金政利幸 (Toshiyuki Kanemasa) - マイポータル

基本情報

所属: 大阪大学共創機構産学官連携オフィス

J-GLOBAL ID: 202101009481353840
researchmap会員ID: R000023399

論文

Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus.

Yuki Azuma, Katsumi Koike, Hiroki Chiba, Aki Mitamura, Hiroki Tsuji, Sachiko Kawasaki, Takaaki Yokota, Toshiyuki Kanemasa, Yasuhide Morioka, Tsutomu Suzuki …

Biological & pharmaceutical bulletin 2023年10月19日
Preventive effects of naldemedine, peripherally acting μ-opioid receptor antagonist, on morphine-induced nausea and vomiting in ferrets.

Toshiyuki Kanemasa, Takanobu Matsuzaki, Katsumi Koike, Minoru Hasegawa, Tsutomu Suzuki

Life sciences 257 118048-118048 2020年9月15日
The antagonistic activity profile of naloxone in μ-opioid receptor agonist-induced psychological dependence.

Atsushi Nakamura, Kana Yasufuku, Shinji Shimada, Hiroyuki Aritomi, Youko Furue, Hiroki Chiba, Mami Muramoto, Kenji Takase, Katsumi Koike, Tomoko Matsumoto …

Neuroscience letters 735 135177-135177 2020年9月14日
Pharmacological Profile of Naldemedine, a Peripherally Acting μ-Opioid Receptor Antagonist: Comparison with Naloxone and Naloxegol.

Toshiyuki Kanemasa, Katsumi Koike, Kenji Takase, Tohko Arai, Atsushi Nakamura, Yasuhide Morioka, Minoru Hasegawa

The Journal of pharmacology and experimental therapeutics 373(3) 438-444 2020年6月
Naldemedine: Peripherally Acting Opioid Receptor Antagonist for Treating Opioid-induced Adverse Effects.

Masanao Inagaki, Toshiyuki Kanemasa, Takaaki Yokota

Current topics in medicinal chemistry 20(31) 2830-2842 2020年
Pharmacologic effects of naldemedine, a peripherally acting μ-opioid receptor antagonist, in in vitro and in vivo models of opioid-induced constipation.

Toshiyuki Kanemasa, Katsumi Koike, Tohko Arai, Hiroko Ono, Narumi Horita, Hiroki Chiba, Atsushi Nakamura, Yasuhide Morioka, Tsuyoshi Kihara, Minoru Hasegawa

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 31(5) e13563 2019年5月
Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects.

Masanao Inagaki, Masaharu Kume, Yoshinori Tamura, Shinichiro Hara, Yoshihisa Goto, Nobuhiro Haga, Tsuyoshi Hasegawa, Takashi Nakamura, Katsumi Koike, Shuuichi Oonishi …

Bioorganic & medicinal chemistry letters 29(1) 73-77 2019年1月1日
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.

Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita …

Pain 159(5) 939-947 2018年5月
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.

Naoki Tsuno, Akira Yukimasa, Osamu Yoshida, Shinji Suzuki, Hiromi Nakai, Tomoyuki Ogawa, Motohiro Fujiu, Kenji Takaya, Azusa Nozu, Hiroki Yamaguchi …

Bioorganic & medicinal chemistry 25(7) 2177-2190 2017年4月1日
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.

Naoki Tsuno, Akira Yukimasa, Osamu Yoshida, Shinji Suzuki, Hiromi Nakai, Tomoyuki Ogawa, Motohiro Fujiu, Kenji Takaya, Azusa Nozu, Hiroki Yamaguchi …

Bioorganic & medicinal chemistry letters 26(20) 4936-4941 2016年10月15日
Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.

Naoki Tsuno, Akira Yukimasa, Osamu Yoshida, Yusuke Ichihashi, Takatsugu Inoue, Tatsuhiko Ueno, Hiroki Yamaguchi, Hidetoshi Matsuda, Satoko Funaki, Natsue Yamanada …

Bioorganic & medicinal chemistry letters 26(20) 4930-4935 2016年10月15日
Effect of estrogen on morphine- and oxycodone-induced antinociception in a female femur bone cancer pain model.

