Taisuke Mochida

Identification and removal of unexpected proliferative off-target cells emerging after iPSC-derived pancreatic islet cell implantation.

Hideyuki Hiyoshi, Kensuke Sakuma, Shinya Asano, Stephanie C Napier, Shuhei Konagaya, Taisuke Mochida, Hikaru Ueno, Takeshi Watanabe, Yoshiaki Kassai, Hirokazu Matsumoto …

Proceedings of the National Academy of Sciences of the United States of America, 121(16) e2320883121, Apr 16, 2024

Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC.

Hideyuki Hiyoshi, Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Shinya Asano, Taisuke Mochida, Junji Yamaura, Shuhei Konagaya, Ryo Fujii, Hirokazu Matsumoto, Ryo Ito …

Scientific reports, 12(1) 4740-4740, Mar 18, 2022

Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell-Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice.

Taisuke Mochida, Hikaru Ueno, Noriko Tsubooka-Yamazoe, Hideyuki Hiyoshi, Ryo Ito, Hirokazu Matsumoto, Taro Toyoda

Diabetes, 69(4) 634-646, Apr, 2020 Peer-reviewed

Inhibition of MGAT2 modulates fat-induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high-fat diet.

Taisuke Mochida, Kazumi Take, Toshiyuki Maki, Masanori Nakakariya, Ryutaro Adachi, Kenjiro Sato, Tomoyuki Kitazaki, Shiro Takekawa

FEBS open bio, 10(3) 316-326, Mar, 2020 Peer-reviewed

Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.

Ayumu Niida, Yoko Kanematsu-Yamaki, Tomoko Asakawa, Yoshimasa Ishimura, Hisashi Fujita, Kouta Matsumiya, Naoki Nishizawa, Yusuke Adachi, Taisuke Mochida, Kazue Tsuchimori …

Bioorganic & medicinal chemistry, 26(3) 566-572, Feb 1, 2018 Peer-reviewed

Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.

Yoko Kanematsu-Yamaki, Naoki Nishizawa, Tomoko Kaisho, Hiroaki Nagai, Taisuke Mochida, Tomoko Asakawa, Hiroshi Inooka, Katsuko Dote, Hisashi Fujita, Kouta Matsumiya …

Journal of medicinal chemistry, 60(14) 6089-6097, Jul 27, 2017 Peer-reviewed

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization.

Kazumi Take, Taisuke Mochida, Toshiyuki Maki, Yoshinori Satomi, Megumi Hirayama, Masanori Nakakariya, Nobuyuki Amano, Ryutaro Adachi, Kenjiro Sato, Tomoyuki Kitazaki …

PloS one, 11(3) e0150976, 2016 Peer-reviewed

Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.

Kenjiro Sato, Hiroki Takahagi, Takeshi Yoshikawa, Shinji Morimoto, Takafumi Takai, Kousuke Hidaka, Masahiro Kamaura, Osamu Kubo, Ryutaro Adachi, Tsuyoshi Ishii …

Journal of medicinal chemistry, 58(9) 3892-909, May 14, 2015 Peer-reviewed

The corn protein, zein hydrolysate, administered into the ileum attenuates hyperglycemia via its dual action on glucagon-like peptide-1 secretion and dipeptidyl peptidase-IV activity in rats.

Taisuke Mochida, Tohru Hira, Hiroshi Hara

Endocrinology, 151(7) 3095-104, Jul, 2010 Peer-reviewed

GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats.

Tohru Hira, Taisuke Mochida, Kyoko Miyashita, Hiroshi Hara

American journal of physiology. Gastrointestinal and liver physiology, 297(4) G663-71, Oct, 2009 Peer-reviewed

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