Takahiro Nobukuni

Profile Information

Affiliation: 講師, 東北大学東北メディカル・メガバンク機構

Degree: 理学博士(東京大学)

J-GLOBAL ID: 201401056101946715
researchmap Member ID: B000241752

Research Areas

Life sciences / Molecular biology /

Papers

Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Yoshie Saito, Keigo Sato, Shinji Jinno, Yoshitaka Nakamura, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Kinuko Ohneda …

Nutrients, 16(1), Dec 31, 2023
Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information.

Hisaaki Kudo, Noriko Ishida, Takahiro Nobukuni, Yuichi Aoki, Sakae Saito, Ichiko Nishijima, Takahiro Terakawa, Masayuki Yamamoto, Naoko Minegishi, Riu Yamashita …

Biopreservation and biobanking, Dec 11, 2023
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project.

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura …

Human genome variation, 8(1) 44-44, Dec 10, 2021
Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines

Noriko Ishida, Yuichi Aoki, Fumiki Katsuoka, Ichiko Nishijima, Takahiro Nobukuni, Hayato Anzawa, Li Bin, Miyuki Tsuda, Kazuki Kumada, Hisaaki Kudo …

Free Radical Biology and Medicine, 161 71-83, Dec, 2020
Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project

Naoko Minegishi, Ichiko Nishijima, Takahiro Nobukuni, Hisaaki Kudo, Noriko Ishida, Takahiro Terakawa, Kazuki Kumada, Riu Yamashita, Fumiki Katsuoka, Soichi Ogishima …

The Tohoku Journal of Experimental Medicine, 248(1) 45-55, 2019 Peer-reviewed
Amino acids activate mTOR Complex 1 via Ca2+/CaM signaling to hVps34

Pawan Gulati, Lawrence D. Gaspers, Stephen G. Dann, Manel Joaquin, Takahiro Nobukuni, Francois Natt, Sara C. Kozma, Andrew P. Thomas, George Thomas

CELL METABOLISM, 7(5) 456-465, May, 2008 Peer-reviewed
Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

Gunnar Johansson, Yonatan Y. Mahller, Margaret H. Collins, Mi-Ok Kim, Takahiro Nobukuni, John Perentesis, Timothy P. Cripe, Heidi A. Lane, Sara C. Kozma, George Thomas …

MOLECULAR CANCER THERAPEUTICS, 7(5) 1237-1245, May, 2008 Peer-reviewed
hvps34, an ancient player, enters a growing game: mTOR Complex1l/S6K1 signaling

Takahiro Nobukuni, Sara C. Kozma, George Thomas

CURRENT OPINION IN CELL BIOLOGY, 19(2) 135-141, Apr, 2007 Peer-reviewed
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase

T Nobukuni, M Joaquin, M Roccio, SG Dann, SY Kim, P Gulati, MP Byfield, JM Backer, F Natt, JL Bos …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(40) 14238-14243, Oct, 2005 Peer-reviewed
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

A Garami, FJT Zwartkruis, T Nobukuni, M Joaquin, M Roccio, H Stocker, SC Kozma, E Hafen, JL Bos, G Thomas

MOLECULAR CELL, 11(6) 1457-1466, Jun, 2003 Peer-reviewed
Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization

S Maeda, T Nobukuni, K Shimo-Onoda, K Hayashi, K Yone, S Komiya, Inoue, I

JOURNAL OF CELLULAR PHYSIOLOGY, 193(1) 73-79, Oct, 2002 Peer-reviewed
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

A Jaeschke, J Hartkamp, M Saitoh, W Roworth, T Nobukuni, A Hodges, J Sampson, G Thomas, R Lamb

JOURNAL OF CELL BIOLOGY, 159(2) 217-224, Oct, 2002 Peer-reviewed
Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer

H Fukuhara, M Kuramochi, T Fukami, K Kasahara, N Furuhata, T Nobukuni, T Maruyama, K Isogai, T Sekiya, T Shuin …

JAPANESE JOURNAL OF CANCER RESEARCH, 93(6) 605-609, Jun, 2002 Peer-reviewed
Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine

K Furushima, K Shimo-Onoda, S Maeda, T Nobukuni, K Ikari, H Koga, S Komiya, T Nakajima, S Harata, Inoue, I

