2017年
Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys.
Scientific data
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- 巻
- 4
- 号
- 開始ページ
- 170067
- 終了ページ
- 170067
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/sdata.2017.67
- 出版者・発行元
- Springer Nature
In mammals, the development of pluripotency and specification of primordial germ cells (PGCs) have been studied predominantly using mice as a model organism. However, divergences among mammalian species for such processes have begun to be recognized. Between humans and mice, pre-implantation development appears relatively similar, but the manner and morphology of post-implantation development are significantly different. Nevertheless, the embryogenesis just after implantation in primates, including the specification of PGCs, has been unexplored due to the difficulties in analyzing the embryos at relevant developmental stages. Here, we present a comprehensive single-cell transcriptome dataset of pre- and early post-implantation embryo cells, PGCs and embryonic stem cells (ESCs) of cynomolgus monkeys as a model of higher primates. The identities of each transcriptome were also validated rigorously by other way such as immunofluorescent analysis. The information reported here will serve as a foundation for our understanding of a wide range of processes in the developmental biology of primates, including humans.
- リンク情報
- ID情報
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- DOI : 10.1038/sdata.2017.67
- ORCIDのPut Code : 34978153
- PubMed ID : 28649393
- PubMed Central 記事ID : PMC5477564