論文

査読有り
2017年12月

Granulomatous interstitial nephritis due to chronic lymphocytic leukemia: a case report

BMC NEPHROLOGY
  • Yasuo Suzuki
  • ,
  • Kan Katayama
  • ,
  • Eiji Ishikawa
  • ,
  • Shoko Mizoguchi
  • ,
  • Keiko Oda
  • ,
  • Yosuke Hirabayashi
  • ,
  • Ayumi Haruki
  • ,
  • Takayasu Ito
  • ,
  • Mika Fujimoto
  • ,
  • Tomohiro Murata
  • ,
  • Masaaki Ito

18
1
開始ページ
348
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12882-017-0775-3
出版者・発行元
BIOMED CENTRAL LTD

Background: Renal failure due to the infiltration of chronic lymphocytic leukemia (CLL) cells into the tubulointerstitial area of the kidney is uncommon. Furthermore, granulomatous interstitial nephritis (GIN) is a rare histological diagnosis in patients undergoing a renal biopsy. We herein report a case of GIN due to the diffuse infiltration of CLL cells in a patient who developed progressive renal failure.
Case presentation: The patient was a 55-year-old man who had been diagnosed with CLL 4 years earlier and who had been followed up without treatment. Although his serum creatinine level had remained normal for three and a half years, it started to increase in the six months prior to his presentation. A urinalysis showed mild proteinuria without any hematuria at the time of presentation. A renal biopsy revealed the diffuse infiltration of CLL cells into the tubulointerstitial area with non-caseating epithelioid cell granulomas. Despite cyclophosphamide treatment, his renal function did not improve, and he ultimately required maintenance hemodialysis.
Conclusion: When progressive renal failure is combined with CLL, GIN due to the direct infiltration of CLL cells should be considered as a differential diagnosis.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1186/s12882-017-0775-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29197349
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000416929900003&DestApp=WOS_CPL

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