JOURNAL OF BONE AND MINERAL RESEARCH, 17(1) 128-137, Jan, 2002 Peer-reviewed
Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins

H Fukuhara, M Kuramochi, T Nobukuni, T Fukami, M Saino, T Maruyama, S Nomura, T Sekiya, Y Murakami

ONCOGENE, 20(38) 5401-5407, Aug, 2001 Peer-reviewed
Identification of tumor suppressor candidate genes by physical and sequence mapping of the TSLC1 region of human chromosome 11q23

MT Pletcher, T Nobukuni, H Fukuhara, M Kuramochi, T Maruyama, T Sekiya, T Sussan, M Isomura, Y Murakami, RH Reeves

GENE, 273(2) 181-189, Aug, 2001 Peer-reviewed
Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1

S Iwashita, T Itoh, H Takeda, Y Sugimoto, Takahashi, I, T Nobukuni, M Sezaki, T Masui, K Hashimoto

GENE, 268(1-2) 59-66, May, 2001 Peer-reviewed
TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer

M Kuramochi, H Fukuhara, T Nobukuni, T Kanbe, T Maruyama, HP Ghosh, M Pletcher, M Isomura, M Onizuka, T Kitamura …

NATURE GENETICS, 27(4) 427-430, Apr, 2001 Peer-reviewed
Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene

M Kanamori, H Kon, T Nobukuni, S Nomura, K Sugano, S Mashiyama, T Kumabe, T Yoshimoto, M Meuth, T Sekiya …

ONCOGENE, 19(12) 1564-1571, Mar, 2000 Peer-reviewed
Detection of amplification of a chromosomal fragment at 6p21 including the cyclin D3 gene in a glioblastoma cell line by arbitrarily primed polymerase chain reaction

H Kuchiki, M Saino, T Nobukuni, J Yasuda, T Maruyama, T Kayama, Y Murakami, T Sekiya

INTERNATIONAL JOURNAL OF CANCER, 85(1) 113-116, Jan, 2000 Peer-reviewed

Misc.

【ヒト疾患のデータベースとバイオバンク情報をどう使い、どう活かすか?ゲノム医療をどう実現するか?】 (第2章)疾患データベースとバイオバンクプロジェクトの最前線と利用の実践ガイド現代的なバイオバンクの発達とその利用法

信國宇洋

実験医学, 35(17) 2958-2962, Nov, 2017
疾患データベースとバイオバンク【プロジェクトの最前線と利用の実践ガイド】16.現代的なバイオバンクの発達とその利用法

信國宇洋

実験医学, 35(17) 2958‐2962, Nov 1, 2017
疾患研究における一般住民型大規模バイオバンクの試料管理体制の重要性

峯岸直子, 工藤久智, 信國宇洋, 寺川貴裕, 石田典子, 西島維知子, 山下理宇

日本生化学会大会(Web), 89th ROMBUNNO.3P‐330 (WEB ONLY)-330], Sep, 2016
Plasma proteome analysis for a large-scale population-based cohort study

Katoh Yasutake, Koshiba Seizo, Igarashi Kazuhiko, Yamamoto Masayuki, Tanabe Osamu, Ebina Masayuki, Shirota Matsuyuki, Motoike Ikuko, Kinoshita Kengo, Kudo Hisaaki …

Abstracts for Annual Meeting of Japanese Proteomics Society, 2015 62-62, 2015
機能的相補法によるがん抑制遺伝子TSLC1の同定と機能解析

村上善則, 深見武史, 増田万里, 八下田美佳, 丸山智子, 磯貝香奈, 福原浩, 倉持雅己, 信國宇洋

日本癌学会総会記事, 61回 79-79, Oct, 2002
Neurotensin and sortilin/neurotensin receptor-3 promote extra-cellular matrix mineralization during osteoblastic differentiation of mesenchymal stem cells.

S Maeda, T Nobukuni, K Shimo-Onoda, K Hayashi, K Yone, S Komiya, Inoue, I

JOURNAL OF BONE AND MINERAL RESEARCH, 17 S401-S401, Sep, 2002
骨関節疾患の遺伝子解析ソルチリンはヒト間葉系幹細胞の骨芽細胞分化を抑制するリポプロテイン・リパーゼを阻害して石灰化を促進する

前田真吾, 信國宇洋, 下小野田, 一騎, 林協司, 米和徳, 小宮節郎, 井ノ上逸朗

日本整形外科学会雑誌, 76(8) S903-S903, Aug, 2002
Osteogenic differentiation of human mesenchymal stem cell could be regulated by beta-catenin pathway.

