論文

査読有り 最終著者 本文へのリンクあり 国際誌
2018年3月6日

Acetaminophen administration and the risk of acute kidney injury: A self-controlled case series study

Clinical Epidemiology
  • Shusuke Hiragi
  • ,
  • Hiroyuki Yamada
  • ,
  • Tatsuo Tsukamoto
  • ,
  • Kazuki Yoshida
  • ,
  • Naoya Kondo
  • ,
  • Takeshi Matsubara
  • ,
  • Motoko Yanagita
  • ,
  • Hiroshi Tamura
  • ,
  • Tomohiro Kuroda

10
開始ページ
265
終了ページ
276
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2147/CLEP.S158110
出版者・発行元
DOVE MEDICAL PRESS LTD

Background: Acetaminophen (APAP) is frequently used for analgesia and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for the kidneys. However, there is little epidemiological evidence of the association between APAP and acute kidney injury (AKI). Objectives: To examine the association between APAP and AKI using the self-controlled case series (SCCS) method, which is a novel strategy to control between-person confounders by comparing the risk and reference periods in each patient. Methods: We performed SCCS in 1,871 patients (39.9% female) who were administered APAP and subsequently developed AKI, by reviewing electronically stored hospital information system data from May 2011 to July 2016. We used conditional Poisson regression to compare each patient’s risk and reference period. As a time-varying confounder, we adjusted the status of liver and kidney functions, systemic inflammation, and exposure to NSAIDs. Results: We identified 5,650 AKI events during the 260,549 person-day observation period. The unadjusted incidences during the reference and exposure periods were 2.01/100 and 3.12/100 person-days, respectively. The incidence rate ratio adjusted with SCCS was 1.03 (95% confidence interval [CI]: 0.95–1.12). When we restricted endpoints as stage 2 AKI-and stage 3 AKI-level creatinine elevations, the incidence rate ratios were 1.20 (95% CI 0.91–1.58) and 1.20 (95% CI 0.62–2.31), respectively, neither of which was statistically significant. Conclusion: Our findings added epidemiological information for the relationship between APAP administration and AKI development. The results indicated scarce association between APAP and AKI, presumably supporting the general physicians’ impression that APAP is safer for kidney.

リンク情報
DOI
https://doi.org/10.2147/CLEP.S158110
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29563839
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846761
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000427423600003&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047770971&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85047770971&origin=inward
ID情報
  • DOI : 10.2147/CLEP.S158110
  • ISSN : 1179-1349
  • eISSN : 1179-1349
  • PubMed ID : 29563839
  • PubMed Central 記事ID : PMC5846761
  • SCOPUS ID : 85047770971
  • Web of Science ID : WOS:000427423600003

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