論文

査読有り 招待有り 筆頭著者 責任著者 国際誌
2021年5月11日

Non-human primates as a model for human development.

Stem cell reports
  • Tomonori Nakamura
  • ,
  • Kohei Fujiwara
  • ,
  • Mitinori Saitou
  • ,
  • Tomoyuki Tsukiyama

16
5
開始ページ
1093
終了ページ
1103
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.stemcr.2021.03.021

Human development has been studied for over a century, but the molecular mechanisms underlying human embryogenesis remain largely unknown due to technical difficulties and ethical issues. Accordingly, mice have been used as a model for mammalian development and studied extensively to infer human biology based on the conservation of fundamental processes between the two species. As research has progressed, however, species-specific differences in characteristics between rodents and primates have become apparent. Non-human primates (NHPs) have also been used for biomedical research, and are now attracting attention as a model for human development. Here, we summarize primate species from the evolutionary and genomic points of view. Then we review the current issues and progress in gene modification technology for NHPs. Finally, we discuss recent studies on the early embryogenesis of primates and future perspectives.

リンク情報
DOI
https://doi.org/10.1016/j.stemcr.2021.03.021
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33979596
共同研究・競争的資金等の研究課題
霊長類発生学研究の基盤構築
共同研究・競争的資金等の研究課題
臓器形成期までの生体内情報取得と生理的Ex vivo culture法の確立
共同研究・競争的資金等の研究課題
ヒト多能性幹細胞における分化偏向性の解消
ID情報
  • DOI : 10.1016/j.stemcr.2021.03.021
  • PubMed ID : 33979596
  • 共同研究・競争的資金等の研究課題の業績ID : 30748785
  • 共同研究・競争的資金等の研究課題の業績ID : 30748787
  • 共同研究・競争的資金等の研究課題の業績ID : 24592876

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