論文

国際誌
2022年2月

Cotton rats (Sigmodon hispidus) with a high prevalence of hydrocephalus without clinical symptoms.

Neuropathology : official journal of the Japanese Society of Neuropathology
  • Daisuke Kondoh
  • ,
  • Teppei Nakamura
  • ,
  • Erika Tsuji
  • ,
  • Marina Hosotani
  • ,
  • Osamu Ichii
  • ,
  • Takao Irie
  • ,
  • Takashi Mishima
  • ,
  • Ken-Ichi Nagasaki
  • ,
  • Yasuhiro Kon

42
1
開始ページ
16
終了ページ
27
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/neup.12776

Normal-pressure hydrocephalus (NPH) is a condition in which the ventricle is enlarged without elevated cerebrospinal fluid pressure, and it generally develops in later life and progresses slowly. A complete animal model that mimics human idiopathic NPH has not yet been established, and the onset mechanisms and detailed pathomechanisms of NPH are not fully understood. Here, we demonstrate a high spontaneous prevalence (34.6%) of hydrocephalus without clinical symptoms in inbred cotton rats (Sigmodon hispidus). In all 46 hydrocephalic cotton rats, the severity was mild or moderate and not severe. The dilation was limited to the lateral ventricles, and none of the hemorrhage, ventriculitis, meningitis, or tumor formation was found in hydrocephalic cotton rats. These findings indicate that the type of hydrocephalus in cotton rats is similar to that of communicating idiopathic NPH. Histopathological examinations revealed that the inner granular and pyramidal layers (layers IV and V) of the neocortex became thinner in hydrocephalic brains. A small number of pyramidal cells were positive for Fluoro-Jade C (a degenerating neuron marker) and ionized calcium-binding adaptor molecule 1 (Iba1)-immunoreactive microglia were in contact with the degenerating neurons in the hydrocephalic neocortex, suggesting that hydrocephalic cotton rats are more or less impaired projections from the neocortex. This study highlights cotton rats as a candidate for novel models to elucidate the pathomechanism of idiopathic NPH. Additionally, cotton rats have some noticeable systemic pathological phenotypes, such as chronic kidney disease and metabolic disorders. Thus, this model might also be useful for researching the comorbidities of NPH to other diseases.

リンク情報
DOI
https://doi.org/10.1111/neup.12776
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34957592
ID情報
  • DOI : 10.1111/neup.12776
  • PubMed ID : 34957592

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