Hiroko Ono, Atsushi Nakamura, Toshiyuki Kanemasa, Gaku Sakaguchi, Shunji Shinohara

European journal of pharmacology 773 1-12 2016年2月15日
Morphine and oxycodone, but not fentanyl, exhibit antinociceptive effects mediated by G-protein inwardly rectifying potassium (GIRK) channels in an oxaliplatin-induced neuropathy rat model.

Tomoe Kanbara, Atsushi Nakamura, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Toshiyuki Kanemasa

Neuroscience letters 580 119-24 2014年9月19日
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.

Laykea Tafesse, Toshiyuki Kanemasa, Noriyuki Kurose, Jianming Yu, Toshiyuki Asaki, Gang Wu, Yuka Iwamoto, Yoshitaka Yamaguchi, Chiyou Ni, John Engel …

Journal of medicinal chemistry 57(15) 6781-94 2014年8月14日
Effect of the norepinephrine transporter (NET) inhibition on μ-opioid receptor (MOR)-induced anti-nociception in a bone cancer pain model.

Hiroko Ono, Atsushi Nakamura, Tomoe Kanbara, Kazuhisa Minami, Shunji Shinohara, Gaku Sakaguchi, Toshiyuki Kanemasa

Journal of pharmacological sciences 125(3) 264-73 2014年
Establishment of opioid-induced rewarding effects under oxaliplatin- and Paclitaxel-induced neuropathy in rats.

Tomohisa Mori, Tomoe Kanbara, Masato Harumiya, Yoshiyuki Iwase, Aki Masumoto, Sachiko Komiya, Atsushi Nakamura, Masahiro Shibasaki, Toshiyuki Kanemasa, Gaku Sakaguchi …

Journal of pharmacological sciences 126(1) 47-55 2014年
The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model.

Tomoe Kanbara, Atsushi Nakamura, Keiko Takasu, Koichi Ogawa, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Minoru Hasegawa, Gaku Sakaguchi, Toshiyuki Kanemasa

Journal of pharmacological sciences 126(3) 264-73 2014年
Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

Yoshihiro Ida, Toru Nemoto, Shigeto Hirayama, Hideaki Fujii, Yumiko Osa, Masayuki Imai, Takashi Nakamura, Toshiyuki Kanemasa, Akira Kato, Hiroshi Nagase

Bioorganic & medicinal chemistry 20(2) 949-61 2012年1月15日
Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models.

Kazuhisa Minami, Minoru Hasegawa, Hisanori Ito, Atsushi Nakamura, Takako Tomii, Mitsunobu Matsumoto, Satoshi Orita, Syuichi Matsushima, Takako Miyoshi, Koichi Masuno …

Journal of pharmacological sciences 111(1) 60-72 2009年9月
Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.

Hiroshi Nagase, Yumiko Osa, Toru Nemoto, Hideaki Fujii, Masayuki Imai, Takashi Nakamura, Toshiyuki Kanemasa, Akira Kato, Hiroaki Gouda, Shuichi Hirono

Bioorganic & medicinal chemistry letters 19(10) 2792-5 2009年5月15日

もっとみる

MISC

Effects of Naldemedine: A Peripherally Acting Mu-Opioid Receptor Antagonist in Rat Models of Opioid-Induced Constipation

Toshiyuki Kanemasa, Katsami Koike, Tohko Arai, Narumi Horita, Hiroki Chiba, Tsuyoshi Kihara, Minora Hasegawa

AMERICAN JOURNAL OF GASTROENTEROLOGY 110 S578-S578 2015年10月
ラットを用いた抗がん剤誘発神経障害性疼痛モデルに対するオピオイド鎮痛薬の有効性

蒲原智絵, 中邨篤史, 長谷川稔, 芝崎真裕, 森友久, 鈴木勉, 阪口岳, 金政利幸

日本癌治療学会誌 48(3) 2991-2991 2013年9月
Paclitaxelおよびoxaliplatin誘発疼痛のオピオイド鎮痛薬誘発精神依存に与える影響

森友久, 中邨篤史, 春宮昌人, 増元亜紀, 蒲原智絵, 芝崎真裕, 金政利幸, 鈴木勉

日本癌治療学会誌 48(3) 2992-2992 2013年9月
Contraction of guinea pig lung parenchyma by pancreatic type phospholipase A_2 via its specific binding site

KANEMASA T.

FEBS Lett 303 217-220 1992年

金政利幸

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