論文

査読有り 国際誌
2018年2月1日

Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.

Bioorganic & medicinal chemistry
  • Ayumu Niida
  • Yoko Kanematsu-Yamaki
  • Tomoko Asakawa
  • Yoshimasa Ishimura
  • Hisashi Fujita
  • Kouta Matsumiya
  • Naoki Nishizawa
  • Yusuke Adachi
  • Taisuke Mochida
  • Kazue Tsuchimori
  • Mariko Yoneyama-Hirozane
  • Junichi Sakamoto
  • Hideki Hirabayashi
  • Hideo Fukui
  • Shiro Takekawa
  • Taiji Asami
  • 全て表示

26
3
開始ページ
566
終了ページ
572
記述言語
英語
掲載種別
DOI
10.1016/j.bmc.2017.12.014

Neuropeptide Y2 receptor (Y2R) agonism is an important anorectic signal and a target of antiobesity drug discovery. Recently, we synthesized a short-length Y2R agonist, PYY-1119 (4-imidazolecarbonyl-[d-Hyp24,Iva25,Pya(4)26,Cha27,36,γMeLeu28,Lys30,Aib31]PYY(23-36), 1) as an antiobesity drug candidate. Compound 1 induced marked body weight loss in diet-induced obese (DIO) mice; however, 1 also induced severe vomiting in dogs at a lower dose than the minimum effective dose administered to DIO mice. The rapid absorption of 1 after subcutaneous administration caused the severe vomiting. Polyethylene glycol (PEG)- and alkyl-modified derivatives of 1 were synthesized to develop Y2R agonists with improved pharmacokinetic profiles, i.e., lower maximum plasma concentration (Cmax) and longer time at maximum concentration (Tmax). Compounds 5 and 10, modified with 20 kDa PEG at the N-terminus and eicosanedioic acid at the Lys30 side chain of 1, respectively, showed high Y2R binding affinity and induced significant body weight reduction upon once-daily administration to DIO mice. Compounds 5 and 10, with their relatively low Cmax and long Tmax, partially attenuated emesis in dogs compared with 1. These results indicate that optimization of pharmacokinetic properties of Y2R agonists is an effective strategy to alleviate emesis induced by Y2R agonism.

リンク情報
DOI
https://doi.org/10.1016/j.bmc.2017.12.014
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29279243
ID情報
  • DOI : 10.1016/j.bmc.2017.12.014
  • PubMed ID : 29279243

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