
トリプレット・リピート病原因遺伝子に対するテーラーメイドRNAiノックダウン

高橋理貴, 北條浩彦

実験医学, 29(6) 931-934, Apr 1, 2011
新規プルダウン法を用いたリピート病原因対立遺伝子の優先的回収法とSNPを指標とした病因対立遺伝子の特異的RNAiノックダウン(Identification of triplet repeat disease-causing alleles by a novel pull-down method and disease-causing allele specific silencing by RNAi)

高橋理貴, 渡邉荘子, 村田美穂, 古谷博和, 金澤一郎, 和田圭司, 北條浩彦

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回 4P-1123, Dec, 2010
Diphenylarsinic acid induced oxidative stress and expression of neuroactive and vasoactive peptides in cerebellar astrocytes

Takayuki Negishi, Masaki Takahashi, Kohshi Oyanagi, Hiroaki Ohnishi, Seishiro Hirano, Tomoko Tashiro

NEUROSCIENCE RESEARCH, 68 E417-E418, 2010
Identification of genes mediating thyroid hormone action in the developing mouse cerebellum

M. Takahashi, T. Negishi, T. Tashiro

JOURNAL OF NEUROCHEMISTRY, 102 234-234, Aug, 2007
Alterations of gene expression profiles in the developing brain by chemicals disrupting thyroid hormone-dependent signals

Takayuki Negishi, Masaki Takahashi, Yasuhiro Yoshikawa, Tomoko Tashiro

NEUROSCIENCE RESEARCH, 55 S47-S47, 2006

Professional Memberships

Research Projects

Development of visualized nano-DDS agents for brain by aptamers and quantum dots

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2022 - Mar, 2024
AIアプタマー創薬プロジェクト

戦略的創造研究推進事業（CREST）, JST, 2021 - 2023
Development of multi-functional siRNA-aptamer chimera for virus infections

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Takahashi Masaki
人工知能技術を用いた革新的アプタマー創薬システムの開発

戦略的創造研究推進事業（CREST）, JST, 2018 - 2020

浜田道昭
ウイルス様粒子を新規材料とした膜タンパク質結合RNAアプタマー創製法の開発

挑戦的研究(萌芽), 日本学術振興会(JSPS), 2017 - 2018

高橋理貴
GPCRを標的とするRNAアプタマー創薬基盤技術の開発

創薬基盤推進研究事業, 日本医療研究開発機構(AMED), 2016 - 2018

秋田一雅
難治性神経変性疾患に対する神経シナプス形成を促進させるマイクロＲＮＡの補充による新規治療法の開発と確立

難治性疾患実用化研究事業, 日本医療研究開発機構(AMED), 2014 - 2016

北條浩彦
ハンチントン病核内凝集体形成における非コードRNA・MENbの関与についての研究

若手研究(B), 日本学術振興会(JSPS), 2013 - 2015

高橋理貴
ハンチントン病RNAi治療を目指したSNP識別アレル特異的RNAi技術の開発

研究活動スタート支援, 日本学術振興会(JSPS), 2009 - 2010

高橋理貴
脳機能発達に対する環境化学物質の影響と攪乱標的の一つ甲状腺ホルモンの機能解明

特別研究員奨励費, 日本学術振興会(JSPS), 2007 - 2008

高橋理貴

Industrial Property Rights

特願2019-126940 ＴＧＦ－β１に対するアプタマー及びその使用

中村義一, 高橋理貴, 橋本芳史
特許第5996431号優性変異遺伝子発現抑制剤

北條浩彦, 高橋理貴
特許第5941842号優性アレル発現抑制剤

北條浩彦, 高橋理貴
特許第5716217号長鎖繰返し配列を含有する遺伝子又は遺伝子産物の選択又は優先的回収方法

北條浩彦, 高橋理貴
WO2012-043633 優性変異遺伝子発現抑制剤

北條浩彦, 高橋理貴
WO2011-158924 優性アレル発現抑制剤

北條浩彦, 高橋理貴
特開2011-125219 長鎖繰返し配列を含有する遺伝子又は遺伝子産物の選択又は優先的回収方法

北條浩彦, 高橋理貴

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Research Areas

Papers

Misc.

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Research Projects

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