2011年3月
Radiological and histologic studies of the mandibular cortex of ovariectomized monkeys
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
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- 巻
- 111
- 号
- 3
- 開始ページ
- 372
- 終了ページ
- 380
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tripleo.2010.12.003
- 出版者・発行元
- MOSBY-ELSEVIER
Objective. The objective was to study the radiological and histologic changes in the mandibular cortices of ovariectomized monkeys.
Study design. Twelve female, adult, Cynomolgus monkeys (Macaca fascicularis) were used. Under anesthesia, 1 group was bilaterally ovariectomized (OVX), and the other (control group) underwent sham surgery. Seventy-six weeks after surgery, the monkeys were humanely killed, their mandibles were excised, and their mandibular inferior cortices (MIC) and adjacent cortices were examined histologically and with panoramic radiographs and micro computed tomography.
Results. Striped shadows were seen on the endosteal side of the OVX cortices on panoramic radiographs. Histologic observation revealed many enlarged pores with eroded surfaces and calcein labeling (indicating osteon remodeling) in the OVX cortices.
Conclusions. In the MIC and adjacent cortices of OVX monkeys, enlarged Haversian canals were seen and there were indications of a high rate of bone turnover. The enlarged Haversian canals resulted in striped shadows and unclear endosteal margins on radiographic images. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:372-380)
Study design. Twelve female, adult, Cynomolgus monkeys (Macaca fascicularis) were used. Under anesthesia, 1 group was bilaterally ovariectomized (OVX), and the other (control group) underwent sham surgery. Seventy-six weeks after surgery, the monkeys were humanely killed, their mandibles were excised, and their mandibular inferior cortices (MIC) and adjacent cortices were examined histologically and with panoramic radiographs and micro computed tomography.
Results. Striped shadows were seen on the endosteal side of the OVX cortices on panoramic radiographs. Histologic observation revealed many enlarged pores with eroded surfaces and calcein labeling (indicating osteon remodeling) in the OVX cortices.
Conclusions. In the MIC and adjacent cortices of OVX monkeys, enlarged Haversian canals were seen and there were indications of a high rate of bone turnover. The enlarged Haversian canals resulted in striped shadows and unclear endosteal margins on radiographic images. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:372-380)
- リンク情報
- ID情報
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- DOI : 10.1016/j.tripleo.2010.12.003
- ISSN : 1079-2104
- eISSN : 1528-395X
- PubMed ID : 21310357
- Web of Science ID : WOS:000287128300025