論文

査読有り 国際誌
2018年11月23日

Dorsal-zone-specific reduction of sensory neuron density in the olfactory epithelium following long-term exercise or caloric restriction.

Scientific reports
  • Ayinuer Tuerdi
  • ,
  • Shu Kikuta
  • ,
  • Makoto Kinoshita
  • ,
  • Teru Kamogashira
  • ,
  • Kenji Kondo
  • ,
  • Shinichi Iwasaki
  • ,
  • Tatsuya Yamasoba

8
1
開始ページ
17300
終了ページ
17300
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-018-35607-w

Exercise (Ex) and caloric restriction (CR) reduce oxidative stress and improve organ function. For instance, voluntary Ex or CR is known to reduce age-related cochlear damage in male C57BL/6J mice. However, the effect of Ex and CR on the olfactory system is unknown. In this study, we confirmed the positive effect of Ex and CR on age-related cochlear damage, but found that Ex and CR affected negatively cell dynamics in the olfactory epithelium (OE) by reducing the number of mature olfactory sensory neurons (OSNs) and increasing the number of proliferative basal cells and apoptotic OSNs in the dorsal zone of the olfactory epithelium (OE), which contains neurons expressing NADPH quinone oxido-reductase 1 (NQO1). In addition, these interventions resulted in lower odor-induced c-fos expression in areas of the olfactory bulb receiving projections from dorsal-zone OSNs than in areas receiving ventral-zone projections. Further, we observed substantial oxidative stress in NQO1-positive cells and apoptotic OSNs in the dorsal zone in Ex and CR animals. These results suggest that, in contrast to their positive effects in other organs, Ex and CR facilitate oxidative stress and negatively impact structure and function in dorsal-zone OSNs, probably in association with NQO1 bioactivation.

リンク情報
DOI
https://doi.org/10.1038/s41598-018-35607-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30470811
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251928
URL
http://europepmc.org/abstract/med/30470811

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