2014年10月
Homeostatic inflammation in innate immunity.
Current opinion in immunology
- ,
- 巻
- 30
- 号
- 開始ページ
- 85
- 終了ページ
- 90
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.coi.2014.08.003
Innate immune sensors respond not only to microbial products but also to endogenous metabolites such as nucleic acids (NAs) and lipids. Toll-like receptors (TLRs) deliver a signal from the plasma membrane and also from endolysosomes, where NAs and lipids are catabolized. Interaction of TLRs with metabolites in endolysosomes leads to homeostatic TLR activation. Dendritic cells expressing NA-sensing TLRs are steadily activated by metabolites derived from the host or commensals and produce type I IFNs, thereby provoking various types of inflammatory conditions. Here, we discuss how homeostatic inflammation is induced by innate immune sensors and is involved in maintaining immune homeostasis and causing non-infectious inflammatory diseases.
- リンク情報
- ID情報
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- DOI : 10.1016/j.coi.2014.08.003
- PubMed ID : 25190609