S Maeda, K Shimo-Onoda, T Nobukuni, K Hayashi, H Koga, S Matsunaga, K Yone, S Komiya, Inoue, I

JOURNAL OF BONE AND MINERAL RESEARCH, 16 S493-S493, Sep, 2001
Extensive screening of candidate genes for ossification of the posterior longitudinal ligament of the spine.

K Furushima, T Tanaka, S Maeda, N Ikari, T Nobukuni, K Shimo-onoda, T Nakajima, S Komiya, S Harata, Inoue, I

JOURNAL OF BONE AND MINERAL RESEARCH, 16 S248-S248, Sep, 2001
前立腺癌における新規がん抑制遺伝子TSLC1の不活化と腫瘍形成の抑制

福原浩, 倉持雅己, 信國宇洋, 深見武史, 丸山智子, 関谷剛男, 村上善則

日本癌学会総会記事, 60回 107-107, Sep, 2001
新規がん抑制遺伝子TSLC1のプロモーター領域のメチル化による不活化

倉持雅己, 福原浩, 深見武史, 神戸貴雅, 信國宇洋, 丸山智子, 関谷剛男, 村上善則

日本癌学会総会記事, 60回 108-108, Sep, 2001
ヒト間葉系幹細胞の骨芽細胞分化とβ-cateninの機能的関連

前田真吾, 下小野田, 一騎, 信國宇洋, 古賀公明, 林協司, 松永俊二, 米和徳, 小宮節郎, 井ノ上逸朗

日本整形外科学会雑誌, 75(8) S849-S849, Aug, 2001
マイクロアレイによるヒト間葉系幹細胞での骨分化誘導関連遺伝子の包括的発現検討

下小野田, 一騎, 前田真吾, 信國宇洋, 古賀公明, 林協司, 松永俊二, 米和徳, 小宮節郎, 井ノ上逸朗

日本整形外科学会雑誌, 75(8) S849-S849, Aug, 2001
ヒト間葉系幹細胞の骨芽細胞分化におけるβ-cateninの関与

前田真吾, 下小野田, 一騎, 信國宇洋, 古賀公明, 林協司, 松永俊二, 米和徳, 小宮節郎, 井ノ上逸朗

日本骨代謝学会雑誌, 19(2) 20-20, Jul, 2001
PP97 新規肺非小細胞がん抑制遺伝子TSLC1の同定と解析

倉持雅己, 福原浩, 信國宇洋, 神戸貴雅, 鬼塚正孝, 村上善則

日本外科学会雑誌, 102, Mar 10, 2001
新規肺非小細胞がん抑制遺伝子TSLC1の同定と解析

倉持雅己, 福原浩, 信國宇洋, 神戸貴雅, 鬼塚正孝, 村上善則

日本外科学会雑誌, 102(臨増) 248-248, Mar, 2001
前立腺癌における新規がん抑制遺伝子TSLC1の発現低下、並びに腫瘍形成の抑制

福原浩, 倉持雅己, 信國宇洋, 北村唯一, 関谷剛男, 村上善則

日本泌尿器科學會雜誌, 92(2) 367-367, Feb 20, 2001
前立腺癌における新規がん抑制遺伝子TSLC1の発現低下,ならびに腫瘍形成の抑制

福原浩, 倉持雅己, 信國宇洋, 北村唯一, 関谷剛男, 村上善則

日本泌尿器科学会雑誌, 92(2) 367-367, Feb, 2001
Four single-nucleotide polymorphisms in the human BUB1 gene

T Kanbe, T Nobukuni, H Kawasaki, T Sekiya, Y Murakami

JOURNAL OF HUMAN GENETICS, 46(3) 150-151, 2001
新規肺非小細胞がん抑制遺伝子TSLC1の単離と解析

村上善則, 倉持雅己, 福原浩, 信國宇洋, 丸山智子, 大木操, 関谷剛男

日本癌学会総会記事, 59回 222-222, Sep, 2000

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THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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腸内・腫瘍内細菌叢による膠芽腫治療の新機軸

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

金森政之, 山下理宇, 齋藤さかえ, 信國宇洋, 下田由輝

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